IgG4-Related Orbital Disease: An Analysis of Patient Profiles, Clinical Presentation, And Histopathological Features
Objective: To study various presentations of patients with a histopathologically confirmed diagnosis of IgG4 disease. Methods: This study is a retrospective review of medical records from the IgG4-RD registry at the Al-Shifa Trust Eye Hospital. Nine patients with orbital manifestations were ident...
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| Format: | Article |
| Language: | English |
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Rawalpindi Medical University
2024-06-01
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| Series: | Journal of Rawalpindi Medical College |
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| Online Access: | https://www.journalrmc.com/index.php/JRMC/article/view/2501 |
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| author | Fariha Taimur Amna Manzoor Muhammad Saad Faizan Tahir Sumeya Khan Aashar Khalid |
| author_facet | Fariha Taimur Amna Manzoor Muhammad Saad Faizan Tahir Sumeya Khan Aashar Khalid |
| author_sort | Fariha Taimur |
| collection | DOAJ |
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Objective: To study various presentations of patients with a histopathologically confirmed diagnosis of IgG4 disease.
Methods: This study is a retrospective review of medical records from the IgG4-RD registry at the Al-Shifa Trust Eye Hospital. Nine patients with orbital manifestations were identified. All had histopathologically confirmed diagnoses of IgG4-RD. Data obtained from the medical records included patient demographic information (name, age, gender), brief patient history, clinical presentation, histopathology reports, and diagnoses.
Results: Most patients presented with proptosis and swelling in various parts of the orbital area. Some patients also presented with pain and diplopia. The most common orbital structures involved were the lacrimal gland and the extraocular muscles, with some patients also having soft tissue involvement. 4(44%) patients had bilateral orbital involvement, while the remaining 5(55%) had unilateral disease.
Conclusion: Ophthalmic involvement is a feature of IgG4-RD and has significant implications regarding the diagnosis, prognosis, and treatment of patients with IgG4 disease.
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| format | Article |
| id | doaj-art-9d26c1b9755d4c56a18d5940235459bf |
| institution | Kabale University |
| issn | 1683-3562 1683-3570 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | Rawalpindi Medical University |
| record_format | Article |
| series | Journal of Rawalpindi Medical College |
| spelling | doaj-art-9d26c1b9755d4c56a18d5940235459bf2025-02-06T08:36:00ZengRawalpindi Medical UniversityJournal of Rawalpindi Medical College1683-35621683-35702024-06-0128210.37939/jrmc.v28i2.2501IgG4-Related Orbital Disease: An Analysis of Patient Profiles, Clinical Presentation, And Histopathological FeaturesFariha TaimurAmna ManzoorMuhammad SaadFaizan TahirSumeya KhanAashar Khalid Objective: To study various presentations of patients with a histopathologically confirmed diagnosis of IgG4 disease. Methods: This study is a retrospective review of medical records from the IgG4-RD registry at the Al-Shifa Trust Eye Hospital. Nine patients with orbital manifestations were identified. All had histopathologically confirmed diagnoses of IgG4-RD. Data obtained from the medical records included patient demographic information (name, age, gender), brief patient history, clinical presentation, histopathology reports, and diagnoses. Results: Most patients presented with proptosis and swelling in various parts of the orbital area. Some patients also presented with pain and diplopia. The most common orbital structures involved were the lacrimal gland and the extraocular muscles, with some patients also having soft tissue involvement. 4(44%) patients had bilateral orbital involvement, while the remaining 5(55%) had unilateral disease. Conclusion: Ophthalmic involvement is a feature of IgG4-RD and has significant implications regarding the diagnosis, prognosis, and treatment of patients with IgG4 disease. https://www.journalrmc.com/index.php/JRMC/article/view/2501Ig4 diseasehistopathology |
| spellingShingle | Fariha Taimur Amna Manzoor Muhammad Saad Faizan Tahir Sumeya Khan Aashar Khalid IgG4-Related Orbital Disease: An Analysis of Patient Profiles, Clinical Presentation, And Histopathological Features Journal of Rawalpindi Medical College Ig4 disease histopathology |
| title | IgG4-Related Orbital Disease: An Analysis of Patient Profiles, Clinical Presentation, And Histopathological Features |
| title_full | IgG4-Related Orbital Disease: An Analysis of Patient Profiles, Clinical Presentation, And Histopathological Features |
| title_fullStr | IgG4-Related Orbital Disease: An Analysis of Patient Profiles, Clinical Presentation, And Histopathological Features |
| title_full_unstemmed | IgG4-Related Orbital Disease: An Analysis of Patient Profiles, Clinical Presentation, And Histopathological Features |
| title_short | IgG4-Related Orbital Disease: An Analysis of Patient Profiles, Clinical Presentation, And Histopathological Features |
| title_sort | igg4 related orbital disease an analysis of patient profiles clinical presentation and histopathological features |
| topic | Ig4 disease histopathology |
| url | https://www.journalrmc.com/index.php/JRMC/article/view/2501 |
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