Simple, Rapid and Sensitive UV-Visible Spectrophotometric Method for Determination of Antidepressant Amitriptyline in Pharmaceutical Dosage Forms
The paper describes a new and simple approach for spectrophotometric determination of tricyclic antidepressant drug amitriptyline. Enhancement of the colour intensity of the Fe(III)-SCN− complex on addition of the drug amitriptyline forms the basis of the proposed method. The value of molar absorpti...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Journal of Spectroscopy |
| Online Access: | http://dx.doi.org/10.1155/2013/783457 |
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| author | Pankaj Soni Deepak Sinha Rajmani Patel |
| author_facet | Pankaj Soni Deepak Sinha Rajmani Patel |
| author_sort | Pankaj Soni |
| collection | DOAJ |
| description | The paper describes a new and simple approach for spectrophotometric determination of tricyclic antidepressant drug amitriptyline. Enhancement of the colour intensity of the Fe(III)-SCN− complex on addition of the drug amitriptyline forms the basis of the proposed method. The value of molar absorptivity of the Fe(III)-SCN− amitriptyline ion pair complex in terms of the drug lies in the range of (2.82–3.36) × 103 L·mol−1·cm−1 at the absorption maximum 460 nm. The detection limit of the method was 0.3 μg·mL−1. The slope, intercept, and correlation coefficients for the present method were found to be 0.008, 0.002, and +0.998, respectively. The effect of analytical variables on the determination of the drug and the composition of the complex are discussed in the paper. The method is applicable in the determination of amitriptyline in pharmaceutical preparations. |
| format | Article |
| id | doaj-art-9c6413f4ba794c4ba487a6019ce23952 |
| institution | Kabale University |
| issn | 2314-4920 2314-4939 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Spectroscopy |
| spelling | doaj-art-9c6413f4ba794c4ba487a6019ce239522025-02-03T01:24:27ZengWileyJournal of Spectroscopy2314-49202314-49392013-01-01201310.1155/2013/783457783457Simple, Rapid and Sensitive UV-Visible Spectrophotometric Method for Determination of Antidepressant Amitriptyline in Pharmaceutical Dosage FormsPankaj Soni0Deepak Sinha1Rajmani Patel2Department of Chemistry, Government Danveer Tularam College, Utai, Durg, C.G. 490001, IndiaDepartment of Chemistry, Government Nagarjun P.G. Science College, Raipur, C.G. 492001, IndiaDepartment of Chemistry, Government College, Bhanpuri, Bastar, C.G. 494224, IndiaThe paper describes a new and simple approach for spectrophotometric determination of tricyclic antidepressant drug amitriptyline. Enhancement of the colour intensity of the Fe(III)-SCN− complex on addition of the drug amitriptyline forms the basis of the proposed method. The value of molar absorptivity of the Fe(III)-SCN− amitriptyline ion pair complex in terms of the drug lies in the range of (2.82–3.36) × 103 L·mol−1·cm−1 at the absorption maximum 460 nm. The detection limit of the method was 0.3 μg·mL−1. The slope, intercept, and correlation coefficients for the present method were found to be 0.008, 0.002, and +0.998, respectively. The effect of analytical variables on the determination of the drug and the composition of the complex are discussed in the paper. The method is applicable in the determination of amitriptyline in pharmaceutical preparations.http://dx.doi.org/10.1155/2013/783457 |
| spellingShingle | Pankaj Soni Deepak Sinha Rajmani Patel Simple, Rapid and Sensitive UV-Visible Spectrophotometric Method for Determination of Antidepressant Amitriptyline in Pharmaceutical Dosage Forms Journal of Spectroscopy |
| title | Simple, Rapid and Sensitive UV-Visible Spectrophotometric Method for Determination of Antidepressant Amitriptyline in Pharmaceutical Dosage Forms |
| title_full | Simple, Rapid and Sensitive UV-Visible Spectrophotometric Method for Determination of Antidepressant Amitriptyline in Pharmaceutical Dosage Forms |
| title_fullStr | Simple, Rapid and Sensitive UV-Visible Spectrophotometric Method for Determination of Antidepressant Amitriptyline in Pharmaceutical Dosage Forms |
| title_full_unstemmed | Simple, Rapid and Sensitive UV-Visible Spectrophotometric Method for Determination of Antidepressant Amitriptyline in Pharmaceutical Dosage Forms |
| title_short | Simple, Rapid and Sensitive UV-Visible Spectrophotometric Method for Determination of Antidepressant Amitriptyline in Pharmaceutical Dosage Forms |
| title_sort | simple rapid and sensitive uv visible spectrophotometric method for determination of antidepressant amitriptyline in pharmaceutical dosage forms |
| url | http://dx.doi.org/10.1155/2013/783457 |
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