Wearable Sensors Measure Ankle Joint Changes of Patients with Parkinson’s Disease before and after Acute Levodopa Challenge
Background. Previous studies found levodopa could improve the activity of the ankle joints of patients with Parkinson’s disease (PD). But ankle joint movement is composed of four motion ranges. The specific changes of four motion ranges in PD remain unknown. Objective. The purpose of this study was...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Parkinson's Disease |
| Online Access: | http://dx.doi.org/10.1155/2020/2976535 |
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| author | Zhuang Wu Xu Jiang Min Zhong Bo Shen Jun Zhu Yang Pan Jingde Dong Pingyi Xu Wenbin Zhang Li Zhang |
| author_facet | Zhuang Wu Xu Jiang Min Zhong Bo Shen Jun Zhu Yang Pan Jingde Dong Pingyi Xu Wenbin Zhang Li Zhang |
| author_sort | Zhuang Wu |
| collection | DOAJ |
| description | Background. Previous studies found levodopa could improve the activity of the ankle joints of patients with Parkinson’s disease (PD). But ankle joint movement is composed of four motion ranges. The specific changes of four motion ranges in PD remain unknown. Objective. The purpose of this study was to decompose the complex ankle joint movement, measure ankle joint changes before and after the acute levodopa challenge test (ALCT), and investigate the effects of these parameters on gait performance. Methods. 29 PD patients and 30 healthy control subjects (HC) completed the Instrumented Stand and Walk (ISAW) test and gait parameters were collected by the JiBuEn gait analysis system. The percentage of improvement of gait data and the UPDRS III in the on-drug condition (ON) were determined with respect to the off-drug condition (OFF). Results. We observed a reduction in the heel strike angle (HS), 3-plantarflexion (3-PF) angle, and 4-dorsiflexion (4-DF) angle of ankle joints. We did not find significant difference in the toe-off angle (TO), 1-plantarflexion (1-PF) angle, and 2-dorsiflexion (2-DF) angle among three groups. Stride length improvement rate was significantly correlated with HS (rs = 0.616, P<0.001) and 3-PF (rs = 0.639, P<0.001) improvement rates. The improvement in the sum of rigidity items (UPDRS motor subsection item 22) was also correlated with HS (rs = 0.389, P=0.037) and 3-PF (rs = 0.373, P=0.046) improvement rates. Conclusions. Exogenous levodopa supplementation can significantly reduce the rigidity of patients with PD, improve their 3-PF and 4-DF of ankle joint kinematic parameters, and ultimately enhance their gait. |
| format | Article |
| id | doaj-art-9d1b8cc5a857444597f4454211031f73 |
| institution | Kabale University |
| issn | 2090-8083 2042-0080 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Parkinson's Disease |
| spelling | doaj-art-9d1b8cc5a857444597f4454211031f732025-02-03T06:44:57ZengWileyParkinson's Disease2090-80832042-00802020-01-01202010.1155/2020/29765352976535Wearable Sensors Measure Ankle Joint Changes of Patients with Parkinson’s Disease before and after Acute Levodopa ChallengeZhuang Wu0Xu Jiang1Min Zhong2Bo Shen3Jun Zhu4Yang Pan5Jingde Dong6Pingyi Xu7Wenbin Zhang8Li Zhang9Department of Geriatrics, Affiliated Brain Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Geriatrics, Affiliated Brain Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Geriatrics, Affiliated Brain Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Geriatrics, Affiliated Brain Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Geriatrics, Affiliated Brain Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Geriatrics, Affiliated Brain Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Geriatrics, Affiliated Brain Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Neurology, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, ChinaDepartment of Neurosurgery, Affiliated Brain Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Geriatrics, Affiliated Brain Hospital of Nanjing Medical University, Nanjing, ChinaBackground. Previous studies found levodopa could improve the activity of the ankle joints of patients with Parkinson’s disease (PD). But ankle joint movement is composed of four motion ranges. The specific changes of four motion ranges in PD remain unknown. Objective. The purpose of this study was to decompose the complex ankle joint movement, measure ankle joint changes before and after the acute levodopa challenge test (ALCT), and investigate the effects of these parameters on gait performance. Methods. 29 PD patients and 30 healthy control subjects (HC) completed the Instrumented Stand and Walk (ISAW) test and gait parameters were collected by the JiBuEn gait analysis system. The percentage of improvement of gait data and the UPDRS III in the on-drug condition (ON) were determined with respect to the off-drug condition (OFF). Results. We observed a reduction in the heel strike angle (HS), 3-plantarflexion (3-PF) angle, and 4-dorsiflexion (4-DF) angle of ankle joints. We did not find significant difference in the toe-off angle (TO), 1-plantarflexion (1-PF) angle, and 2-dorsiflexion (2-DF) angle among three groups. Stride length improvement rate was significantly correlated with HS (rs = 0.616, P<0.001) and 3-PF (rs = 0.639, P<0.001) improvement rates. The improvement in the sum of rigidity items (UPDRS motor subsection item 22) was also correlated with HS (rs = 0.389, P=0.037) and 3-PF (rs = 0.373, P=0.046) improvement rates. Conclusions. Exogenous levodopa supplementation can significantly reduce the rigidity of patients with PD, improve their 3-PF and 4-DF of ankle joint kinematic parameters, and ultimately enhance their gait.http://dx.doi.org/10.1155/2020/2976535 |
| spellingShingle | Zhuang Wu Xu Jiang Min Zhong Bo Shen Jun Zhu Yang Pan Jingde Dong Pingyi Xu Wenbin Zhang Li Zhang Wearable Sensors Measure Ankle Joint Changes of Patients with Parkinson’s Disease before and after Acute Levodopa Challenge Parkinson's Disease |
| title | Wearable Sensors Measure Ankle Joint Changes of Patients with Parkinson’s Disease before and after Acute Levodopa Challenge |
| title_full | Wearable Sensors Measure Ankle Joint Changes of Patients with Parkinson’s Disease before and after Acute Levodopa Challenge |
| title_fullStr | Wearable Sensors Measure Ankle Joint Changes of Patients with Parkinson’s Disease before and after Acute Levodopa Challenge |
| title_full_unstemmed | Wearable Sensors Measure Ankle Joint Changes of Patients with Parkinson’s Disease before and after Acute Levodopa Challenge |
| title_short | Wearable Sensors Measure Ankle Joint Changes of Patients with Parkinson’s Disease before and after Acute Levodopa Challenge |
| title_sort | wearable sensors measure ankle joint changes of patients with parkinson s disease before and after acute levodopa challenge |
| url | http://dx.doi.org/10.1155/2020/2976535 |
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