Mucosal multivalent NDV-based vaccine provides cross-reactive immune responses against SARS-CoV-2 variants in animal models

Mucosal multivalent NDV-based vaccine provides cross-reactive immune responses against SARS-CoV-2 variants in animal models

IntroductionA new generation of mucosal vaccine against the ever-evolving SARS-CoV-2 is of great value to fight COVID-19. In previous studies, our groups developed a viral vector vaccine based on an avirulent Newcastle disease virus (NDV) expressing the prefusion-stabilized spike protein of SARS-CoV...

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Main Authors: Irene González-Domínguez, Adam Abdeljawad, Tsoi Ying Lai, Marta Boza, Stephen McCroskery, Nicholas Lemus, Stefan Slamanig, Gagandeep Singh, Prajakta Warang, Temima Yellin, Anass Abbad, Juan Manuel Carreño, Victoria Dolange, Jose Luis Martínez-Guevara, Marina Barcena-Varela, Lauren A. Chang, Michael Schotsaert, Florian Krammer, Peter Palese, Weina Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Immunology
Subjects:
transmission-proof
sterilizing immunity
viral shedding
COVID-19
Coronavirus
vector vaccine
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1524477/full
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