An Approach to Differential Diagnosis of Antiphospholipid Antibody Syndrome and Related Conditions
The antiphospholipid antibody syndrome is a systemic, acquired, immune-mediated disorder characterized by episodes of venous, arterial, or microcirculation thrombosis and/or pregnancy abnormalities, associated with the persistent presence of autoantibodies, confirmed at least in two occasions 12 wee...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/341342 |
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| author | Giacomo Emmi Elena Silvestri Danilo Squatrito Lucia Ciucciarelli Anna Maria Cameli Gentian Denas Mario Milco D’Elios Vittorio Pengo Lorenzo Emmi Domenico Prisco |
| author_facet | Giacomo Emmi Elena Silvestri Danilo Squatrito Lucia Ciucciarelli Anna Maria Cameli Gentian Denas Mario Milco D’Elios Vittorio Pengo Lorenzo Emmi Domenico Prisco |
| author_sort | Giacomo Emmi |
| collection | DOAJ |
| description | The antiphospholipid antibody syndrome is a systemic, acquired, immune-mediated disorder characterized by episodes of venous, arterial, or microcirculation thrombosis and/or pregnancy abnormalities, associated with the persistent presence of autoantibodies, confirmed at least in two occasions 12 weeks apart, directed to molecular complexes consisting of phospholipids and proteins. Antiphospholipid antibody syndrome should always be considered as a potential diagnosis especially for young patients presenting with a history of thrombotic events, in particular when they occur without any obvious external trigger or any inherited thrombophilic mutation (even if 2006 criteria do not exclude antiphospholipid antibody syndrome in patients with other inherited or acquired prothrombotic conditions), or for women with recurrent pregnancy losses or later fetal deaths. Many other disorders are able to mimic antiphospholipid antibody syndrome, so a broad range of alternative diagnoses should be investigated and ruled out during clinical workup. |
| format | Article |
| id | doaj-art-9cd95d90cf4e4a59bdb1338b51c2abb7 |
| institution | OA Journals |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-9cd95d90cf4e4a59bdb1338b51c2abb72025-08-20T02:20:19ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/341342341342An Approach to Differential Diagnosis of Antiphospholipid Antibody Syndrome and Related ConditionsGiacomo Emmi0Elena Silvestri1Danilo Squatrito2Lucia Ciucciarelli3Anna Maria Cameli4Gentian Denas5Mario Milco D’Elios6Vittorio Pengo7Lorenzo Emmi8Domenico Prisco9Department of Experimental and Clinical Medicine, University of Florence, 50134 Florence, ItalyDepartment of Experimental and Clinical Medicine, University of Florence, 50134 Florence, ItalyDepartment of Experimental and Clinical Medicine, University of Florence, 50134 Florence, ItalyDepartment of Experimental and Clinical Medicine, University of Florence, 50134 Florence, ItalyDepartment of Experimental and Clinical Medicine, University of Florence, 50134 Florence, ItalyDepartment of Cardiac Thoracic and Vascular Sciences, University of Padua, 35128 Padua, ItalyDepartment of Experimental and Clinical Medicine, University of Florence, 50134 Florence, ItalyDepartment of Cardiac Thoracic and Vascular Sciences, University of Padua, 35128 Padua, ItalySOD Patologia Medica, Center for Autoimmune Systemic Diseases, Behçet Center and Lupus Clinic, AOU Careggi Hospital, 50134 Florence, ItalyDepartment of Experimental and Clinical Medicine, University of Florence, 50134 Florence, ItalyThe antiphospholipid antibody syndrome is a systemic, acquired, immune-mediated disorder characterized by episodes of venous, arterial, or microcirculation thrombosis and/or pregnancy abnormalities, associated with the persistent presence of autoantibodies, confirmed at least in two occasions 12 weeks apart, directed to molecular complexes consisting of phospholipids and proteins. Antiphospholipid antibody syndrome should always be considered as a potential diagnosis especially for young patients presenting with a history of thrombotic events, in particular when they occur without any obvious external trigger or any inherited thrombophilic mutation (even if 2006 criteria do not exclude antiphospholipid antibody syndrome in patients with other inherited or acquired prothrombotic conditions), or for women with recurrent pregnancy losses or later fetal deaths. Many other disorders are able to mimic antiphospholipid antibody syndrome, so a broad range of alternative diagnoses should be investigated and ruled out during clinical workup.http://dx.doi.org/10.1155/2014/341342 |
| spellingShingle | Giacomo Emmi Elena Silvestri Danilo Squatrito Lucia Ciucciarelli Anna Maria Cameli Gentian Denas Mario Milco D’Elios Vittorio Pengo Lorenzo Emmi Domenico Prisco An Approach to Differential Diagnosis of Antiphospholipid Antibody Syndrome and Related Conditions The Scientific World Journal |
| title | An Approach to Differential Diagnosis of Antiphospholipid Antibody Syndrome and Related Conditions |
| title_full | An Approach to Differential Diagnosis of Antiphospholipid Antibody Syndrome and Related Conditions |
| title_fullStr | An Approach to Differential Diagnosis of Antiphospholipid Antibody Syndrome and Related Conditions |
| title_full_unstemmed | An Approach to Differential Diagnosis of Antiphospholipid Antibody Syndrome and Related Conditions |
| title_short | An Approach to Differential Diagnosis of Antiphospholipid Antibody Syndrome and Related Conditions |
| title_sort | approach to differential diagnosis of antiphospholipid antibody syndrome and related conditions |
| url | http://dx.doi.org/10.1155/2014/341342 |
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