The role of viral interaction in household transmission of symptomatic influenza and respiratory syncytial virus
Abstract The role of viral interaction—where one virus enhances or inhibits infection with another virus—in respiratory virus transmission is not well characterized. This study used data from 4029 total participants from 957 households who participated in a prospective household cohort study in Sout...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-025-56285-z |
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| author | Jessica C. Ibiebele Elie-Tino Godonou Amy P. Callear Matthew R. Smith Rachel Truscon Emileigh Johnson Marisa C. Eisenberg Adam S. Lauring Arnold S. Monto Sarah Cobey Emily T. Martin |
| author_facet | Jessica C. Ibiebele Elie-Tino Godonou Amy P. Callear Matthew R. Smith Rachel Truscon Emileigh Johnson Marisa C. Eisenberg Adam S. Lauring Arnold S. Monto Sarah Cobey Emily T. Martin |
| author_sort | Jessica C. Ibiebele |
| collection | DOAJ |
| description | Abstract The role of viral interaction—where one virus enhances or inhibits infection with another virus—in respiratory virus transmission is not well characterized. This study used data from 4029 total participants from 957 households who participated in a prospective household cohort study in Southeast Michigan, U.S.A to examine how viral coinfection and cocirculation may impact transmission of symptomatic influenza and respiratory syncytial virus infections. We utilized multivariable mixed effects regression to estimate transmission risk when index cases were coinfected with multiple viruses and when viruses cocirculated within households. This analysis included 201 coinfections involving influenza A virus, 67 involving influenza B virus, and 181 involving respiratory syncytial virus. We show that exposure to symptomatic coinfected index cases was associated with reduced risk of influenza A virus and respiratory syncytial virus transmission compared to exposure to singly infected cases, while infection with another virus was associated with increased risk of acquisition of these viruses. Exposure to coinfected cases among contacts infected with other viruses was associated with increased risk of influenza B virus acquisition. These results suggest that viral interaction may impact symptomatic transmission of these viruses. |
| format | Article |
| id | doaj-art-9c8bdabd1ca1441aa7a9ac5eb1d9c9d4 |
| institution | Kabale University |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-9c8bdabd1ca1441aa7a9ac5eb1d9c9d42025-02-02T12:31:15ZengNature PortfolioNature Communications2041-17232025-02-0116111210.1038/s41467-025-56285-zThe role of viral interaction in household transmission of symptomatic influenza and respiratory syncytial virusJessica C. Ibiebele0Elie-Tino Godonou1Amy P. Callear2Matthew R. Smith3Rachel Truscon4Emileigh Johnson5Marisa C. Eisenberg6Adam S. Lauring7Arnold S. Monto8Sarah Cobey9Emily T. Martin10Department of Epidemiology, University of MichiganDepartment of Epidemiology, University of MichiganDepartment of Epidemiology, University of MichiganDepartment of Epidemiology, University of MichiganDepartment of Epidemiology, University of MichiganDepartment of Epidemiology, University of MichiganDepartment of Epidemiology, University of MichiganDepartment of Internal Medicine, University of MichiganDepartment of Epidemiology, University of MichiganDepartment of Ecology & Evolution, University of ChicagoDepartment of Epidemiology, University of MichiganAbstract The role of viral interaction—where one virus enhances or inhibits infection with another virus—in respiratory virus transmission is not well characterized. This study used data from 4029 total participants from 957 households who participated in a prospective household cohort study in Southeast Michigan, U.S.A to examine how viral coinfection and cocirculation may impact transmission of symptomatic influenza and respiratory syncytial virus infections. We utilized multivariable mixed effects regression to estimate transmission risk when index cases were coinfected with multiple viruses and when viruses cocirculated within households. This analysis included 201 coinfections involving influenza A virus, 67 involving influenza B virus, and 181 involving respiratory syncytial virus. We show that exposure to symptomatic coinfected index cases was associated with reduced risk of influenza A virus and respiratory syncytial virus transmission compared to exposure to singly infected cases, while infection with another virus was associated with increased risk of acquisition of these viruses. Exposure to coinfected cases among contacts infected with other viruses was associated with increased risk of influenza B virus acquisition. These results suggest that viral interaction may impact symptomatic transmission of these viruses.https://doi.org/10.1038/s41467-025-56285-z |
| spellingShingle | Jessica C. Ibiebele Elie-Tino Godonou Amy P. Callear Matthew R. Smith Rachel Truscon Emileigh Johnson Marisa C. Eisenberg Adam S. Lauring Arnold S. Monto Sarah Cobey Emily T. Martin The role of viral interaction in household transmission of symptomatic influenza and respiratory syncytial virus Nature Communications |
| title | The role of viral interaction in household transmission of symptomatic influenza and respiratory syncytial virus |
| title_full | The role of viral interaction in household transmission of symptomatic influenza and respiratory syncytial virus |
| title_fullStr | The role of viral interaction in household transmission of symptomatic influenza and respiratory syncytial virus |
| title_full_unstemmed | The role of viral interaction in household transmission of symptomatic influenza and respiratory syncytial virus |
| title_short | The role of viral interaction in household transmission of symptomatic influenza and respiratory syncytial virus |
| title_sort | role of viral interaction in household transmission of symptomatic influenza and respiratory syncytial virus |
| url | https://doi.org/10.1038/s41467-025-56285-z |
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