Cellular Mechanisms of Multiple Myeloma Bone Disease
Multiple myeloma (MM) is a hematologic malignancy of differentiated plasma cells that accumulates and proliferates in the bone marrow. MM patients often develop bone disease that results in severe bone pain, osteolytic lesions, and pathologic fractures. These skeletal complications have not only a n...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2013/289458 |
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| author | Angela Oranger Claudia Carbone Maddalena Izzo Maria Grano |
| author_facet | Angela Oranger Claudia Carbone Maddalena Izzo Maria Grano |
| author_sort | Angela Oranger |
| collection | DOAJ |
| description | Multiple myeloma (MM) is a hematologic malignancy of differentiated plasma cells that accumulates and proliferates in the bone marrow. MM patients often develop bone disease that results in severe bone pain, osteolytic lesions, and pathologic fractures. These skeletal complications have not only a negative impact on quality of life but also a possible effect in overall survival. MM osteolytic bone lesions arise from the altered bone remodeling due to both increased osteoclast activation and decreased osteoblast differentiation. A dysregulated production of numerous cytokines that can contribute to the uncoupling of bone cell activity is well documented in the bone marrow microenvironment of MM patients. These molecules are produced not only by malignant plasma cells, that directly contribute to MM bone disease, but also by bone, immune, and stromal cells interacting with each other in the bone microenvironment. This review focuses on the current knowledge of MM bone disease biology, with particular regard on the role of bone and immune cells in producing cytokines critical for malignant plasma cell proliferation as well as in osteolysis development. Therefore, the understanding of MM pathogenesis could be useful to the discovery of novel agents that will be able to both restore bone remodelling and reduce tumor burden. |
| format | Article |
| id | doaj-art-9db0952e17a047579bf95f60cbc428c3 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-9db0952e17a047579bf95f60cbc428c32025-02-03T05:54:14ZengWileyClinical and Developmental Immunology1740-25221740-25302013-01-01201310.1155/2013/289458289458Cellular Mechanisms of Multiple Myeloma Bone DiseaseAngela Oranger0Claudia Carbone1Maddalena Izzo2Maria Grano3Department of Basic Medical Sciences, Neurosciences and Sense Organs, Section of Human Anatomy and Histology, University of Bari, Piazza Giulio Cesare 11, 70124 Bari, ItalyDepartment of Basic Medical Sciences, Neurosciences and Sense Organs, Section of Human Anatomy and Histology, University of Bari, Piazza Giulio Cesare 11, 70124 Bari, ItalyDepartment of Basic Medical Sciences, Neurosciences and Sense Organs, Section of Human Anatomy and Histology, University of Bari, Piazza Giulio Cesare 11, 70124 Bari, ItalyDepartment of Basic Medical Sciences, Neurosciences and Sense Organs, Section of Human Anatomy and Histology, University of Bari, Piazza Giulio Cesare 11, 70124 Bari, ItalyMultiple myeloma (MM) is a hematologic malignancy of differentiated plasma cells that accumulates and proliferates in the bone marrow. MM patients often develop bone disease that results in severe bone pain, osteolytic lesions, and pathologic fractures. These skeletal complications have not only a negative impact on quality of life but also a possible effect in overall survival. MM osteolytic bone lesions arise from the altered bone remodeling due to both increased osteoclast activation and decreased osteoblast differentiation. A dysregulated production of numerous cytokines that can contribute to the uncoupling of bone cell activity is well documented in the bone marrow microenvironment of MM patients. These molecules are produced not only by malignant plasma cells, that directly contribute to MM bone disease, but also by bone, immune, and stromal cells interacting with each other in the bone microenvironment. This review focuses on the current knowledge of MM bone disease biology, with particular regard on the role of bone and immune cells in producing cytokines critical for malignant plasma cell proliferation as well as in osteolysis development. Therefore, the understanding of MM pathogenesis could be useful to the discovery of novel agents that will be able to both restore bone remodelling and reduce tumor burden.http://dx.doi.org/10.1155/2013/289458 |
| spellingShingle | Angela Oranger Claudia Carbone Maddalena Izzo Maria Grano Cellular Mechanisms of Multiple Myeloma Bone Disease Clinical and Developmental Immunology |
| title | Cellular Mechanisms of Multiple Myeloma Bone Disease |
| title_full | Cellular Mechanisms of Multiple Myeloma Bone Disease |
| title_fullStr | Cellular Mechanisms of Multiple Myeloma Bone Disease |
| title_full_unstemmed | Cellular Mechanisms of Multiple Myeloma Bone Disease |
| title_short | Cellular Mechanisms of Multiple Myeloma Bone Disease |
| title_sort | cellular mechanisms of multiple myeloma bone disease |
| url | http://dx.doi.org/10.1155/2013/289458 |
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