The Anti-Inflammatory Effect of Chenopodium Murale in Comparison to Salvia Frigida on Atopic Eczema
Background: Atopic dermatitis (AD) is a prevalent chronic inflammatory skin condition with a familial tendency. It affects approximately 10%-20% of children and 1%-3% of adults worldwide. Chenopodium murale is clinically proven for treating many medical conditions, such as AD, due to its easy appli...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
College of Medicine University of Baghdad
2024-12-01
|
| Series: | مجلة كلية الطب |
| Subjects: | |
| Online Access: | https://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/2371 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832594709121335296 |
|---|---|
| author | Zahraa Y. Hassan Tuka Y. Hassan Ahmed Y. Kanany |
| author_facet | Zahraa Y. Hassan Tuka Y. Hassan Ahmed Y. Kanany |
| author_sort | Zahraa Y. Hassan |
| collection | DOAJ |
| description |
Background: Atopic dermatitis (AD) is a prevalent chronic inflammatory skin condition with a familial tendency. It affects approximately 10%-20% of children and 1%-3% of adults worldwide. Chenopodium murale is clinically proven for treating many medical conditions, such as AD, due to its easy application and efficacy. Salvia plant has an anti-inflammatory effect on AD cases treated with phenolic compounds.
Objective: To determine the anti-inflammatory effect of the phytosterol fraction of Chenopodium murale (CM) in comparison to Salvia frigida (SF).
Methods: This study was conducted from December 2020 to June 2021 in the Department of Pharmacology, College of Medicine, Al Nahrain University. Fifty mice were included in the study, subdivided equally into five subgroups [control, induction, Tacrolimus-1%, Phytosterol-3%, and Phenolic-5%]. Biological and histological parameters were measured, and their means were compared using the independent t-test, and the one-way ANOVA was used to estimate the mean of differences.
Results: The Tacrolimus-1% group showed a significant decrease in white blood cells, Ig-E, and inflammation means than other groups; a significant decrease in mean epidermal thickness than the Phytosterol-3% groups; and a significant decrease in IL-13 and erosion than the Phenolic-5% groups. The phytosterol-3% group showed a significant decrease in the mean parakeratosis, erosion, and observational severity (OS) score than other groups. The phenolic-5% group showed a significant decrease in the mean epidermal thickness than other groups and a significant decrease in OS score than the Tacrolimus-1% groups.
Conclusion: The topical applications of the phytosterol fraction of Chenopodium murale or the phenolic compound of Salvia frigida were effective and promising in treating atopic dermatitis. While the phenolic compound of Salvia frigida is effective, it is somewhat less than that of the phytosterol fraction of Chenopodium murale.
|
| format | Article |
| id | doaj-art-9c494335175540e6aed682023bd3fc6e |
| institution | Kabale University |
| issn | 0041-9419 2410-8057 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | College of Medicine University of Baghdad |
| record_format | Article |
| series | مجلة كلية الطب |
| spelling | doaj-art-9c494335175540e6aed682023bd3fc6e2025-01-19T12:24:10ZengCollege of Medicine University of Baghdadمجلة كلية الطب0041-94192410-80572024-12-0166410.32007/jfacmedbaghdad.6642371The Anti-Inflammatory Effect of Chenopodium Murale in Comparison to Salvia Frigida on Atopic EczemaZahraa Y. Hassan0https://orcid.org/0009-0005-5071-7899Tuka Y. Hassan1https://orcid.org/0000-0003-4573-8335Ahmed Y. Kanany 2https://orcid.org/0009-0008-2792-172XAl-Imamain Al-Kadhimain Medical city, Al-Karkh Health Directorate, Ministry Of Health, Baghdad-Iraq.Public Health Directorate, MOH, Baghdad, Iraq.University of California, San Diego, CA, USA. Background: Atopic dermatitis (AD) is a prevalent chronic inflammatory skin condition with a familial tendency. It affects approximately 10%-20% of children and 1%-3% of adults worldwide. Chenopodium murale is clinically proven for treating many medical conditions, such as AD, due to its easy application and efficacy. Salvia plant has an anti-inflammatory effect on AD cases treated with phenolic compounds. Objective: To determine the anti-inflammatory effect of the phytosterol fraction of Chenopodium murale (CM) in comparison to Salvia frigida (SF). Methods: This study was conducted from December 2020 to June 2021 in the Department of Pharmacology, College of Medicine, Al Nahrain University. Fifty mice were included in the study, subdivided equally into five subgroups [control, induction, Tacrolimus-1%, Phytosterol-3%, and Phenolic-5%]. Biological and histological parameters were measured, and their means were compared using the independent t-test, and the one-way ANOVA was used to estimate the mean of differences. Results: The Tacrolimus-1% group showed a significant decrease in white blood cells, Ig-E, and inflammation means than other groups; a significant decrease in mean epidermal thickness than the Phytosterol-3% groups; and a significant decrease in IL-13 and erosion than the Phenolic-5% groups. The phytosterol-3% group showed a significant decrease in the mean parakeratosis, erosion, and observational severity (OS) score than other groups. The phenolic-5% group showed a significant decrease in the mean epidermal thickness than other groups and a significant decrease in OS score than the Tacrolimus-1% groups. Conclusion: The topical applications of the phytosterol fraction of Chenopodium murale or the phenolic compound of Salvia frigida were effective and promising in treating atopic dermatitis. While the phenolic compound of Salvia frigida is effective, it is somewhat less than that of the phytosterol fraction of Chenopodium murale. https://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/2371Atopic dermatitisChenopodium muralePhenolic compoundSalvia frigidaTacrolimus |
| spellingShingle | Zahraa Y. Hassan Tuka Y. Hassan Ahmed Y. Kanany The Anti-Inflammatory Effect of Chenopodium Murale in Comparison to Salvia Frigida on Atopic Eczema مجلة كلية الطب Atopic dermatitis Chenopodium murale Phenolic compound Salvia frigida Tacrolimus |
| title | The Anti-Inflammatory Effect of Chenopodium Murale in Comparison to Salvia Frigida on Atopic Eczema |
| title_full | The Anti-Inflammatory Effect of Chenopodium Murale in Comparison to Salvia Frigida on Atopic Eczema |
| title_fullStr | The Anti-Inflammatory Effect of Chenopodium Murale in Comparison to Salvia Frigida on Atopic Eczema |
| title_full_unstemmed | The Anti-Inflammatory Effect of Chenopodium Murale in Comparison to Salvia Frigida on Atopic Eczema |
| title_short | The Anti-Inflammatory Effect of Chenopodium Murale in Comparison to Salvia Frigida on Atopic Eczema |
| title_sort | anti inflammatory effect of chenopodium murale in comparison to salvia frigida on atopic eczema |
| topic | Atopic dermatitis Chenopodium murale Phenolic compound Salvia frigida Tacrolimus |
| url | https://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/2371 |
| work_keys_str_mv | AT zahraayhassan theantiinflammatoryeffectofchenopodiummuraleincomparisontosalviafrigidaonatopiceczema AT tukayhassan theantiinflammatoryeffectofchenopodiummuraleincomparisontosalviafrigidaonatopiceczema AT ahmedykanany theantiinflammatoryeffectofchenopodiummuraleincomparisontosalviafrigidaonatopiceczema AT zahraayhassan antiinflammatoryeffectofchenopodiummuraleincomparisontosalviafrigidaonatopiceczema AT tukayhassan antiinflammatoryeffectofchenopodiummuraleincomparisontosalviafrigidaonatopiceczema AT ahmedykanany antiinflammatoryeffectofchenopodiummuraleincomparisontosalviafrigidaonatopiceczema |