Application of Light-Responsive Nanomaterials in Bone Tissue Engineering
The application of light-responsive nanomaterials (LRNs) in bone tissue engineering shows broad prospects, especially in promoting bone healing and regeneration. With a deeper understanding of the mechanisms of bone defects and healing disorders, LRNs are receiving increasing attention due to their...
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2025-01-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/17/1/98 |
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| author | Aiguo Liu Chenxu Wang Shuang Deng Sitong Zhang Ziwen Zhao Han Xiao Ting Ying Chengqing Yi Dejian Li |
| author_facet | Aiguo Liu Chenxu Wang Shuang Deng Sitong Zhang Ziwen Zhao Han Xiao Ting Ying Chengqing Yi Dejian Li |
| author_sort | Aiguo Liu |
| collection | DOAJ |
| description | The application of light-responsive nanomaterials (LRNs) in bone tissue engineering shows broad prospects, especially in promoting bone healing and regeneration. With a deeper understanding of the mechanisms of bone defects and healing disorders, LRNs are receiving increasing attention due to their non-invasive, controllable, and efficient properties. These materials can regulate cellular biological reactions and promote bone cell adhesion, proliferation, and differentiation by absorbing specific wavelengths of light and converting them into physical and chemical signals. In addition, the unique surface morphology and biocompatibility of LRNs enable them to effectively load drugs in bone tissue engineering, achieve precise release, and optimize the bone regeneration process. Through photothermal and photodynamic therapy, these materials also possess antibacterial properties and can play an important role in the repair of infectious bone defects. Although LRNs have shown significant advantages in bone tissue regeneration, a series of challenges still need to be overcome to achieve their widespread and effective clinical applications. This article summarizes the basic principles, classification, and potential applications of LRNs in bone tissue regeneration, aiming to provide reference for future research and clinical applications. |
| format | Article |
| id | doaj-art-9c3f45a483384ebb85b1442d224635a2 |
| institution | Kabale University |
| issn | 1999-4923 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj-art-9c3f45a483384ebb85b1442d224635a22025-01-24T13:45:57ZengMDPI AGPharmaceutics1999-49232025-01-011719810.3390/pharmaceutics17010098Application of Light-Responsive Nanomaterials in Bone Tissue EngineeringAiguo Liu0Chenxu Wang1Shuang Deng2Sitong Zhang3Ziwen Zhao4Han Xiao5Ting Ying6Chengqing Yi7Dejian Li8Department of Orthopedics, The First Affiliated Hospital of Henan University, Kaifeng 475000, ChinaDepartment of Orthopedics, The First Affiliated Hospital of Henan University, Kaifeng 475000, ChinaDepartment of Orthopedics, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, 2800 Gongwei Road, Pudong, Shanghai 201300, ChinaDepartment of Orthopedics, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, 2800 Gongwei Road, Pudong, Shanghai 201300, ChinaDepartment of Orthopedics, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, 2800 Gongwei Road, Pudong, Shanghai 201300, ChinaDepartment of Orthopedics, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, 2800 Gongwei Road, Pudong, Shanghai 201300, ChinaDepartment of Orthopedics, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, 2800 Gongwei Road, Pudong, Shanghai 201300, ChinaDepartment of Orthopedics, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, 2800 Gongwei Road, Pudong, Shanghai 201300, ChinaDepartment of Orthopedics, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, 2800 Gongwei Road, Pudong, Shanghai 201300, ChinaThe application of light-responsive nanomaterials (LRNs) in bone tissue engineering shows broad prospects, especially in promoting bone healing and regeneration. With a deeper understanding of the mechanisms of bone defects and healing disorders, LRNs are receiving increasing attention due to their non-invasive, controllable, and efficient properties. These materials can regulate cellular biological reactions and promote bone cell adhesion, proliferation, and differentiation by absorbing specific wavelengths of light and converting them into physical and chemical signals. In addition, the unique surface morphology and biocompatibility of LRNs enable them to effectively load drugs in bone tissue engineering, achieve precise release, and optimize the bone regeneration process. Through photothermal and photodynamic therapy, these materials also possess antibacterial properties and can play an important role in the repair of infectious bone defects. Although LRNs have shown significant advantages in bone tissue regeneration, a series of challenges still need to be overcome to achieve their widespread and effective clinical applications. This article summarizes the basic principles, classification, and potential applications of LRNs in bone tissue regeneration, aiming to provide reference for future research and clinical applications.https://www.mdpi.com/1999-4923/17/1/98photoresponsivenanometer materialbone regenerationphotothermal therapyphotodynamic therapy |
| spellingShingle | Aiguo Liu Chenxu Wang Shuang Deng Sitong Zhang Ziwen Zhao Han Xiao Ting Ying Chengqing Yi Dejian Li Application of Light-Responsive Nanomaterials in Bone Tissue Engineering Pharmaceutics photoresponsive nanometer material bone regeneration photothermal therapy photodynamic therapy |
| title | Application of Light-Responsive Nanomaterials in Bone Tissue Engineering |
| title_full | Application of Light-Responsive Nanomaterials in Bone Tissue Engineering |
| title_fullStr | Application of Light-Responsive Nanomaterials in Bone Tissue Engineering |
| title_full_unstemmed | Application of Light-Responsive Nanomaterials in Bone Tissue Engineering |
| title_short | Application of Light-Responsive Nanomaterials in Bone Tissue Engineering |
| title_sort | application of light responsive nanomaterials in bone tissue engineering |
| topic | photoresponsive nanometer material bone regeneration photothermal therapy photodynamic therapy |
| url | https://www.mdpi.com/1999-4923/17/1/98 |
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