Corticospinal Tract Wiring and Brain Lesion Characteristics in Unilateral Cerebral Palsy: Determinants of Upper Limb Motor and Sensory Function
Brain lesion characteristics (timing, location, and extent) and the type of corticospinal tract (CST) wiring have been proposed as determinants of upper limb (UL) motor function in unilateral cerebral palsy (uCP), yet an investigation of the relative combined impact of these factors on both motor an...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2018/2671613 |
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| author | Cristina Simon-Martinez Ellen Jaspers Lisa Mailleux Els Ortibus Katrijn Klingels Nicole Wenderoth Hilde Feys |
| author_facet | Cristina Simon-Martinez Ellen Jaspers Lisa Mailleux Els Ortibus Katrijn Klingels Nicole Wenderoth Hilde Feys |
| author_sort | Cristina Simon-Martinez |
| collection | DOAJ |
| description | Brain lesion characteristics (timing, location, and extent) and the type of corticospinal tract (CST) wiring have been proposed as determinants of upper limb (UL) motor function in unilateral cerebral palsy (uCP), yet an investigation of the relative combined impact of these factors on both motor and sensory functions is still lacking. Here, we first investigated whether structural brain lesion characteristics could predict the underlying CST wiring and we explored the role of CST wiring and brain lesion characteristics to predict UL motor and sensory functions in uCP. Fifty-two participants with uCP (mean age (SD): 11 y and 3 m (3 y and 10 m)) underwent a single-pulse Transcranial Magnetic Stimulation session to determine CST wiring between the motor cortex and the more affected hand (n=17 contralateral, n=19 ipsilateral, and n=16 bilateral) and an MRI to determine lesion timing (n=34 periventricular (PV) lesion, n=18 corticosubcortical (CSC) lesion), location, and extent. Lesion location and extent were evaluated with a semiquantitative scale. A standardized protocol included UL motor (grip strength, unimanual capacity, and bimanual performance) and sensory measures. A combination of lesion locations (damage to the PLIC and frontal lobe) significantly contributed to differentiate between the CST wiring groups, reclassifying the participants in their original group with 57% of accuracy. Motor and sensory functions were influenced by each of the investigated neurological factors. However, multiple regression analyses showed that motor function was predicted by the CST wiring (more preserved in individuals with contralateral CST (p<0.01)), lesion extent, and damage to the basal ganglia and thalamus. Sensory function was predicted by the combination of a large and later lesion and an ipsilateral or bilateral CST wiring, which led to increased sensory deficits (p<0.05). These novel insights contribute to a better understanding of the underlying pathophysiology of UL function and may be useful to delineate individualized treatment strategies. |
| format | Article |
| id | doaj-art-9cddb60615944fc3881c91069eecc88f |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-9cddb60615944fc3881c91069eecc88f2025-02-03T05:46:12ZengWileyNeural Plasticity2090-59041687-54432018-01-01201810.1155/2018/26716132671613Corticospinal Tract Wiring and Brain Lesion Characteristics in Unilateral Cerebral Palsy: Determinants of Upper Limb Motor and Sensory FunctionCristina Simon-Martinez0Ellen Jaspers1Lisa Mailleux2Els Ortibus3Katrijn Klingels4Nicole Wenderoth5Hilde Feys6Department of Rehabilitation Sciences, KU Leuven-University of Leuven, Leuven, BelgiumDepartment of Rehabilitation Sciences, KU Leuven-University of Leuven, Leuven, BelgiumDepartment of Rehabilitation Sciences, KU Leuven-University of Leuven, Leuven, BelgiumDepartment of Development and Regeneration, KU Leuven-University of Leuven, Leuven, BelgiumDepartment of Rehabilitation Sciences, KU Leuven-University of Leuven, Leuven, BelgiumNeural Control of Movement Lab, Department of Health Sciences and Technology, ETH Zurich, Zurich, SwitzerlandDepartment of Rehabilitation Sciences, KU Leuven-University of Leuven, Leuven, BelgiumBrain lesion characteristics (timing, location, and extent) and the type of corticospinal tract (CST) wiring have been proposed as determinants of upper limb (UL) motor function in unilateral cerebral palsy (uCP), yet an investigation of the relative combined impact of these factors on both motor and sensory functions is still lacking. Here, we first investigated whether structural brain lesion characteristics could predict the underlying CST wiring and we explored the role of CST wiring and brain lesion characteristics to predict UL motor and sensory functions in uCP. Fifty-two participants with uCP (mean age (SD): 11 y and 3 m (3 y and 10 m)) underwent a single-pulse Transcranial Magnetic Stimulation session to determine CST wiring between the motor cortex and the more affected hand (n=17 contralateral, n=19 ipsilateral, and n=16 bilateral) and an MRI to determine lesion timing (n=34 periventricular (PV) lesion, n=18 corticosubcortical (CSC) lesion), location, and extent. Lesion location and extent were evaluated with a semiquantitative scale. A standardized protocol included UL motor (grip strength, unimanual capacity, and bimanual performance) and sensory measures. A combination of lesion locations (damage to the PLIC and frontal lobe) significantly contributed to differentiate between the CST wiring groups, reclassifying the participants in their original group with 57% of accuracy. Motor and sensory functions were influenced by each of the investigated neurological factors. However, multiple regression analyses showed that motor function was predicted by the CST wiring (more preserved in individuals with contralateral CST (p<0.01)), lesion extent, and damage to the basal ganglia and thalamus. Sensory function was predicted by the combination of a large and later lesion and an ipsilateral or bilateral CST wiring, which led to increased sensory deficits (p<0.05). These novel insights contribute to a better understanding of the underlying pathophysiology of UL function and may be useful to delineate individualized treatment strategies.http://dx.doi.org/10.1155/2018/2671613 |
| spellingShingle | Cristina Simon-Martinez Ellen Jaspers Lisa Mailleux Els Ortibus Katrijn Klingels Nicole Wenderoth Hilde Feys Corticospinal Tract Wiring and Brain Lesion Characteristics in Unilateral Cerebral Palsy: Determinants of Upper Limb Motor and Sensory Function Neural Plasticity |
| title | Corticospinal Tract Wiring and Brain Lesion Characteristics in Unilateral Cerebral Palsy: Determinants of Upper Limb Motor and Sensory Function |
| title_full | Corticospinal Tract Wiring and Brain Lesion Characteristics in Unilateral Cerebral Palsy: Determinants of Upper Limb Motor and Sensory Function |
| title_fullStr | Corticospinal Tract Wiring and Brain Lesion Characteristics in Unilateral Cerebral Palsy: Determinants of Upper Limb Motor and Sensory Function |
| title_full_unstemmed | Corticospinal Tract Wiring and Brain Lesion Characteristics in Unilateral Cerebral Palsy: Determinants of Upper Limb Motor and Sensory Function |
| title_short | Corticospinal Tract Wiring and Brain Lesion Characteristics in Unilateral Cerebral Palsy: Determinants of Upper Limb Motor and Sensory Function |
| title_sort | corticospinal tract wiring and brain lesion characteristics in unilateral cerebral palsy determinants of upper limb motor and sensory function |
| url | http://dx.doi.org/10.1155/2018/2671613 |
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