Anti-Tick-Bourne Encephalitis IgM Intrathecal Synthesis as a Prediction Marker in Tick-Borne Encephalitis Patients
The aim of this study was to evaluate the usefulness of IgM anti-Tick-Borne Encephalitis (anti-TBE) intrathecal synthesis in the diagnosis and prediction of the clinical course of the disease. Thirty-six patients were included in the study (patients reported symptoms such as fever, headache, fatigue...
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MDPI AG
2025-01-01
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| author | Piotr Czupryna Sambor Grygorczuk Agnieszka Siemieniako-Werszko Jakub Okrzeja Justyna Dunaj-Małyszko Justyna Adamczuk Sławomir Pancewicz Joanna Zajkowska Karolina Narejko Joanna Oklińska Gabriela Trojan Anna Moniuszko-Malinowska |
| author_facet | Piotr Czupryna Sambor Grygorczuk Agnieszka Siemieniako-Werszko Jakub Okrzeja Justyna Dunaj-Małyszko Justyna Adamczuk Sławomir Pancewicz Joanna Zajkowska Karolina Narejko Joanna Oklińska Gabriela Trojan Anna Moniuszko-Malinowska |
| author_sort | Piotr Czupryna |
| collection | DOAJ |
| description | The aim of this study was to evaluate the usefulness of IgM anti-Tick-Borne Encephalitis (anti-TBE) intrathecal synthesis in the diagnosis and prediction of the clinical course of the disease. Thirty-six patients were included in the study (patients reported symptoms such as fever, headache, fatigue, and nausea/vomiting). CRP, White Blood Cells (WBC), pleocytosis, Cerebrospinal Fluid (CSF) protein concentration, CSF albumin concentration, serum IgM, serum IgG, CSF IgM, CSF IgG, IgM Index, IgG Index, and IgG Index/IgM Index ratio were the parameters which were examined in the individuals. An analysis of correlation presented statistical significance between IgM Index and pleocytosis and protein concentration in CSF in the whole group of individuals. IgM Index and IgG Index/IgM Index ratio may be used in the prediction of severity of TBE. The most probable link between the IgM intrathecal production and severity of TBE may be a result of delayed seroconversion to IgG, and therefore not an adequate response to the virus presence. |
| format | Article |
| id | doaj-art-9c741d7bd64f4e99bab3e6dbdacb1a33 |
| institution | Kabale University |
| issn | 2076-2607 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj-art-9c741d7bd64f4e99bab3e6dbdacb1a332025-01-24T13:43:05ZengMDPI AGMicroorganisms2076-26072025-01-0113121310.3390/microorganisms13010213Anti-Tick-Bourne Encephalitis IgM Intrathecal Synthesis as a Prediction Marker in Tick-Borne Encephalitis PatientsPiotr Czupryna0Sambor Grygorczuk1Agnieszka Siemieniako-Werszko2Jakub Okrzeja3Justyna Dunaj-Małyszko4Justyna Adamczuk5Sławomir Pancewicz6Joanna Zajkowska7Karolina Narejko8Joanna Oklińska9Gabriela Trojan10Anna Moniuszko-Malinowska11Department of Infectious Diseases and Neuroinfections, Medical University of Bialystok, 15-540 Bialystok, PolandDepartment of Infectious Diseases and Neuroinfections, Medical University of Bialystok, 15-540 Bialystok, PolandDepartment of Infectious Diseases and Neuroinfections, Medical University of Bialystok, 15-540 Bialystok, PolandDepartment of Infectious Diseases and Neuroinfections, Medical University of Bialystok, 15-540 Bialystok, PolandDepartment of Infectious Diseases and Neuroinfections, Medical University of Bialystok, 15-540 Bialystok, PolandDepartment of Infectious Diseases and Neuroinfections, Medical University of Bialystok, 15-540 Bialystok, PolandDepartment of Infectious Diseases and Neuroinfections, Medical University of Bialystok, 15-540 Bialystok, PolandDepartment of Infectious Diseases and Neuroinfections, Medical University of Bialystok, 15-540 Bialystok, PolandDepartment of Infectious Diseases and Neuroinfections, Medical University of Bialystok, 15-540 Bialystok, PolandDepartment of Infectious Diseases and Neuroinfections, Medical University of Bialystok, 15-540 Bialystok, PolandDepartment of Infectious Diseases and Neuroinfections, Medical University of Bialystok, 15-540 Bialystok, PolandDepartment of Infectious Diseases and Neuroinfections, Medical University of Bialystok, 15-540 Bialystok, PolandThe aim of this study was to evaluate the usefulness of IgM anti-Tick-Borne Encephalitis (anti-TBE) intrathecal synthesis in the diagnosis and prediction of the clinical course of the disease. Thirty-six patients were included in the study (patients reported symptoms such as fever, headache, fatigue, and nausea/vomiting). CRP, White Blood Cells (WBC), pleocytosis, Cerebrospinal Fluid (CSF) protein concentration, CSF albumin concentration, serum IgM, serum IgG, CSF IgM, CSF IgG, IgM Index, IgG Index, and IgG Index/IgM Index ratio were the parameters which were examined in the individuals. An analysis of correlation presented statistical significance between IgM Index and pleocytosis and protein concentration in CSF in the whole group of individuals. IgM Index and IgG Index/IgM Index ratio may be used in the prediction of severity of TBE. The most probable link between the IgM intrathecal production and severity of TBE may be a result of delayed seroconversion to IgG, and therefore not an adequate response to the virus presence.https://www.mdpi.com/2076-2607/13/1/213tick-borne encephalitisTBEintrathecal synthesisIgMCSF |
| spellingShingle | Piotr Czupryna Sambor Grygorczuk Agnieszka Siemieniako-Werszko Jakub Okrzeja Justyna Dunaj-Małyszko Justyna Adamczuk Sławomir Pancewicz Joanna Zajkowska Karolina Narejko Joanna Oklińska Gabriela Trojan Anna Moniuszko-Malinowska Anti-Tick-Bourne Encephalitis IgM Intrathecal Synthesis as a Prediction Marker in Tick-Borne Encephalitis Patients Microorganisms tick-borne encephalitis TBE intrathecal synthesis IgM CSF |
| title | Anti-Tick-Bourne Encephalitis IgM Intrathecal Synthesis as a Prediction Marker in Tick-Borne Encephalitis Patients |
| title_full | Anti-Tick-Bourne Encephalitis IgM Intrathecal Synthesis as a Prediction Marker in Tick-Borne Encephalitis Patients |
| title_fullStr | Anti-Tick-Bourne Encephalitis IgM Intrathecal Synthesis as a Prediction Marker in Tick-Borne Encephalitis Patients |
| title_full_unstemmed | Anti-Tick-Bourne Encephalitis IgM Intrathecal Synthesis as a Prediction Marker in Tick-Borne Encephalitis Patients |
| title_short | Anti-Tick-Bourne Encephalitis IgM Intrathecal Synthesis as a Prediction Marker in Tick-Borne Encephalitis Patients |
| title_sort | anti tick bourne encephalitis igm intrathecal synthesis as a prediction marker in tick borne encephalitis patients |
| topic | tick-borne encephalitis TBE intrathecal synthesis IgM CSF |
| url | https://www.mdpi.com/2076-2607/13/1/213 |
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