Integrated analysis of WGCNA and machine learning identified diagnostic biomarkers in trauma-induced coagulopathy

Integrated analysis of WGCNA and machine learning identified diagnostic biomarkers in trauma-induced coagulopathy

Abstract Despite advancements in trauma care, uncontrolled hemorrhage and trauma-induced coagulopathy (TIC) remain the leading causes of preventable deaths after trauma. Understanding the genetic underpinnings and molecular mechanisms of TIC is crucial for developing effective diagnostic and therape...

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Main Authors: Qingsong Chen, Tao Li, Tao Zhang, Yue Zhou, Weifeng Huang, Hui Li, Li Shi, Jianxiao Li, Qi Zhang, Man Ma, Pan Wang, Hui Hu, Gongbin Wei, Jiangxia Xiang, Yuan Cheng, Jun Yang, Guangbin Huang, Yongming Li, Dingyuan Du
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Trauma-induced coagulopathy
Differential gene expression
Weighted gene coexpression network analysis
Machine learning algorithms
Biomarker identification
Immunoinfiltration analysis
Online Access:https://doi.org/10.1038/s41598-025-10323-4
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