Linking the brain and bone through fat
Over the past years, bone and adipose tissue have gained interest from researchers in the light of their secretory profiles, being able to produce active molecules, with the final effect of regulating energy homeostasis. Both adipocytes and osteoblasts originate in the pluripotent mesenchymal stem c...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-04-01
|
| Series: | Journal of Mind and Medical Sciences |
| Subjects: | |
| Online Access: | https://scholar.valpo.edu/cgi/viewcontent.cgi?article=1259&context=jmms |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850273876496351232 |
|---|---|
| author | Elisabeta Malinici Anca Sirbu Miruna Popa Simona Fica |
| author_facet | Elisabeta Malinici Anca Sirbu Miruna Popa Simona Fica |
| author_sort | Elisabeta Malinici |
| collection | DOAJ |
| description | Over the past years, bone and adipose tissue have gained interest from researchers in the light of their secretory profiles, being able to produce active molecules, with the final effect of regulating energy homeostasis. Both adipocytes and osteoblasts originate in the pluripotent mesenchymal stem cell and this common origin has been proposed as the core of the fat-bone relationship. The central nervous system might be the third player in this association, capable of integrating signals. Numerous adipose tissue secreted factors that influence energy homeostasis and bone have been described: leptin, adiponectin, lipocalin 2, and inflammatory cytokines (e.g. IL-1, IL-6 and TNF-α). Similarly, osteocalcin, the most abundant bone protein, has been shown to elicit numerous central and peripheral endocrine functions. In this paper, we provide a review of the current literature regarding the bone-adipose tissue-central nervous system axis and a brief description of the several underlying molecular mechanisms. |
| format | Article |
| id | doaj-art-9c8a5cd04c7e4d49a57784ea97d744a8 |
| institution | OA Journals |
| issn | 2392-7674 2392-7674 |
| language | English |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Mind and Medical Sciences |
| spelling | doaj-art-9c8a5cd04c7e4d49a57784ea97d744a82025-08-20T01:51:20ZengMDPI AGJournal of Mind and Medical Sciences2392-76742392-76742021-04-0181172610.22543/7674.81.P1726Linking the brain and bone through fatElisabeta Malinici0Anca Sirbu1Miruna Popa2Simona Fica3CAROL DAVILA UNIVERSITY OF MEDICINE AND PHARMACY, BUCHAREST, ROMANIACAROL DAVILA UNIVERSITY OF MEDICINE AND PHARMACY, BUCHAREST, ROMANIACAROL DAVILA UNIVERSITY OF MEDICINE AND PHARMACY, BUCHAREST, ROMANIACAROL DAVILA UNIVERSITY OF MEDICINE AND PHARMACY, BUCHAREST, ROMANIAOver the past years, bone and adipose tissue have gained interest from researchers in the light of their secretory profiles, being able to produce active molecules, with the final effect of regulating energy homeostasis. Both adipocytes and osteoblasts originate in the pluripotent mesenchymal stem cell and this common origin has been proposed as the core of the fat-bone relationship. The central nervous system might be the third player in this association, capable of integrating signals. Numerous adipose tissue secreted factors that influence energy homeostasis and bone have been described: leptin, adiponectin, lipocalin 2, and inflammatory cytokines (e.g. IL-1, IL-6 and TNF-α). Similarly, osteocalcin, the most abundant bone protein, has been shown to elicit numerous central and peripheral endocrine functions. In this paper, we provide a review of the current literature regarding the bone-adipose tissue-central nervous system axis and a brief description of the several underlying molecular mechanisms.https://scholar.valpo.edu/cgi/viewcontent.cgi?article=1259&context=jmmsadipose tissueboneleptinadiponectinosteocalcin |
| spellingShingle | Elisabeta Malinici Anca Sirbu Miruna Popa Simona Fica Linking the brain and bone through fat Journal of Mind and Medical Sciences adipose tissue bone leptin adiponectin osteocalcin |
| title | Linking the brain and bone through fat |
| title_full | Linking the brain and bone through fat |
| title_fullStr | Linking the brain and bone through fat |
| title_full_unstemmed | Linking the brain and bone through fat |
| title_short | Linking the brain and bone through fat |
| title_sort | linking the brain and bone through fat |
| topic | adipose tissue bone leptin adiponectin osteocalcin |
| url | https://scholar.valpo.edu/cgi/viewcontent.cgi?article=1259&context=jmms |
| work_keys_str_mv | AT elisabetamalinici linkingthebrainandbonethroughfat AT ancasirbu linkingthebrainandbonethroughfat AT mirunapopa linkingthebrainandbonethroughfat AT simonafica linkingthebrainandbonethroughfat |