Role of MMP-2 (-1306 C/T) Polymorphism in Pituitary Adenoma
Purpose. To determine if the frequency of the genotype of MMP-2 (-1306 C/T) Rs243865 has an influence on the development of pituitary adenoma (PA). Methods. The study enrolled n=84 patients with PA and a random sample of the population n=318 (reference group). The genotyping test of MMP-2 (-1306 C/T...
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| Format: | Article |
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Wiley
2016-01-01
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| Series: | Scientifica |
| Online Access: | http://dx.doi.org/10.1155/2016/2839697 |
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| author | Brigita Glebauskiene Rasa Liutkeviciene Alvita Vilkeviciute Loresa Kriauciuniene Giedrimantas Bernotas Arimantas Tamasauskas Dalia Zaliuniene |
| author_facet | Brigita Glebauskiene Rasa Liutkeviciene Alvita Vilkeviciute Loresa Kriauciuniene Giedrimantas Bernotas Arimantas Tamasauskas Dalia Zaliuniene |
| author_sort | Brigita Glebauskiene |
| collection | DOAJ |
| description | Purpose. To determine if the frequency of the genotype of MMP-2 (-1306 C/T) Rs243865 has an influence on the development of pituitary adenoma (PA). Methods. The study enrolled n=84 patients with PA and a random sample of the population n=318 (reference group). The genotyping test of MMP-2 (-1306 C/T) was carried out using the real-time polymerase chain reaction method. Results. Analysis of MMP-2 (-1306 C/T) gene polymorphism has not revealed any differences in the genotype (C/C, C/T, and T/T) distribution between the PA patients and the reference group (as follows: 50%, 44%, and 6% versus 59.75%, 33.96%, and 6.29%). MMP-2 (-1306) C/C genotype was rarely observed in noninvasive PA compared to healthy controls: 35.1% versus 59.75%; p=0.0049, as well C/C genotype being more frequently detected in nonrecurrence PA compared to healthy controls: 46.5% versus 59.75%; p=0.0468. MMP-2 (-1306) C/T genotype was more frequently present in PA females compared to healthy controls females: 49.1% versus 33.66%; p=0.041. Conclusion. Patients with noninvasive and nonrecurrence pituitary adenoma were the carriers of the C/C genotype significantly more frequently than their control counterparts and the C/T genotype in females was more frequent. |
| format | Article |
| id | doaj-art-9d241dbb43bf4262a85278dc8e5d990a |
| institution | Kabale University |
| issn | 2090-908X |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Scientifica |
| spelling | doaj-art-9d241dbb43bf4262a85278dc8e5d990a2025-02-03T01:12:07ZengWileyScientifica2090-908X2016-01-01201610.1155/2016/28396972839697Role of MMP-2 (-1306 C/T) Polymorphism in Pituitary AdenomaBrigita Glebauskiene0Rasa Liutkeviciene1Alvita Vilkeviciute2Loresa Kriauciuniene3Giedrimantas Bernotas4Arimantas Tamasauskas5Dalia Zaliuniene6Medical Academy, Department of Ophthalmology, Lithuanian University of Health Sciences, Eiveniu 2, 50009 Kaunas, LithuaniaMedical Academy, Department of Ophthalmology, Lithuanian University of Health Sciences, Eiveniu 2, 50009 Kaunas, LithuaniaNeuroscience Institute, Medical Academy, Lithuanian University of Health Sciences, Eiveniu 2, 50009 Kaunas, LithuaniaMedical Academy, Department of Ophthalmology, Lithuanian University of Health Sciences, Eiveniu 2, 50009 Kaunas, LithuaniaNeuroscience Institute, Medical Academy, Lithuanian University of Health Sciences, Eiveniu 2, 50009 Kaunas, LithuaniaNeuroscience Institute, Medical Academy, Lithuanian University of Health Sciences, Eiveniu 2, 50009 Kaunas, LithuaniaMedical Academy, Department of Ophthalmology, Lithuanian University of Health Sciences, Eiveniu 2, 50009 Kaunas, LithuaniaPurpose. To determine if the frequency of the genotype of MMP-2 (-1306 C/T) Rs243865 has an influence on the development of pituitary adenoma (PA). Methods. The study enrolled n=84 patients with PA and a random sample of the population n=318 (reference group). The genotyping test of MMP-2 (-1306 C/T) was carried out using the real-time polymerase chain reaction method. Results. Analysis of MMP-2 (-1306 C/T) gene polymorphism has not revealed any differences in the genotype (C/C, C/T, and T/T) distribution between the PA patients and the reference group (as follows: 50%, 44%, and 6% versus 59.75%, 33.96%, and 6.29%). MMP-2 (-1306) C/C genotype was rarely observed in noninvasive PA compared to healthy controls: 35.1% versus 59.75%; p=0.0049, as well C/C genotype being more frequently detected in nonrecurrence PA compared to healthy controls: 46.5% versus 59.75%; p=0.0468. MMP-2 (-1306) C/T genotype was more frequently present in PA females compared to healthy controls females: 49.1% versus 33.66%; p=0.041. Conclusion. Patients with noninvasive and nonrecurrence pituitary adenoma were the carriers of the C/C genotype significantly more frequently than their control counterparts and the C/T genotype in females was more frequent.http://dx.doi.org/10.1155/2016/2839697 |
| spellingShingle | Brigita Glebauskiene Rasa Liutkeviciene Alvita Vilkeviciute Loresa Kriauciuniene Giedrimantas Bernotas Arimantas Tamasauskas Dalia Zaliuniene Role of MMP-2 (-1306 C/T) Polymorphism in Pituitary Adenoma Scientifica |
| title | Role of MMP-2 (-1306 C/T) Polymorphism in Pituitary Adenoma |
| title_full | Role of MMP-2 (-1306 C/T) Polymorphism in Pituitary Adenoma |
| title_fullStr | Role of MMP-2 (-1306 C/T) Polymorphism in Pituitary Adenoma |
| title_full_unstemmed | Role of MMP-2 (-1306 C/T) Polymorphism in Pituitary Adenoma |
| title_short | Role of MMP-2 (-1306 C/T) Polymorphism in Pituitary Adenoma |
| title_sort | role of mmp 2 1306 c t polymorphism in pituitary adenoma |
| url | http://dx.doi.org/10.1155/2016/2839697 |
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