Interruption of mitochondrial symbiosis is associated with the development of osteoporosis
Mitochondria maintain bacterial traits because of their endosymbiotic origins, yet the host cell recognizes them as non-threatening since the organelles are compartmentalized. Nevertheless, the controlled release of mitochondrial components into the cytoplasm can initiate cell death, activate innate...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2025.1488489/full |
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| author | Haoling Zhang Haoling Zhang Haoling Zhang Rui Zhao Xuemei Wang Yaqian Qi Doblin Sandai Wei Wang Zhijing Song Zhijing Song Qiudong Liang |
| author_facet | Haoling Zhang Haoling Zhang Haoling Zhang Rui Zhao Xuemei Wang Yaqian Qi Doblin Sandai Wei Wang Zhijing Song Zhijing Song Qiudong Liang |
| author_sort | Haoling Zhang |
| collection | DOAJ |
| description | Mitochondria maintain bacterial traits because of their endosymbiotic origins, yet the host cell recognizes them as non-threatening since the organelles are compartmentalized. Nevertheless, the controlled release of mitochondrial components into the cytoplasm can initiate cell death, activate innate immunity, and provoke inflammation. This selective interruption of endosymbiosis as early as 2 billion years ago allowed mitochondria to become intracellular signaling hubs. Recent studies have found that the interruption of mitochondrial symbiosis may be closely related to the occurrence of various diseases, especially osteoporosis (OP). OP is a systemic bone disease characterized by reduced bone mass, impaired bone microstructure, elevated bone fragility, and susceptibility to fracture. The interruption of intra-mitochondrial symbiosis affects the energy metabolism of bone cells, leads to the imbalance of bone formation and bone absorption, and promotes the occurrence of osteoporosis. In this paper, we reviewed the mechanism of mitochondrial intersymbiosis interruption in OP, discussed the relationship between mitochondrial intersymbiosis interruption and bone marrow mesenchymal stem cells, osteoblasts and osteoclasts, as well as the inheritance and adaptation in the evolutionary process, and prospected the future research direction to provide new ideas for clinical treatment. |
| format | Article |
| id | doaj-art-9cbc83a0998b48288aaab4159ce29d18 |
| institution | Kabale University |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj-art-9cbc83a0998b48288aaab4159ce29d182025-02-03T05:11:53ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-02-011610.3389/fendo.2025.14884891488489Interruption of mitochondrial symbiosis is associated with the development of osteoporosisHaoling Zhang0Haoling Zhang1Haoling Zhang2Rui Zhao3Xuemei Wang4Yaqian Qi5Doblin Sandai6Wei Wang7Zhijing Song8Zhijing Song9Qiudong Liang10Department of Spinal and Trauma Surgery, The First Affiliated Hospital of Xinxiang Medical College, Xinxiang, Henan, ChinaDepartment of Biomedical Sciences, Advanced Medical and Dental Institute, Universiti Sains Malaysia, Penang, MalaysiaSchool of Public Health, Gansu University of Traditional Chinese Medicine, Lanzhou, ChinaClinical College of Chinese Medicine, Gansu University of Chinese Medicine, Lanzhou, ChinaCollege of Pharmacy, Gansu University of Traditional Chinese Medicine, Lanzhou, ChinaClinical College of Chinese Medicine, Gansu University of Chinese Medicine, Lanzhou, ChinaDepartment of Biomedical Sciences, Advanced Medical and Dental Institute, Universiti Sains Malaysia, Penang, MalaysiaCollege of Acupuncture and Massage, Gansu University of Traditional Chinese Medicine, Lanzhou, ChinaClinical College of Chinese Medicine, Gansu University of Chinese Medicine, Lanzhou, ChinaKey Laboratory of Dunhuang Medicine and Transformation, Ministry of Education, Lanzhou, ChinaDepartment of Spinal and Trauma Surgery, The First Affiliated Hospital of Xinxiang Medical College, Xinxiang, Henan, ChinaMitochondria maintain bacterial traits because of their endosymbiotic origins, yet the host cell recognizes them as non-threatening since the organelles are compartmentalized. Nevertheless, the controlled release of mitochondrial components into the cytoplasm can initiate cell death, activate innate immunity, and provoke inflammation. This selective interruption of endosymbiosis as early as 2 billion years ago allowed mitochondria to become intracellular signaling hubs. Recent studies have found that the interruption of mitochondrial symbiosis may be closely related to the occurrence of various diseases, especially osteoporosis (OP). OP is a systemic bone disease characterized by reduced bone mass, impaired bone microstructure, elevated bone fragility, and susceptibility to fracture. The interruption of intra-mitochondrial symbiosis affects the energy metabolism of bone cells, leads to the imbalance of bone formation and bone absorption, and promotes the occurrence of osteoporosis. In this paper, we reviewed the mechanism of mitochondrial intersymbiosis interruption in OP, discussed the relationship between mitochondrial intersymbiosis interruption and bone marrow mesenchymal stem cells, osteoblasts and osteoclasts, as well as the inheritance and adaptation in the evolutionary process, and prospected the future research direction to provide new ideas for clinical treatment.https://www.frontiersin.org/articles/10.3389/fendo.2025.1488489/fullinterruption of mitochondrial endosymbiosisosteoporosiscytoplasmic signalbone tissue cellsheredityADAPT |
| spellingShingle | Haoling Zhang Haoling Zhang Haoling Zhang Rui Zhao Xuemei Wang Yaqian Qi Doblin Sandai Wei Wang Zhijing Song Zhijing Song Qiudong Liang Interruption of mitochondrial symbiosis is associated with the development of osteoporosis Frontiers in Endocrinology interruption of mitochondrial endosymbiosis osteoporosis cytoplasmic signal bone tissue cells heredity ADAPT |
| title | Interruption of mitochondrial symbiosis is associated with the development of osteoporosis |
| title_full | Interruption of mitochondrial symbiosis is associated with the development of osteoporosis |
| title_fullStr | Interruption of mitochondrial symbiosis is associated with the development of osteoporosis |
| title_full_unstemmed | Interruption of mitochondrial symbiosis is associated with the development of osteoporosis |
| title_short | Interruption of mitochondrial symbiosis is associated with the development of osteoporosis |
| title_sort | interruption of mitochondrial symbiosis is associated with the development of osteoporosis |
| topic | interruption of mitochondrial endosymbiosis osteoporosis cytoplasmic signal bone tissue cells heredity ADAPT |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2025.1488489/full |
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