Expansion of Circulating T Follicular Helper Cells in Children with Acute Henoch-Schönlein Purpura
Henoch-Schönlein purpura (HSP) is a common systemic small vessel vasculitis in children with disorder autoimmune responses. T follicular helper (TFH) cells play crucial roles in regulating immune responses. The aim of our study was to investigate the probable role of TFH cells in the pathogenesis of...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2015/742535 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832548414890442752 |
|---|---|
| author | Jue Xie Yan Liu Lei Wang Guoxiang Ruan Huiming Yuan Hong Fang Jianyong Wu Dawei Cui |
| author_facet | Jue Xie Yan Liu Lei Wang Guoxiang Ruan Huiming Yuan Hong Fang Jianyong Wu Dawei Cui |
| author_sort | Jue Xie |
| collection | DOAJ |
| description | Henoch-Schönlein purpura (HSP) is a common systemic small vessel vasculitis in children with disorder autoimmune responses. T follicular helper (TFH) cells play crucial roles in regulating immune responses. The aim of our study was to investigate the probable role of TFH cells in the pathogenesis of children with HSP. In this study, the frequency of circulating CXCR5+CD4+TFH cells with inducible costimulator (ICOS) expression in the children with acute HSP was significantly higher than that in healthy controls (HCs) but not CXCR5+CD4+TFH cells with programmed death-1 (PD-1) expression. Moreover, serum levels of IL-21 and IL-6 cytokines, IgA, and C3 in HSP children were also significantly higher than those in HCs. A positive correlation was observed between the frequencies of circulating ICOS+CXCR5+CD4+TFH cells and the serum IL-21 or IgA levels of acute HSP children, respectively. Additionally, the mRNA expression levels of interleukin- (IL-) 21, IL-6, and transcriptional factors (B-cell lymphoma-6, Bcl-6) were also significantly increased in peripheral blood from acute HSP children compared to HCs. Taken together, these findings suggest that TFH cells and associated molecules might play critical roles in the pathogenesis of HSP, which are possible therapeutic targets in HSP children. |
| format | Article |
| id | doaj-art-9c3a337bb5c04dd3ac340fad54b9a49a |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-9c3a337bb5c04dd3ac340fad54b9a49a2025-02-03T06:14:09ZengWileyJournal of Immunology Research2314-88612314-71562015-01-01201510.1155/2015/742535742535Expansion of Circulating T Follicular Helper Cells in Children with Acute Henoch-Schönlein PurpuraJue Xie0Yan Liu1Lei Wang2Guoxiang Ruan3Huiming Yuan4Hong Fang5Jianyong Wu6Dawei Cui7Department of Blood Transfusion, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, ChinaDepartment of Blood Transfusion, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, ChinaDepartment of Blood Transfusion, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, ChinaDepartment of Blood Transfusion, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, ChinaDepartment of Blood Transfusion, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, ChinaDepartment of Dermatology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, ChinaKidney Disease Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, ChinaDepartment of Clinical Laboratory, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, ChinaHenoch-Schönlein purpura (HSP) is a common systemic small vessel vasculitis in children with disorder autoimmune responses. T follicular helper (TFH) cells play crucial roles in regulating immune responses. The aim of our study was to investigate the probable role of TFH cells in the pathogenesis of children with HSP. In this study, the frequency of circulating CXCR5+CD4+TFH cells with inducible costimulator (ICOS) expression in the children with acute HSP was significantly higher than that in healthy controls (HCs) but not CXCR5+CD4+TFH cells with programmed death-1 (PD-1) expression. Moreover, serum levels of IL-21 and IL-6 cytokines, IgA, and C3 in HSP children were also significantly higher than those in HCs. A positive correlation was observed between the frequencies of circulating ICOS+CXCR5+CD4+TFH cells and the serum IL-21 or IgA levels of acute HSP children, respectively. Additionally, the mRNA expression levels of interleukin- (IL-) 21, IL-6, and transcriptional factors (B-cell lymphoma-6, Bcl-6) were also significantly increased in peripheral blood from acute HSP children compared to HCs. Taken together, these findings suggest that TFH cells and associated molecules might play critical roles in the pathogenesis of HSP, which are possible therapeutic targets in HSP children.http://dx.doi.org/10.1155/2015/742535 |
| spellingShingle | Jue Xie Yan Liu Lei Wang Guoxiang Ruan Huiming Yuan Hong Fang Jianyong Wu Dawei Cui Expansion of Circulating T Follicular Helper Cells in Children with Acute Henoch-Schönlein Purpura Journal of Immunology Research |
| title | Expansion of Circulating T Follicular Helper Cells in Children with Acute Henoch-Schönlein Purpura |
| title_full | Expansion of Circulating T Follicular Helper Cells in Children with Acute Henoch-Schönlein Purpura |
| title_fullStr | Expansion of Circulating T Follicular Helper Cells in Children with Acute Henoch-Schönlein Purpura |
| title_full_unstemmed | Expansion of Circulating T Follicular Helper Cells in Children with Acute Henoch-Schönlein Purpura |
| title_short | Expansion of Circulating T Follicular Helper Cells in Children with Acute Henoch-Schönlein Purpura |
| title_sort | expansion of circulating t follicular helper cells in children with acute henoch schonlein purpura |
| url | http://dx.doi.org/10.1155/2015/742535 |
| work_keys_str_mv | AT juexie expansionofcirculatingtfollicularhelpercellsinchildrenwithacutehenochschonleinpurpura AT yanliu expansionofcirculatingtfollicularhelpercellsinchildrenwithacutehenochschonleinpurpura AT leiwang expansionofcirculatingtfollicularhelpercellsinchildrenwithacutehenochschonleinpurpura AT guoxiangruan expansionofcirculatingtfollicularhelpercellsinchildrenwithacutehenochschonleinpurpura AT huimingyuan expansionofcirculatingtfollicularhelpercellsinchildrenwithacutehenochschonleinpurpura AT hongfang expansionofcirculatingtfollicularhelpercellsinchildrenwithacutehenochschonleinpurpura AT jianyongwu expansionofcirculatingtfollicularhelpercellsinchildrenwithacutehenochschonleinpurpura AT daweicui expansionofcirculatingtfollicularhelpercellsinchildrenwithacutehenochschonleinpurpura |