Ubiquitination of Neurotransmitter Receptors and Postsynaptic Scaffolding Proteins
The human brain is made up of an extensive network of neurons that communicate by forming specialized connections called synapses. The amount, location, and dynamic turnover of synaptic proteins, including neurotransmitter receptors and synaptic scaffolding molecules, are under complex regulation an...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2013/432057 |
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| author | Amy W. Lin Heng-Ye Man |
| author_facet | Amy W. Lin Heng-Ye Man |
| author_sort | Amy W. Lin |
| collection | DOAJ |
| description | The human brain is made up of an extensive network of neurons that communicate by forming specialized connections called synapses. The amount, location, and dynamic turnover of synaptic proteins, including neurotransmitter receptors and synaptic scaffolding molecules, are under complex regulation and play a crucial role in synaptic connectivity and plasticity, as well as in higher brain functions. An increasing number of studies have established ubiquitination and proteasome-mediated degradation as universal mechanisms in the control of synaptic protein homeostasis. In this paper, we focus on the role of the ubiquitin-proteasome system (UPS) in the turnover of major neurotransmitter receptors, including glutamatergic and nonglutamatergic receptors, as well as postsynaptic receptor-interacting proteins. |
| format | Article |
| id | doaj-art-9d5df85e5fa64eb6ad2afea4d818b880 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-9d5df85e5fa64eb6ad2afea4d818b8802025-02-03T01:22:10ZengWileyNeural Plasticity2090-59041687-54432013-01-01201310.1155/2013/432057432057Ubiquitination of Neurotransmitter Receptors and Postsynaptic Scaffolding ProteinsAmy W. Lin0Heng-Ye Man1Department of Biology, Boston University, 5 Cummington Mall, Boston, MA 02215, USADepartment of Biology, Boston University, 5 Cummington Mall, Boston, MA 02215, USAThe human brain is made up of an extensive network of neurons that communicate by forming specialized connections called synapses. The amount, location, and dynamic turnover of synaptic proteins, including neurotransmitter receptors and synaptic scaffolding molecules, are under complex regulation and play a crucial role in synaptic connectivity and plasticity, as well as in higher brain functions. An increasing number of studies have established ubiquitination and proteasome-mediated degradation as universal mechanisms in the control of synaptic protein homeostasis. In this paper, we focus on the role of the ubiquitin-proteasome system (UPS) in the turnover of major neurotransmitter receptors, including glutamatergic and nonglutamatergic receptors, as well as postsynaptic receptor-interacting proteins.http://dx.doi.org/10.1155/2013/432057 |
| spellingShingle | Amy W. Lin Heng-Ye Man Ubiquitination of Neurotransmitter Receptors and Postsynaptic Scaffolding Proteins Neural Plasticity |
| title | Ubiquitination of Neurotransmitter Receptors and Postsynaptic Scaffolding Proteins |
| title_full | Ubiquitination of Neurotransmitter Receptors and Postsynaptic Scaffolding Proteins |
| title_fullStr | Ubiquitination of Neurotransmitter Receptors and Postsynaptic Scaffolding Proteins |
| title_full_unstemmed | Ubiquitination of Neurotransmitter Receptors and Postsynaptic Scaffolding Proteins |
| title_short | Ubiquitination of Neurotransmitter Receptors and Postsynaptic Scaffolding Proteins |
| title_sort | ubiquitination of neurotransmitter receptors and postsynaptic scaffolding proteins |
| url | http://dx.doi.org/10.1155/2013/432057 |
| work_keys_str_mv | AT amywlin ubiquitinationofneurotransmitterreceptorsandpostsynapticscaffoldingproteins AT hengyeman ubiquitinationofneurotransmitterreceptorsandpostsynapticscaffoldingproteins |