The Application of Natural Camel Milk Products to Treat Autism-Spectrum Disorders: Risk Assessment and Meta-Analysis of Randomized Clinical Trials
Camel milk is better tolerated than the milk of other ruminants, potentially expanding its consumer appeal. It also contains essential vitamins, minerals, and immunoglobulins, providing the milk with antioxidant, antibacterial, and antiviral properties. These properties may reduce oxidative stress i...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-01-01
|
| Series: | Bioinorganic Chemistry and Applications |
| Online Access: | http://dx.doi.org/10.1155/2022/6422208 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850179585574961152 |
|---|---|
| author | Mahmoud Kandeel Wael El-Deeb |
| author_facet | Mahmoud Kandeel Wael El-Deeb |
| author_sort | Mahmoud Kandeel |
| collection | DOAJ |
| description | Camel milk is better tolerated than the milk of other ruminants, potentially expanding its consumer appeal. It also contains essential vitamins, minerals, and immunoglobulins, providing the milk with antioxidant, antibacterial, and antiviral properties. These properties may reduce oxidative stress in camel milk consumers, ameliorating many conditions, including those of the CNS, such as autism spectrum disorders (ASDs). We performed a meta-analysis of randomized controlled trials (RCTs) in which camel milk administration (boiled or raw) was examined as an ASD treatment intervention. The primary endpoint was participants’ total autism scores, determined using the Childhood Autistic Responsiveness Scale (CARS). A comparison of the responsiveness in these ASD intervention groups yielded a mean difference (MD) of 1.99 (0.89, 3.08) in those consuming boiled camel milk, MD = 2.77 (1.92, 3.61) in raw camel milk consumers, and MD = −1.02 (−0.10, 2.13) in cow milk consumers. Heterogeneity was notably low among the examined studies. Treatment of ASD with raw and boiled camel milk resulted in significantly lower CARS scores than the placebo. Our findings support the development of larger, more populated RCTs to establish camel milk’s overall potential as a therapeutic intervention for CNS disorders. |
| format | Article |
| id | doaj-art-9c730554f00a447ca4e577d1cd577799 |
| institution | OA Journals |
| issn | 1687-479X |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Bioinorganic Chemistry and Applications |
| spelling | doaj-art-9c730554f00a447ca4e577d1cd5777992025-08-20T02:18:28ZengWileyBioinorganic Chemistry and Applications1687-479X2022-01-01202210.1155/2022/6422208The Application of Natural Camel Milk Products to Treat Autism-Spectrum Disorders: Risk Assessment and Meta-Analysis of Randomized Clinical TrialsMahmoud Kandeel0Wael El-Deeb1Department of Biomedical SciencesDepartment of Clinical SciencesCamel milk is better tolerated than the milk of other ruminants, potentially expanding its consumer appeal. It also contains essential vitamins, minerals, and immunoglobulins, providing the milk with antioxidant, antibacterial, and antiviral properties. These properties may reduce oxidative stress in camel milk consumers, ameliorating many conditions, including those of the CNS, such as autism spectrum disorders (ASDs). We performed a meta-analysis of randomized controlled trials (RCTs) in which camel milk administration (boiled or raw) was examined as an ASD treatment intervention. The primary endpoint was participants’ total autism scores, determined using the Childhood Autistic Responsiveness Scale (CARS). A comparison of the responsiveness in these ASD intervention groups yielded a mean difference (MD) of 1.99 (0.89, 3.08) in those consuming boiled camel milk, MD = 2.77 (1.92, 3.61) in raw camel milk consumers, and MD = −1.02 (−0.10, 2.13) in cow milk consumers. Heterogeneity was notably low among the examined studies. Treatment of ASD with raw and boiled camel milk resulted in significantly lower CARS scores than the placebo. Our findings support the development of larger, more populated RCTs to establish camel milk’s overall potential as a therapeutic intervention for CNS disorders.http://dx.doi.org/10.1155/2022/6422208 |
| spellingShingle | Mahmoud Kandeel Wael El-Deeb The Application of Natural Camel Milk Products to Treat Autism-Spectrum Disorders: Risk Assessment and Meta-Analysis of Randomized Clinical Trials Bioinorganic Chemistry and Applications |
| title | The Application of Natural Camel Milk Products to Treat Autism-Spectrum Disorders: Risk Assessment and Meta-Analysis of Randomized Clinical Trials |
| title_full | The Application of Natural Camel Milk Products to Treat Autism-Spectrum Disorders: Risk Assessment and Meta-Analysis of Randomized Clinical Trials |
| title_fullStr | The Application of Natural Camel Milk Products to Treat Autism-Spectrum Disorders: Risk Assessment and Meta-Analysis of Randomized Clinical Trials |
| title_full_unstemmed | The Application of Natural Camel Milk Products to Treat Autism-Spectrum Disorders: Risk Assessment and Meta-Analysis of Randomized Clinical Trials |
| title_short | The Application of Natural Camel Milk Products to Treat Autism-Spectrum Disorders: Risk Assessment and Meta-Analysis of Randomized Clinical Trials |
| title_sort | application of natural camel milk products to treat autism spectrum disorders risk assessment and meta analysis of randomized clinical trials |
| url | http://dx.doi.org/10.1155/2022/6422208 |
| work_keys_str_mv | AT mahmoudkandeel theapplicationofnaturalcamelmilkproductstotreatautismspectrumdisordersriskassessmentandmetaanalysisofrandomizedclinicaltrials AT waeleldeeb theapplicationofnaturalcamelmilkproductstotreatautismspectrumdisordersriskassessmentandmetaanalysisofrandomizedclinicaltrials AT mahmoudkandeel applicationofnaturalcamelmilkproductstotreatautismspectrumdisordersriskassessmentandmetaanalysisofrandomizedclinicaltrials AT waeleldeeb applicationofnaturalcamelmilkproductstotreatautismspectrumdisordersriskassessmentandmetaanalysisofrandomizedclinicaltrials |