A case of accidental vincristine overdose and effective use of therapeutic plasma exchange in its management
Vincristine is a common drug used in hematological malignancy with a maximum per dose limited to 2 mg mainly to limit neurotoxicity. Vincristine overdose and wrong route of administration, though has been reported in world literature, but its appropriate management is still undefined. We report a ca...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Thieme Medical and Scientific Publishers Pvt. Ltd.
2020-01-01
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| Series: | Indian Journal of Medical and Paediatric Oncology |
| Subjects: | |
| Online Access: | http://www.ijmpo.org/article.asp?issn=0971-5851;year=2020;volume=41;issue=5;spage=770;epage=772;aulast=Goyal |
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| Summary: | Vincristine is a common drug used in hematological malignancy with a maximum per dose limited to 2 mg mainly to limit neurotoxicity. Vincristine overdose and wrong route of administration, though has been reported in world literature, but its appropriate management is still undefined. We report a case of Hodgkin lymphoma being treated with adriamycin, bleomycin, vinblastine and dacarbazine protocol, where vincristine was accidently administrated instead of vinblastine due to its “look-alike, sound-alike” nature. The patient developed severe toxicity due to the same, which was effectively managed by therapeutic plasma exchange. |
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| ISSN: | 0971-5851 0975-2129 |