Changes in the acid resistance of erythrocytes upon contact with TiC, TiN, Ti-Nb, Ti-Zr and Ti-Ta compositions
Background — There is a high demand for new implant materials in traumatology, orthopedics and dentistry. Biodegradation of titanium alloys leads to undesirable effects that reduce the quality of life in patients with implants. Metal ceramics titanium carbide and titanium nitride, as well as binary...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Limited liability company «Science and Innovations» (Saratov)
2025-06-01
|
| Series: | Russian Open Medical Journal |
| Subjects: | |
| Online Access: | https://romj.org/node/612 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Background — There is a high demand for new implant materials in traumatology, orthopedics and dentistry. Biodegradation of titanium alloys leads to undesirable effects that reduce the quality of life in patients with implants. Metal ceramics titanium carbide and titanium nitride, as well as binary alloys (titanium-niobium, titanium-tantalum and titanium-zirconium) applied to implants by electrospark deposition (ESD), improve their performance, while their biosafety has not been fully confirmed.
Objective — To study the effect of ESD coatings of titanium nitride, titanium carbide, titanium-niobium, titanium-tantalum and titanium-zirconium on the course of acid hemolysis induced by HCl.
Methods — To test biocompatibility, coating samples on Ti6Al4V alloy substrates were incubated with a suspension of erythrocytes. After incubation, the suspension was subjected to a test for HCl-induced hemolysis with photometric recording of hemolysis dynamics parameters and calculation of erythrocyte subpopulation volumes.
Results — HCl-induced hemolysis was more forceful after contact of erythrocytes with uncoated Ti6Al4V alloy, titanium carbide and titanium nitride coatings. The maximum hemolysis rate increased, and the onset and end points of hemolysis shifted. Titanium-niobium, titanium-tantalum and titanium-zirconium coatings were not completely inert, but the demonstrated reactivity did not exceed the parameters of uncoated Ti6Al4V.
Conclusion — Based on the obtained results, a pronounced membranotropic effect of ESD coatings made of titanium carbide and titanium nitride was determined. The effect of coatings made of titanium-niobium, titanium-tantalum and titanium-zirconium alloys is limited and allows them to be considered as hemocompatible and biocompatible coatings. |
|---|---|
| ISSN: | 2304-3415 |