Associations of Pretransplant Patient-Reported Outcomes Measurement Information System Physical Function Score With Kidney Transplant Outcomes
Simple and validated physical function measures are needed for kidney transplant candidates because pretransplant low physical function is a common and potentially modifiable risk factor. This single-center retrospective study investigated the associations between pretransplant physical function ass...
Saved in:
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-01-01
|
| Series: | Transplant International |
| Subjects: | |
| Online Access: | https://www.frontierspartnerships.org/articles/10.3389/ti.2025.13884/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832583179481907200 |
|---|---|
| author | Junji Yamauchi Amy M. Cizik Katalin Fornadi Dominik Thomas Divya Raghavan Duha Jweehan Suayp Oygen Silviana Marineci Michelle Buff Motaz Selim Michael Zimmerman Istvan Mucsi Istvan Mucsi Miklos Z. Molnar |
| author_facet | Junji Yamauchi Amy M. Cizik Katalin Fornadi Dominik Thomas Divya Raghavan Duha Jweehan Suayp Oygen Silviana Marineci Michelle Buff Motaz Selim Michael Zimmerman Istvan Mucsi Istvan Mucsi Miklos Z. Molnar |
| author_sort | Junji Yamauchi |
| collection | DOAJ |
| description | Simple and validated physical function measures are needed for kidney transplant candidates because pretransplant low physical function is a common and potentially modifiable risk factor. This single-center retrospective study investigated the associations between pretransplant physical function assessed by the Patient-Reported Outcomes Measurement Information System® Physical Function (PROMIS-PF) computer adaptive testing and early posttransplant outcomes. We analyzed 154 adult kidney-alone transplant recipients. The median pretransplant PROMIS-PF score was 43 (interquartile range, 39–47). Patient characteristics were not significantly different across the score category (normal, score ≥45; mild, score of 40–45; and moderate/severe, score <40). The PROMIS-PF score was not associated with length of transplant hospital stay, delayed graft function, 6-month and 12-month graft function, or 12-month patient and graft survival. However, a lower PROMIS-PF score was significantly associated with a higher risk of emergency room visits [adjusted odds ratios compared to normal: mild, 1.68 (95% confidence interval, 0.76–3.83); moderate/severe, 3.23 (1.34–7.79)] and rehospitalization [adjusted odds ratios: mild, 2.61 (1.16–5.90); moderate/severe, 2.53 (1.07–6.00)] within 1 month posttransplant. Results suggest that PROMIS-PF is a practical tool for assessing physical function in kidney transplant candidates. Larger studies are needed to confirm the utility of PROMIS-PF to identify transplant candidates who would benefit from pretransplant prehabilitation. |
| format | Article |
| id | doaj-art-9d700ee7e87847c6a061f6a9eebfe3bd |
| institution | Kabale University |
| issn | 1432-2277 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Transplant International |
| spelling | doaj-art-9d700ee7e87847c6a061f6a9eebfe3bd2025-01-29T04:11:10ZengFrontiers Media S.A.Transplant International1432-22772025-01-013810.3389/ti.2025.1388413884Associations of Pretransplant Patient-Reported Outcomes Measurement Information System Physical Function Score With Kidney Transplant OutcomesJunji Yamauchi0Amy M. Cizik1Katalin Fornadi2Dominik Thomas3Divya Raghavan4Duha Jweehan5Suayp Oygen6Silviana Marineci7Michelle Buff8Motaz Selim9Michael Zimmerman10Istvan Mucsi11Istvan Mucsi12Miklos Z. Molnar13Department of Internal Medicine, Division of Nephrology and Hypertension, Spencer Fox Eccles School of Medicine at the University of Utah, Salt Lake City, UT, United StatesDepartment of Orthopedics, Spencer Fox Eccles School of Medicine at the University of Utah, Salt Lake City, UT, United StatesDepartment of Surgery, Division of Transplantation and Advanced Hepatobiliary Surgery, Spencer Fox Eccles School of Medicine at the University of Utah, Salt Lake City, UT, United StatesDepartment of Internal Medicine, Division of Nephrology and Hypertension, Spencer Fox Eccles School of Medicine at the University of Utah, Salt Lake City, UT, United StatesDepartment of Internal Medicine, Division of Nephrology and Hypertension, Spencer Fox Eccles School of Medicine at the University of Utah, Salt Lake City, UT, United StatesDepartment of Internal Medicine, Division of Nephrology and Hypertension, Spencer Fox Eccles School of Medicine at the University of Utah, Salt Lake City, UT, United StatesDepartment of Internal Medicine, Division of Nephrology and Hypertension, Spencer Fox Eccles School of Medicine at the University of Utah, Salt Lake City, UT, United StatesDepartment of Internal Medicine, Division of Nephrology and Hypertension, Spencer Fox Eccles School of Medicine at the University of Utah, Salt Lake City, UT, United StatesDepartment of Surgery, Division of Transplantation and Advanced Hepatobiliary Surgery, Spencer Fox Eccles School of Medicine at the University of Utah, Salt Lake City, UT, United StatesDepartment of Surgery, Division of Transplantation and Advanced Hepatobiliary Surgery, Spencer Fox Eccles School of Medicine at the University of Utah, Salt Lake City, UT, United StatesDepartment of Surgery, Division of Transplantation and Advanced Hepatobiliary Surgery, Spencer Fox Eccles School of Medicine at the University of Utah, Salt Lake City, UT, United StatesTemerty Faculty of Medicine, University of Toronto, Toronto, ON, CanadaAjmera Transplant Centre, University Health Network, Toronto, ON, CanadaDepartment of Internal Medicine, Division of