The Role of Monocyte/Macrophage and CXCR3 in Differentiation between Recurrent Hepatitis C and Acute Cellular Rejection Postliver Transplantation
Objective. Liver transplantation (LT) is the recommended treatment for patients with advanced liver disease and cirrhosis in all guidelines, mostly as a complication of HCV. The distinction between reinfection of the graft with HCV and acute cellular rejection (ACR) is essential because they are man...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2018/2726939 |
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| author | Asmaa Ibrahim Gomaa Nermine Ahmed Ehsan Ahmed A. Elrefaei Mervat Mohamed Sultan Maha Mohamed Elsabaawy |
| author_facet | Asmaa Ibrahim Gomaa Nermine Ahmed Ehsan Ahmed A. Elrefaei Mervat Mohamed Sultan Maha Mohamed Elsabaawy |
| author_sort | Asmaa Ibrahim Gomaa |
| collection | DOAJ |
| description | Objective. Liver transplantation (LT) is the recommended treatment for patients with advanced liver disease and cirrhosis in all guidelines, mostly as a complication of HCV. The distinction between reinfection of the graft with HCV and acute cellular rejection (ACR) is essential because they are managed differently. Hepatic macrophages, which can either arise from circulating blood-derived monocytes (BDM) or from resident tissue Kupffer cells, are central in the pathogenesis of chronic liver injury. The aim of this work was to evaluate whether the origin of macrophages and the immune mediator CXCR3 could help in differentiating between acute recurrent HCV and ACR after liver transplantation. Methods. Twenty-nine cases of recurrent hepatitis C and 26 cases of ACR were included in this study. The expression of CD 68 (macrophage marker), CD11b (BDM marker), and CxCR3 in the postliver transplant biopsy using immunohistochemistry was determined. Results. CD11b expression highlighting macrophages of BDM origin was in favor of recurrent hepatitis C (P<0.001) than in ACR (P=0.44), while CXCR3 expression by hepatocytes was in favor of ACR (P=0.001). Conclusion. Macrophage infiltrating liver tissue post LT can distinguish between ACR by upregulation of CXCR3 and recurrent hepatitis C by predominant CD11b. |
| format | Article |
| id | doaj-art-9c46f05c81b44ffe878f7e52870275cd |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-9c46f05c81b44ffe878f7e52870275cd2025-02-03T06:11:29ZengWileyJournal of Immunology Research2314-88612314-71562018-01-01201810.1155/2018/27269392726939The Role of Monocyte/Macrophage and CXCR3 in Differentiation between Recurrent Hepatitis C and Acute Cellular Rejection Postliver TransplantationAsmaa Ibrahim Gomaa0Nermine Ahmed Ehsan1Ahmed A. Elrefaei2Mervat Mohamed Sultan3Maha Mohamed Elsabaawy4Department of Hepatology and Gastroenterology, National Liver Institute, Menoufia University, Shebin El Koum, EgyptDepartment of Pathology, National Liver Institute, Menoufia University, Shebin El Koum, EgyptDepartment of Pathology, National Liver Institute, Menoufia University, Shebin El Koum, EgyptDepartment of Pathology, National Liver Institute, Menoufia University, Shebin El Koum, EgyptDepartment of Hepatology and Gastroenterology, National Liver Institute, Menoufia University, Shebin El Koum, EgyptObjective. Liver transplantation (LT) is the recommended treatment for patients with advanced liver disease and cirrhosis in all guidelines, mostly as a complication of HCV. The distinction between reinfection of the graft with HCV and acute cellular rejection (ACR) is essential because they are managed differently. Hepatic macrophages, which can either arise from circulating blood-derived monocytes (BDM) or from resident tissue Kupffer cells, are central in the pathogenesis of chronic liver injury. The aim of this work was to evaluate whether the origin of macrophages and the immune mediator CXCR3 could help in differentiating between acute recurrent HCV and ACR after liver transplantation. Methods. Twenty-nine cases of recurrent hepatitis C and 26 cases of ACR were included in this study. The expression of CD 68 (macrophage marker), CD11b (BDM marker), and CxCR3 in the postliver transplant biopsy using immunohistochemistry was determined. Results. CD11b expression highlighting macrophages of BDM origin was in favor of recurrent hepatitis C (P<0.001) than in ACR (P=0.44), while CXCR3 expression by hepatocytes was in favor of ACR (P=0.001). Conclusion. Macrophage infiltrating liver tissue post LT can distinguish between ACR by upregulation of CXCR3 and recurrent hepatitis C by predominant CD11b.http://dx.doi.org/10.1155/2018/2726939 |
| spellingShingle | Asmaa Ibrahim Gomaa Nermine Ahmed Ehsan Ahmed A. Elrefaei Mervat Mohamed Sultan Maha Mohamed Elsabaawy The Role of Monocyte/Macrophage and CXCR3 in Differentiation between Recurrent Hepatitis C and Acute Cellular Rejection Postliver Transplantation Journal of Immunology Research |
| title | The Role of Monocyte/Macrophage and CXCR3 in Differentiation between Recurrent Hepatitis C and Acute Cellular Rejection Postliver Transplantation |
| title_full | The Role of Monocyte/Macrophage and CXCR3 in Differentiation between Recurrent Hepatitis C and Acute Cellular Rejection Postliver Transplantation |
| title_fullStr | The Role of Monocyte/Macrophage and CXCR3 in Differentiation between Recurrent Hepatitis C and Acute Cellular Rejection Postliver Transplantation |
| title_full_unstemmed | The Role of Monocyte/Macrophage and CXCR3 in Differentiation between Recurrent Hepatitis C and Acute Cellular Rejection Postliver Transplantation |
| title_short | The Role of Monocyte/Macrophage and CXCR3 in Differentiation between Recurrent Hepatitis C and Acute Cellular Rejection Postliver Transplantation |
| title_sort | role of monocyte macrophage and cxcr3 in differentiation between recurrent hepatitis c and acute cellular rejection postliver transplantation |
| url | http://dx.doi.org/10.1155/2018/2726939 |
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