Transplacental sirolimus: a new treatment strategy for life-threatening fetal cardiac rhabdomyomas—a case report

Transplacental sirolimus: a new treatment strategy for life-threatening fetal cardiac rhabdomyomas—a case report

Abstract Large cardiac rhabdomyomas can disturb hemodynamic flow. Tuberous sclerosis complex is the most common cause of cardiac rhabdomyoma in fetuses. Recently, a mammalian target of rapamycin (mTOR) inhibitor effectively treated rhabdomyomas associated with tuberous sclerosis. Here, we report the...

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Bibliographic Details
Main Authors: Kaname Uno, Yoji Nomura, Masahiro Kawaguchi, Anna Ebina, Rina Imanishi, Satoru Kawai, Hiromi Hayakawa
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Orphanet Journal of Rare Diseases
Subjects:
Fetal cardiac rhabdomyoma
Tuberous sclerosis complex
MTOR inhibitor
Sirolimus
Transplacental treatment
Hypo left hemodynamic status
Online Access:https://doi.org/10.1186/s13023-025-03780-7
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