Spinal Cord Injury Research in Mice: 2008 Review
Spinal cord injury (SCI) is an irreversible condition causing damage to myelinated fiber tracts that carry sensation and motor signals to and from the brain. SCI is also associated with gray matter damage and often life-threatening secondary complications. This mini-review aims to provide the nonspe...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2009.63 |
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| _version_ | 1832545528256135168 |
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| author | Inge Steuer Pierre A. Guertin |
| author_facet | Inge Steuer Pierre A. Guertin |
| author_sort | Inge Steuer |
| collection | DOAJ |
| description | Spinal cord injury (SCI) is an irreversible condition causing damage to myelinated fiber tracts that carry sensation and motor signals to and from the brain. SCI is also associated with gray matter damage and often life-threatening secondary complications. This mini-review aims to provide the nonspecialist reader with a comprehensive description of recent advances made in 2008 using murine models of SCI. A variety of approaches, including advanced genetics and molecular techniques, have allowed a number of key findings in the field of secondary degeneration, repair, regeneration (including insights from peripheral nerve lesion models), metabolic dysfunctions, and pharmacological neuromodulation. |
| format | Article |
| id | doaj-art-9ce055766462417f923bc7bf0e9a3f3c |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-9ce055766462417f923bc7bf0e9a3f3c2025-02-03T07:25:37ZengWileyThe Scientific World Journal1537-744X2009-01-01949049810.1100/tsw.2009.63Spinal Cord Injury Research in Mice: 2008 ReviewInge Steuer0Pierre A. Guertin1Faculty of Medicine, Department of Anatomy and Physiology, Laval University, Quebec City, Quebec, CanadaFaculty of Medicine, Department of Anatomy and Physiology, Laval University, Quebec City, Quebec, CanadaSpinal cord injury (SCI) is an irreversible condition causing damage to myelinated fiber tracts that carry sensation and motor signals to and from the brain. SCI is also associated with gray matter damage and often life-threatening secondary complications. This mini-review aims to provide the nonspecialist reader with a comprehensive description of recent advances made in 2008 using murine models of SCI. A variety of approaches, including advanced genetics and molecular techniques, have allowed a number of key findings in the field of secondary degeneration, repair, regeneration (including insights from peripheral nerve lesion models), metabolic dysfunctions, and pharmacological neuromodulation.http://dx.doi.org/10.1100/tsw.2009.63 |
| spellingShingle | Inge Steuer Pierre A. Guertin Spinal Cord Injury Research in Mice: 2008 Review The Scientific World Journal |
| title | Spinal Cord Injury Research in Mice: 2008 Review |
| title_full | Spinal Cord Injury Research in Mice: 2008 Review |
| title_fullStr | Spinal Cord Injury Research in Mice: 2008 Review |
| title_full_unstemmed | Spinal Cord Injury Research in Mice: 2008 Review |
| title_short | Spinal Cord Injury Research in Mice: 2008 Review |
| title_sort | spinal cord injury research in mice 2008 review |
| url | http://dx.doi.org/10.1100/tsw.2009.63 |
| work_keys_str_mv | AT ingesteuer spinalcordinjuryresearchinmice2008review AT pierreaguertin spinalcordinjuryresearchinmice2008review |