Major Depressive Disorder as a Condition Negatively Impacting Both Mental and Physical Functioning. What to Do When There Is Treatment Resistance?
The objective of this article is to assess the efficacy and safety of diverse therapeutic strategies for treatment-resistant depression (TRD), encompassing both pharmacological and non-pharmacological interventions. Additionally, the review identifies potential avenues for future research within th...
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| Format: | Article |
| Language: | English |
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Nicolaus Copernicus University in Toruń
2025-01-01
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| Series: | Quality in Sport |
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| Online Access: | https://apcz.umk.pl/QS/article/view/57665 |
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| author | Monika Makar Daria Michałka Zuzanna Gałuszka Natalie Papachristoforou Justyna Głowacka Aleksandra Kocjan Emilia Bąk Natalia Tekiela Radosław Chmiel Tomasz Bartuś |
| author_facet | Monika Makar Daria Michałka Zuzanna Gałuszka Natalie Papachristoforou Justyna Głowacka Aleksandra Kocjan Emilia Bąk Natalia Tekiela Radosław Chmiel Tomasz Bartuś |
| author_sort | Monika Makar |
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The objective of this article is to assess the efficacy and safety of diverse therapeutic strategies for treatment-resistant depression (TRD), encompassing both pharmacological and non-pharmacological interventions. Additionally, the review identifies potential avenues for future research within this domain.
The article compares the results of selected studies. We conducted a literature search in November of 2024, using PubMed. Six studies were identified, chosen, and appraised. Among these studies, three are systematic reviews and three are narrative literature reviews.
If it comes to treatment efficacy studies have demonstrated the effectiveness of several strategies. Ketamine and esketamine have shown rapid and substantial efficacy in mitigating the symptoms of TRD. Augmentation with aripiprazole and quetiapine has also been found to enhance the response to antidepressant treatment. The combination of olanzapine and fluoxetine is effective for treating TRD, however, it may be associated with metabolic side effects. Augmentation with lithium, triiodothyronine (T3), and lamotrigine shows promising results, though further research is required to fully evaluate their efficacy and safety in TRD management.
The management of TRD is associated with several challenges. These include the absence of a standardized definition and grading system, which impedes the comparison of research outcomes. The multifactorial nature of TRD further complicates the development of a universal treatment strategy. Summarizing, there are several treatment strategies available for TRD, however, the most effective approach should be personalized for each patient. Ongoing research is critical to advancing our understanding of TRD and developing more effective therapeutic options.
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| format | Article |
| id | doaj-art-9cdbc042eecc49849d4a8e792c666020 |
| institution | Kabale University |
| issn | 2450-3118 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nicolaus Copernicus University in Toruń |
| record_format | Article |
| series | Quality in Sport |
| spelling | doaj-art-9cdbc042eecc49849d4a8e792c6660202025-01-28T08:25:06ZengNicolaus Copernicus University in ToruńQuality in Sport2450-31182025-01-013710.12775/QS.2024.35.57665Major Depressive Disorder as a Condition Negatively Impacting Both Mental and Physical Functioning. What to Do When There Is Treatment Resistance?Monika Makar0https://orcid.org/0009-0009-8023-6964Daria Michałka1https://orcid.org/0009-0009-6812-6543Zuzanna Gałuszka2https://orcid.org/0009-0009-1729-2146Natalie Papachristoforou 3https://orcid.org/0009-0006-8417-3794Justyna Głowacka4https://orcid.org/0009-0009-8289-8822Aleksandra Kocjan5https://orcid.org/0009-0001-5740-6867Emilia Bąk6https://orcid.org/0000-0002-6407-4063Natalia Tekiela7https://orcid.org/0009-0000-5208-251XRadosław Chmiel8https://orcid.org/0009-0002-2726-6207Tomasz Bartuś9https://orcid.org/0009-0000-3980-3191Niepołomickie Centrum Profilaktyczno- Lecznicze, Stefana