Nephrology and Hypertension, Spencer Fox Eccles School of Medicine at the University of Utah, Salt Lake City, UT, United StatesSimple and validated physical function measures are needed for kidney transplant candidates because pretransplant low physical function is a common and potentially modifiable risk factor. This single-center retrospective study investigated the associations between pretransplant physical function assessed by the Patient-Reported Outcomes Measurement Information System® Physical Function (PROMIS-PF) computer adaptive testing and early posttransplant outcomes. We analyzed 154 adult kidney-alone transplant recipients. The median pretransplant PROMIS-PF score was 43 (interquartile range, 39–47). Patient characteristics were not significantly different across the score category (normal, score ≥45; mild, score of 40–45; and moderate/severe, score <40). The PROMIS-PF score was not associated with length of transplant hospital stay, delayed graft function, 6-month and 12-month graft function, or 12-month patient and graft survival. However, a lower PROMIS-PF score was significantly associated with a higher risk of emergency room visits [adjusted odds ratios compared to normal: mild, 1.68 (95% confidence interval, 0.76–3.83); moderate/severe, 3.23 (1.34–7.79)] and rehospitalization [adjusted odds ratios: mild, 2.61 (1.16–5.90); moderate/severe, 2.53 (1.07–6.00)] within 1 month posttransplant. Results suggest that PROMIS-PF is a practical tool for assessing physical function in kidney transplant candidates. Larger studies are needed to confirm the utility of PROMIS-PF to identify transplant candidates who would benefit from pretransplant prehabilitation.https://www.frontierspartnerships.org/articles/10.3389/ti.2025.13884/fullkidney transplantationtransplant outcomesPROMIS®Patient-Reported Outcomes Measurement Information System®physical function |
| spellingShingle | Junji Yamauchi Amy M. Cizik Katalin Fornadi Dominik Thomas Divya Raghavan Duha Jweehan Suayp Oygen Silviana Marineci Michelle Buff Motaz Selim Michael Zimmerman Istvan Mucsi Istvan Mucsi Miklos Z. Molnar Associations of Pretransplant Patient-Reported Outcomes Measurement Information System Physical Function Score With Kidney Transplant Outcomes Transplant International kidney transplantation transplant outcomes PROMIS® Patient-Reported Outcomes Measurement Information System® physical function |
| title | Associations of Pretransplant Patient-Reported Outcomes Measurement Information System Physical Function Score With Kidney Transplant Outcomes |
| title_full | Associations of Pretransplant Patient-Reported Outcomes Measurement Information System Physical Function Score With Kidney Transplant Outcomes |
| title_fullStr | Associations of Pretransplant Patient-Reported Outcomes Measurement Information System Physical Function Score With Kidney Transplant Outcomes |
| title_full_unstemmed | Associations of Pretransplant Patient-Reported Outcomes Measurement Information System Physical Function Score With Kidney Transplant Outcomes |
| title_short | Associations of Pretransplant Patient-Reported Outcomes Measurement Information System Physical Function Score With Kidney Transplant Outcomes |
| title_sort | associations of pretransplant patient reported outcomes measurement information system physical function score with kidney transplant outcomes |
| topic | kidney transplantation transplant outcomes PROMIS® Patient-Reported Outcomes Measurement Information System® physical function |
| url | https://www.frontierspartnerships.org/articles/10.3389/ti.2025.13884/full |
| work_keys_str_mv | AT junjiyamauchi associationsofpretransplantpatientreportedoutcomesmeasurementinformationsystemphysicalfunctionscorewithkidneytransplantoutcomes AT amymcizik associationsofpretransplantpatientreportedoutcomesmeasurementinformationsystemphysicalfunctionscorewithkidneytransplantoutcomes AT katalinfornadi associationsofpretransplantpatientreportedoutcomesmeasurementinformationsystemphysicalfunctionscorewithkidneytransplantoutcomes AT dominikthomas associationsofpretransplantpatientreportedoutcomesmeasurementinformationsystemphysicalfunctionscorewithkidneytransplantoutcomes AT divyaraghavan associationsofpretransplantpatientreportedoutcomesmeasurementinformationsystemphysicalfunctionscorewithkidneytransplantoutcomes AT duhajweehan associationsofpretransplantpatientreportedoutcomesmeasurementinformationsystemphysicalfunctionscorewithkidneytransplantoutcomes AT suaypoygen associationsofpretransplantpatientreportedoutcomesmeasurementinformationsystemphysicalfunctionscorewithkidneytransplantoutcomes AT silvianamarineci associationsofpretransplantpatientreportedoutcomesmeasurementinformationsystemphysicalfunctionscorewithkidneytransplantoutcomes AT michellebuff associationsofpretransplantpatientreportedoutcomesmeasurementinformationsystemphysicalfunctionscorewithkidneytransplantoutcomes AT motazselim associationsofpretransplantpatientreportedoutcomesmeasurementinformationsystemphysicalfunctionscorewithkidneytransplantoutcomes AT michaelzimmerman associationsofpretransplantpatientreportedoutcomesmeasurementinformationsystemphysicalfunctionscorewithkidneytransplantoutcomes AT istvanmucsi associationsofpretransplantpatientreportedoutcomesmeasurementinformationsystemphysicalfunctionscorewithkidneytransplantoutcomes AT istvanmucsi associationsofpretransplantpatientreportedoutcomesmeasurementinformationsystemphysicalfunctionscorewithkidneytransplantoutcomes AT mikloszmolnar associationsofpretransplantpatientreportedoutcomesmeasurementinformationsystemphysicalfunctionscorewithkidneytransplantoutcomes |