Phenotypic Resistance of (MRSA) Clinical Isolates to Some Macrolide Antibiotic Groups
Antimicrobial resistance is one of the most significant global threats to human health in recent times, and it limits the achievement of several of the sustainable development goals. Methicillin-resistant Staphylococcus aureus (MRSA) is among the most essential multidrug-resistant bacterial pathoge...
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middle technical university
2023-12-01
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| Series: | Journal of Techniques |
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| Online Access: | https://journal.mtu.edu.iq/index.php/MTU/article/view/1730 |
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| author | Ali Yaseen Jaleel Samanje Qahtan Adnan Rasheed Rafah Sabah Barrak Afraa Brahim |
| author_facet | Ali Yaseen Jaleel Samanje Qahtan Adnan Rasheed Rafah Sabah Barrak Afraa Brahim |
| author_sort | Ali Yaseen |
| collection | DOAJ |
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Antimicrobial resistance is one of the most significant global threats to human health in recent times, and it limits the achievement of several of the sustainable development goals. Methicillin-resistant Staphylococcus aureus (MRSA) is among the most essential multidrug-resistant bacterial pathogens. The study aimed to determine the prevalence of (MRSA) from different clinical samples to emphasise the suitable treatment. One hundred fifty different clinical samples were collected. All these samples were subjected to classical microbiological testing, which included culturing directly on mannitol salt agar and antibiotic susceptibility test (A.S.T). The results observed that only 32 out of 150 samples of MRSA isolates were identified using cefoxitin 30 (µg) as a screening antibiotic, as suggested by CLSI. These 32 MRSA isolates showed resistance toward penicillin and cefoxitin, high sensitivity against vancomycin, and moderate resistance against doxycycline and azithromycin. Considering the phenotyping resistance toward macrolide antibiotic groups, 10/32 (31.25%) showed S-phenotype,18/32 (52.65%) showed R-phenotype,4/32 (12.5%) showed D-phenotype while no MRSA isolated showed D+ phenotype. This study concludes that inducible clindamycin resistance of S. aureus (MRSA) increases the difficulty of treating S. aureus bacterial infections.
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| format | Article |
| id | doaj-art-9cbe06d6d807424dab6ccdc74b88e1de |
| institution | Kabale University |
| issn | 1818-653X 2708-8383 |
| language | English |
| publishDate | 2023-12-01 |
| publisher | middle technical university |
| record_format | Article |
| series | Journal of Techniques |
| spelling | doaj-art-9cbe06d6d807424dab6ccdc74b88e1de2025-01-19T10:58:59Zengmiddle technical universityJournal of Techniques1818-653X2708-83832023-12-015410.51173/jt.v5i4.1730Phenotypic Resistance of (MRSA) Clinical Isolates to Some Macrolide Antibiotic GroupsAli Yaseen0Jaleel Samanje1Qahtan Adnan Rasheed2Rafah Sabah Barrak3Afraa Brahim4College of Health & Medical Technology - Baghdad, Middle Technical University, Baghdad, IraqCollege of Health & Medical Technology - Baghdad, Middle Technical University, Baghdad, IraqCollege of Health & Medical Technology - Baghdad, Middle Technical University, Baghdad, IraqFaculty of Medicine "Ibn El Jazzar" of Sousse, University of Sousse, Sousse, TunisiaFaculty of Medicine "Ibn El Jazzar" of Sousse, University of Sousse, Sousse, Tunisia Antimicrobial resistance is one of the most significant global threats to human health in recent times, and it limits the achievement of several of the sustainable development goals. Methicillin-resistant Staphylococcus aureus (MRSA) is among the most essential multidrug-resistant bacterial pathogens. The study aimed to determine the prevalence of (MRSA) from different clinical samples to emphasise the suitable treatment. One hundred fifty different clinical samples were collected. All these samples were subjected to classical microbiological testing, which included culturing directly on mannitol salt agar and antibiotic susceptibility test (A.S.T). The results observed that only 32 out of 150 samples of MRSA isolates were identified using cefoxitin 30 (µg) as a screening antibiotic, as suggested by CLSI. These 32 MRSA isolates showed resistance toward penicillin and cefoxitin, high sensitivity against vancomycin, and moderate resistance against doxycycline and azithromycin. Considering the phenotyping resistance toward macrolide antibiotic groups, 10/32 (31.25%) showed S-phenotype,18/32 (52.65%) showed R-phenotype,4/32 (12.5%) showed D-phenotype while no MRSA isolated showed D+ phenotype. This study concludes that inducible clindamycin resistance of S. aureus (MRSA) increases the difficulty of treating S. aureus bacterial infections. https://journal.mtu.edu.iq/index.php/MTU/article/view/1730Burn SamplesCefoxitinD-PhenotypeErythromycinMRSA |
| spellingShingle | Ali Yaseen Jaleel Samanje Qahtan Adnan Rasheed Rafah Sabah Barrak Afraa Brahim Phenotypic Resistance of (MRSA) Clinical Isolates to Some Macrolide Antibiotic Groups Journal of Techniques Burn Samples Cefoxitin D-Phenotype Erythromycin MRSA |
| title | Phenotypic Resistance of (MRSA) Clinical Isolates to Some Macrolide Antibiotic Groups |
| title_full | Phenotypic Resistance of (MRSA) Clinical Isolates to Some Macrolide Antibiotic Groups |
| title_fullStr | Phenotypic Resistance of (MRSA) Clinical Isolates to Some Macrolide Antibiotic Groups |
| title_full_unstemmed | Phenotypic Resistance of (MRSA) Clinical Isolates to Some Macrolide Antibiotic Groups |
| title_short | Phenotypic Resistance of (MRSA) Clinical Isolates to Some Macrolide Antibiotic Groups |
| title_sort | phenotypic resistance of mrsa clinical isolates to some macrolide antibiotic groups |
| topic | Burn Samples Cefoxitin D-Phenotype Erythromycin MRSA |
| url | https://journal.mtu.edu.iq/index.php/MTU/article/view/1730 |
| work_keys_str_mv | AT aliyaseen phenotypicresistanceofmrsaclinicalisolatestosomemacrolideantibioticgroups AT jaleelsamanje phenotypicresistanceofmrsaclinicalisolatestosomemacrolideantibioticgroups AT qahtanadnanrasheed phenotypicresistanceofmrsaclinicalisolatestosomemacrolideantibioticgroups AT rafahsabahbarrak phenotypicresistanceofmrsaclinicalisolatestosomemacrolideantibioticgroups AT afraabrahim phenotypicresistanceofmrsaclinicalisolatestosomemacrolideantibioticgroups |