Treatment of a patient with Kawasaki disease associated with selective IgA deficiency by continuous infusion of cyclosporine A without intravenous immunoglobulin
Intravenous immunoglobulin therapy is standard for Kawasaki disease (KD) treatment; however, anaphylactic reactions to immunoglobulins are a risk in KD patients with selective IgA deficiency (sIgAD). The therapy for KD associated with sIgAD has not been established. The IgA immune response is...
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| Format: | Article |
| Language: | English |
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Hacettepe University Institute of Child Health
2016-12-01
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| Series: | The Turkish Journal of Pediatrics |
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| Online Access: | https://turkjpediatr.org/article/view/1178 |
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| _version_ | 1850237216181190656 |
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| author | Tatsuya Anzai Takaomi Minami Tomoyuki Sato Sadahiro Furui Takanori Yamagata |
| author_facet | Tatsuya Anzai Takaomi Minami Tomoyuki Sato Sadahiro Furui Takanori Yamagata |
| author_sort | Tatsuya Anzai |
| collection | DOAJ |
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Intravenous immunoglobulin therapy is standard for Kawasaki disease (KD) treatment; however, anaphylactic reactions to immunoglobulins are a risk in KD patients with selective IgA deficiency (sIgAD). The therapy for KD associated with sIgAD has not been established. The IgA immune response is believed to play an important role in KD vasculitis. We report the case of a 5-year-old boy with KD and sIgAD treated with intravenous cyclosporine A (CsA, 3.0 mg/kg/day) instead of intravenous immunoglobulin (IVIG). The fever and inflammation immediately resolved without a coronary artery lesion. In KD patients with sIgAD, we believe that an IgA immune response is lacking, which is the reason for milder KD symptoms than in those without sIgAD. This case report aids in clarifying the role of IgA antibodies in KD and provides evidence that CsA is a potential candidate for first-line therapy for patients with KD with contraindications to IVIG.
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| format | Article |
| id | doaj-art-9c65e5edff7b4b00a243c569814a7d93 |
| institution | OA Journals |
| issn | 0041-4301 2791-6421 |
| language | English |
| publishDate | 2016-12-01 |
| publisher | Hacettepe University Institute of Child Health |
| record_format | Article |
| series | The Turkish Journal of Pediatrics |
| spelling | doaj-art-9c65e5edff7b4b00a243c569814a7d932025-08-20T02:01:47ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64212016-12-0158610.24953/turkjped.2016.06.015Treatment of a patient with Kawasaki disease associated with selective IgA deficiency by continuous infusion of cyclosporine A without intravenous immunoglobulinTatsuya Anzai0Takaomi Minami1Tomoyuki Sato2Sadahiro Furui3Takanori Yamagata4Department of Pediatrics, Jichi Medical University, Yakushiji, Japan.Department of Pediatrics, Jichi Medical University, Yakushiji, Japan.Department of Pediatrics, Jichi Medical University, Yakushiji, Japan.Department of Pediatrics, Jichi Medical University, Yakushiji, Japan.Department of Pediatrics, Jichi Medical University, Yakushiji, Japan. Intravenous immunoglobulin therapy is standard for Kawasaki disease (KD) treatment; however, anaphylactic reactions to immunoglobulins are a risk in KD patients with selective IgA deficiency (sIgAD). The therapy for KD associated with sIgAD has not been established. The IgA immune response is believed to play an important role in KD vasculitis. We report the case of a 5-year-old boy with KD and sIgAD treated with intravenous cyclosporine A (CsA, 3.0 mg/kg/day) instead of intravenous immunoglobulin (IVIG). The fever and inflammation immediately resolved without a coronary artery lesion. In KD patients with sIgAD, we believe that an IgA immune response is lacking, which is the reason for milder KD symptoms than in those without sIgAD. This case report aids in clarifying the role of IgA antibodies in KD and provides evidence that CsA is a potential candidate for first-line therapy for patients with KD with contraindications to IVIG. https://turkjpediatr.org/article/view/1178Kawasaki diseasecoronary artery lesioncyclosporine Aselective IgA deficiency |
| spellingShingle | Tatsuya Anzai Takaomi Minami Tomoyuki Sato Sadahiro Furui Takanori Yamagata Treatment of a patient with Kawasaki disease associated with selective IgA deficiency by continuous infusion of cyclosporine A without intravenous immunoglobulin The Turkish Journal of Pediatrics Kawasaki disease coronary artery lesion cyclosporine A selective IgA deficiency |
| title | Treatment of a patient with Kawasaki disease associated with selective IgA deficiency by continuous infusion of cyclosporine A without intravenous immunoglobulin |
| title_full | Treatment of a patient with Kawasaki disease associated with selective IgA deficiency by continuous infusion of cyclosporine A without intravenous immunoglobulin |
| title_fullStr | Treatment of a patient with Kawasaki disease associated with selective IgA deficiency by continuous infusion of cyclosporine A without intravenous immunoglobulin |
| title_full_unstemmed | Treatment of a patient with Kawasaki disease associated with selective IgA deficiency by continuous infusion of cyclosporine A without intravenous immunoglobulin |
| title_short | Treatment of a patient with Kawasaki disease associated with selective IgA deficiency by continuous infusion of cyclosporine A without intravenous immunoglobulin |
| title_sort | treatment of a patient with kawasaki disease associated with selective iga deficiency by continuous infusion of cyclosporine a without intravenous immunoglobulin |
| topic | Kawasaki disease coronary artery lesion cyclosporine A selective IgA deficiency |
| url | https://turkjpediatr.org/article/view/1178 |
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