A Comparison of hs-CRP Levels in New Diabetes Groups Diagnosed Based on FPG, 2-hPG, or HbA1c Criteria
Fasting plasma glucose (FPG) and hemoglobin A1c (HbA1c) have been used to diagnose new-onset diabetes mellitus (DM) in order to simplify the diagnostic tests compared with the 2-hour oral glucose tolerance test (OGTT; 2-hPG). We aimed to identify optimal cut-off points of high sensitive C-reactive p...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2016/5827041 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832562625263697920 |
|---|---|
| author | Yildiz Tutuncu Ilhan Satman Selda Celik Nevin Dinccag Kubilay Karsidag Aysegul Telci Sema Genc Halim Issever Jaakko Tuomilehto Beyhan Omer |
| author_facet | Yildiz Tutuncu Ilhan Satman Selda Celik Nevin Dinccag Kubilay Karsidag Aysegul Telci Sema Genc Halim Issever Jaakko Tuomilehto Beyhan Omer |
| author_sort | Yildiz Tutuncu |
| collection | DOAJ |
| description | Fasting plasma glucose (FPG) and hemoglobin A1c (HbA1c) have been used to diagnose new-onset diabetes mellitus (DM) in order to simplify the diagnostic tests compared with the 2-hour oral glucose tolerance test (OGTT; 2-hPG). We aimed to identify optimal cut-off points of high sensitive C-reactive protein (hs-CRP) in new-onset DM people based on FPG, 2-hPG, or HbA1c methods. Data derived from recent population-based survey in Turkey (TURDEP-II). The study included 26,499 adult people (63% women, response rate 85%). The mean serum concentration of hs-CRP in women was higher than in men (p<0.001). The people with new-onset DM based on HbA1c had higher mean hs-CRP level than FPG based and 2-hPG based DM cases. In HbA1c, 2-hPG, and FPG based new-onset DM people, cut-off levels of hs-CRP in women were 2.9, 2.1, and 2.5 mg/L [27.5, 19.7, and 23.5 nmol/L] and corresponding values in men were 2.0, 1.8, and 1.8 mg/L (19.0, 16.9, and 16.9 nmol/L), respectively (sensitivity 60–65% and specificity 54–64%). Our results revealed that hs-CRP may not further strengthen the diagnosis of new-onset DM. Nevertheless, the highest hs-CRP level observed in new-onset DM people diagnosed with HbA1c criterion supports the general assumption that this method might recognize people in more advanced diabetic stage compared with other diagnostic methods. |
| format | Article |
| id | doaj-art-9db51a43e5224ee3a34db8a12d4ee2f3 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-9db51a43e5224ee3a34db8a12d4ee2f32025-02-03T01:22:15ZengWileyJournal of Diabetes Research2314-67452314-67532016-01-01201610.1155/2016/58270415827041A Comparison of hs-CRP Levels in New Diabetes Groups Diagnosed Based on FPG, 2-hPG, or HbA1c CriteriaYildiz Tutuncu0Ilhan Satman1Selda Celik2Nevin Dinccag3Kubilay Karsidag4Aysegul Telci5Sema Genc6Halim Issever7Jaakko Tuomilehto8Beyhan Omer9Division of Endocrinology & Metabolism, Department of Internal Medicine, Istanbul Medical Faculty, Istanbul University, 34093 Istanbul, TurkeyDivision of Endocrinology & Metabolism, Department of Internal Medicine, Istanbul Medical Faculty, Istanbul University, 34093 Istanbul, TurkeyDivision of Endocrinology & Metabolism, Department of Internal Medicine, Istanbul Medical Faculty, Istanbul University, 34093 Istanbul, TurkeyDivision of Endocrinology & Metabolism, Department of Internal Medicine, Istanbul Medical Faculty, Istanbul University, 34093 Istanbul, TurkeyDivision of Endocrinology & Metabolism, Department of Internal Medicine, Istanbul Medical Faculty, Istanbul University, 34093 Istanbul, TurkeyDepartment of Clinical Biochemistry, Istanbul Medical Faculty, Istanbul University, 34093 Istanbul, TurkeyDepartment of Clinical Biochemistry, Istanbul Medical Faculty, Istanbul University, 34093 Istanbul, TurkeyDepartment of Public Health, Istanbul Medical Faculty, Istanbul University, 34093 Istanbul, TurkeyCentre for Vascular Prevention, Danube-University Krems, 3500 Krems, AustriaDepartment of Clinical Biochemistry, Istanbul Medical Faculty, Istanbul University, 34093 Istanbul, TurkeyFasting plasma glucose (FPG) and hemoglobin A1c (HbA1c) have been used to diagnose new-onset diabetes mellitus (DM) in order to simplify the diagnostic tests compared with the 2-hour oral glucose tolerance test (OGTT; 2-hPG). We aimed to identify optimal cut-off points of high sensitive C-reactive protein (hs-CRP) in new-onset DM people based on FPG, 2-hPG, or HbA1c methods. Data derived from recent population-based survey in Turkey (TURDEP-II). The study included 26,499 adult people (63% women, response rate 85%). The mean serum concentration of hs-CRP in women was higher than in men (p<0.001). The people with new-onset DM based on HbA1c had higher mean hs-CRP level than FPG based and 2-hPG based DM cases. In HbA1c, 2-hPG, and FPG based new-onset DM people, cut-off levels of hs-CRP in women were 2.9, 2.1, and 2.5 mg/L [27.5, 19.7, and 23.5 nmol/L] and corresponding values in men were 2.0, 1.8, and 1.8 mg/L (19.0, 16.9, and 16.9 nmol/L), respectively (sensitivity 60–65% and specificity 54–64%). Our results revealed that hs-CRP may not further strengthen the diagnosis of new-onset DM. Nevertheless, the highest hs-CRP level observed in new-onset DM people diagnosed with HbA1c criterion supports the general assumption that this method might recognize people in more advanced diabetic stage compared with other diagnostic methods.http://dx.doi.org/10.1155/2016/5827041 |
| spellingShingle | Yildiz Tutuncu Ilhan Satman Selda Celik Nevin Dinccag Kubilay Karsidag Aysegul Telci Sema Genc Halim Issever Jaakko Tuomilehto Beyhan Omer A Comparison of hs-CRP Levels in New Diabetes Groups Diagnosed Based on FPG, 2-hPG, or HbA1c Criteria Journal of Diabetes Research |
| title | A Comparison of hs-CRP Levels in New Diabetes Groups Diagnosed Based on FPG, 2-hPG, or HbA1c Criteria |
| title_full | A Comparison of hs-CRP Levels in New Diabetes Groups Diagnosed Based on FPG, 2-hPG, or HbA1c Criteria |
| title_fullStr | A Comparison of hs-CRP Levels in New Diabetes Groups Diagnosed Based on FPG, 2-hPG, or HbA1c Criteria |
| title_full_unstemmed | A Comparison of hs-CRP Levels in New Diabetes Groups Diagnosed Based on FPG, 2-hPG, or HbA1c Criteria |
| title_short | A Comparison of hs-CRP Levels in New Diabetes Groups Diagnosed Based on FPG, 2-hPG, or HbA1c Criteria |
| title_sort | comparison of hs crp levels in new diabetes groups diagnosed based on fpg 2 hpg or hba1c criteria |
| url | http://dx.doi.org/10.1155/2016/5827041 |
| work_keys_str_mv | AT yildiztutuncu acomparisonofhscrplevelsinnewdiabetesgroupsdiagnosedbasedonfpg2hpgorhba1ccriteria AT ilhansatman acomparisonofhscrplevelsinnewdiabetesgroupsdiagnosedbasedonfpg2hpgorhba1ccriteria AT seldacelik acomparisonofhscrplevelsinnewdiabetesgroupsdiagnosedbasedonfpg2hpgorhba1ccriteria AT nevindinccag acomparisonofhscrplevelsinnewdiabetesgroupsdiagnosedbasedonfpg2hpgorhba1ccriteria AT kubilaykarsidag acomparisonofhscrplevelsinnewdiabetesgroupsdiagnosedbasedonfpg2hpgorhba1ccriteria AT aysegultelci acomparisonofhscrplevelsinnewdiabetesgroupsdiagnosedbasedonfpg2hpgorhba1ccriteria AT semagenc acomparisonofhscrplevelsinnewdiabetesgroupsdiagnosedbasedonfpg2hpgorhba1ccriteria AT halimissever acomparisonofhscrplevelsinnewdiabetesgroupsdiagnosedbasedonfpg2hpgorhba1ccriteria AT jaakkotuomilehto acomparisonofhscrplevelsinnewdiabetesgroupsdiagnosedbasedonfpg2hpgorhba1ccriteria AT beyhanomer acomparisonofhscrplevelsinnewdiabetesgroupsdiagnosedbasedonfpg2hpgorhba1ccriteria AT yildiztutuncu comparisonofhscrplevelsinnewdiabetesgroupsdiagnosedbasedonfpg2hpgorhba1ccriteria AT ilhansatman comparisonofhscrplevelsinnewdiabetesgroupsdiagnosedbasedonfpg2hpgorhba1ccriteria AT seldacelik comparisonofhscrplevelsinnewdiabetesgroupsdiagnosedbasedonfpg2hpgorhba1ccriteria AT nevindinccag comparisonofhscrplevelsinnewdiabetesgroupsdiagnosedbasedonfpg2hpgorhba1ccriteria AT kubilaykarsidag comparisonofhscrplevelsinnewdiabetesgroupsdiagnosedbasedonfpg2hpgorhba1ccriteria AT aysegultelci comparisonofhscrplevelsinnewdiabetesgroupsdiagnosedbasedonfpg2hpgorhba1ccriteria AT semagenc comparisonofhscrplevelsinnewdiabetesgroupsdiagnosedbasedonfpg2hpgorhba1ccriteria AT halimissever comparisonofhscrplevelsinnewdiabetesgroupsdiagnosedbasedonfpg2hpgorhba1ccriteria AT jaakkotuomilehto comparisonofhscrplevelsinnewdiabetesgroupsdiagnosedbasedonfpg2hpgorhba1ccriteria AT beyhanomer comparisonofhscrplevelsinnewdiabetesgroupsdiagnosedbasedonfpg2hpgorhba1ccriteria |