Batorego 41C, 32-005 NiepołomiceNZOZ „Centrum Zdrowia i Profilaktyki Dąbie” sp. z o. o., Widok 31 street, 31-567 KrakówSPZOZ Hospital in Myślenice, Szpitalna 2 street, 32-400 MyśleniceSP ZOZ MSWiA Hospital in Kraków, Kronikarza Galla 25 street, 30-053 KrakówGabriel Narutowicz Municipal Hospital in Kraków, Prądnicka 35 street, 31-202 KrakówLudwik Rydygier Specialist Hospital, Osiedle Złotej Jesieni 1 street, 31-820 KrakówSP ZOZ MSWiA Hospital in Kraków, Kronikarza Galla 25 street, 30-053 KrakówSP ZOZ MSWiA Hospital in Kraków, Kronikarza Galla 25 street, 30-053 Kraków SP ZOZ MSWiA Hospital in Kraków, Kronikarza Galla 25 street, 30-053 KrakówAndrzej Frycz Modrzewski University in Kraków, Gustawa Herlinga-Grudzińskiego 1 street, 30-705 Kraków The objective of this article is to assess the efficacy and safety of diverse therapeutic strategies for treatment-resistant depression (TRD), encompassing both pharmacological and non-pharmacological interventions. Additionally, the review identifies potential avenues for future research within this domain. The article compares the results of selected studies. We conducted a literature search in November of 2024, using PubMed. Six studies were identified, chosen, and appraised. Among these studies, three are systematic reviews and three are narrative literature reviews. If it comes to treatment efficacy studies have demonstrated the effectiveness of several strategies. Ketamine and esketamine have shown rapid and substantial efficacy in mitigating the symptoms of TRD. Augmentation with aripiprazole and quetiapine has also been found to enhance the response to antidepressant treatment. The combination of olanzapine and fluoxetine is effective for treating TRD, however, it may be associated with metabolic side effects. Augmentation with lithium, triiodothyronine (T3), and lamotrigine shows promising results, though further research is required to fully evaluate their efficacy and safety in TRD management. The management of TRD is associated with several challenges. These include the absence of a standardized definition and grading system, which impedes the comparison of research outcomes. The multifactorial nature of TRD further complicates the development of a universal treatment strategy. Summarizing, there are several treatment strategies available for TRD, however, the most effective approach should be personalized for each patient. Ongoing research is critical to advancing our understanding of TRD and developing more effective therapeutic options. https://apcz.umk.pl/QS/article/view/57665depressiontreatment-resisant depressionmajor depressive disordermood disorderantidepressantaugmentation |
| spellingShingle | Monika Makar Daria Michałka Zuzanna Gałuszka Natalie Papachristoforou Justyna Głowacka Aleksandra Kocjan Emilia Bąk Natalia Tekiela Radosław Chmiel Tomasz Bartuś Major Depressive Disorder as a Condition Negatively Impacting Both Mental and Physical Functioning. What to Do When There Is Treatment Resistance? Quality in Sport depression treatment-resisant depression major depressive disorder mood disorder antidepressant augmentation |
| title | Major Depressive Disorder as a Condition Negatively Impacting Both Mental and Physical Functioning. What to Do When There Is Treatment Resistance? |
| title_full | Major Depressive Disorder as a Condition Negatively Impacting Both Mental and Physical Functioning. What to Do When There Is Treatment Resistance? |
| title_fullStr | Major Depressive Disorder as a Condition Negatively Impacting Both Mental and Physical Functioning. What to Do When There Is Treatment Resistance? |
| title_full_unstemmed | Major Depressive Disorder as a Condition Negatively Impacting Both Mental and Physical Functioning. What to Do When There Is Treatment Resistance? |
| title_short | Major Depressive Disorder as a Condition Negatively Impacting Both Mental and Physical Functioning. What to Do When There Is Treatment Resistance? |
| title_sort | major depressive disorder as a condition negatively impacting both mental and physical functioning what to do when there is treatment resistance |
| topic | depression treatment-resisant depression major depressive disorder mood disorder antidepressant augmentation |
| url | https://apcz.umk.pl/QS/article/view/57665 |
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