Transcriptomic Profiling of Human Placental Trophoblasts in Response to Infection with Enterococcus faecalis
Increasing evidence suggests that Enterococcus faecalis strains can pass through placental barriers and cause adverse outcomes during pregnancy. However, the underlying molecular mechanism of the interaction between E. faecalis and the host placental barrier has yet to be fully elucidated. In this s...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Food Quality |
| Online Access: | http://dx.doi.org/10.1155/2018/5607641 |
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| _version_ | 1832554917162647552 |
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| author | Qianglai Tan Feng Xu Hengyi Xu Liang Qiu Xueying Tao Hua Wei |
| author_facet | Qianglai Tan Feng Xu Hengyi Xu Liang Qiu Xueying Tao Hua Wei |
| author_sort | Qianglai Tan |
| collection | DOAJ |
| description | Increasing evidence suggests that Enterococcus faecalis strains can pass through placental barriers and cause adverse outcomes during pregnancy. However, the underlying molecular mechanism of the interaction between E. faecalis and the host placental barrier has yet to be fully elucidated. In this study, we have used DNA microarray analysis to investigate the response of human placental trophoblast-like BeWo cells to infection with E. faecalis OG1RF. These results indicate that a total of 2191 genes in BeWo cells are differentially expressed in the presence of E. faecalis OG1RF, with 1357 genes being upregulated and 834 genes being downregulated. These differentially expressed genes (DEGs) are involved in apoptosis, stress and stimulus response, placental and embryonic development, immune response, and cell adhesion. Therefore, these results provide information on the molecular mechanisms that E. faecalis invasion can trigger to cause adverse pregnancy outcomes. |
| format | Article |
| id | doaj-art-9d8d1c6557cb48b8b460523b84a24b5d |
| institution | Kabale University |
| issn | 0146-9428 1745-4557 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Food Quality |
| spelling | doaj-art-9d8d1c6557cb48b8b460523b84a24b5d2025-02-03T05:50:13ZengWileyJournal of Food Quality0146-94281745-45572018-01-01201810.1155/2018/56076415607641Transcriptomic Profiling of Human Placental Trophoblasts in Response to Infection with Enterococcus faecalisQianglai Tan0Feng Xu1Hengyi Xu2Liang Qiu3Xueying Tao4Hua Wei5Institute of Nutrition and Food Safety, Xiamen Medical College, Xiamen, Fujian 361023, ChinaState Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, Jiangxi 330047, ChinaState Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, Jiangxi 330047, ChinaState Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, Jiangxi 330047, ChinaState Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, Jiangxi 330047, ChinaState Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, Jiangxi 330047, ChinaIncreasing evidence suggests that Enterococcus faecalis strains can pass through placental barriers and cause adverse outcomes during pregnancy. However, the underlying molecular mechanism of the interaction between E. faecalis and the host placental barrier has yet to be fully elucidated. In this study, we have used DNA microarray analysis to investigate the response of human placental trophoblast-like BeWo cells to infection with E. faecalis OG1RF. These results indicate that a total of 2191 genes in BeWo cells are differentially expressed in the presence of E. faecalis OG1RF, with 1357 genes being upregulated and 834 genes being downregulated. These differentially expressed genes (DEGs) are involved in apoptosis, stress and stimulus response, placental and embryonic development, immune response, and cell adhesion. Therefore, these results provide information on the molecular mechanisms that E. faecalis invasion can trigger to cause adverse pregnancy outcomes.http://dx.doi.org/10.1155/2018/5607641 |
| spellingShingle | Qianglai Tan Feng Xu Hengyi Xu Liang Qiu Xueying Tao Hua Wei Transcriptomic Profiling of Human Placental Trophoblasts in Response to Infection with Enterococcus faecalis Journal of Food Quality |
| title | Transcriptomic Profiling of Human Placental Trophoblasts in Response to Infection with Enterococcus faecalis |
| title_full | Transcriptomic Profiling of Human Placental Trophoblasts in Response to Infection with Enterococcus faecalis |
| title_fullStr | Transcriptomic Profiling of Human Placental Trophoblasts in Response to Infection with Enterococcus faecalis |
| title_full_unstemmed | Transcriptomic Profiling of Human Placental Trophoblasts in Response to Infection with Enterococcus faecalis |
| title_short | Transcriptomic Profiling of Human Placental Trophoblasts in Response to Infection with Enterococcus faecalis |
| title_sort | transcriptomic profiling of human placental trophoblasts in response to infection with enterococcus faecalis |
| url | http://dx.doi.org/10.1155/2018/5607641 |
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