Successfully Treated Calcific Uremic Arteriolopathy: Two Cases of a High Anion Gap Metabolic Acidosis with Intravenous Sodium Thiosulfate
Calcific uremic arteriolopathy (CUA) is a rare and potentially fatal disorder of calcification involving subcutaneous small vessels and fat in patients with renal insufficiency. We describe the successful use of intravenous sodium thiosulfate (STS) for the treatment of CUA in two patients. The first...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Case Reports in Nephrology |
| Online Access: | http://dx.doi.org/10.1155/2014/765134 |
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| author | Joshua L. Rein Kana N. Miyata Kobena A. Dadzie Steven J. Gruber Roxana Sulica James F. Winchester |
| author_facet | Joshua L. Rein Kana N. Miyata Kobena A. Dadzie Steven J. Gruber Roxana Sulica James F. Winchester |
| author_sort | Joshua L. Rein |
| collection | DOAJ |
| description | Calcific uremic arteriolopathy (CUA) is a rare and potentially fatal disorder of calcification involving subcutaneous small vessels and fat in patients with renal insufficiency. We describe the successful use of intravenous sodium thiosulfate (STS) for the treatment of CUA in two patients. The first case was complicated by the development of a severe anion gap metabolic acidosis, which was accompanied by a seizure. Both patients had complete wound healing within five months. Although STS should be considered in the treatment of CUA, little is known about pharmacokinetics and additional studies are required to determine dosing strategies to minimize severe potential side effects. |
| format | Article |
| id | doaj-art-9c332fd4a1364589890ca1eb2523c1f6 |
| institution | Kabale University |
| issn | 2090-6641 2090-665X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Nephrology |
| spelling | doaj-art-9c332fd4a1364589890ca1eb2523c1f62025-02-03T06:44:44ZengWileyCase Reports in Nephrology2090-66412090-665X2014-01-01201410.1155/2014/765134765134Successfully Treated Calcific Uremic Arteriolopathy: Two Cases of a High Anion Gap Metabolic Acidosis with Intravenous Sodium ThiosulfateJoshua L. Rein0Kana N. Miyata1Kobena A. Dadzie2Steven J. Gruber3Roxana Sulica4James F. Winchester5Department of Medicine, Mount Sinai Beth Israel, 350 E 17th Street, 20th Floor Baird Hall, New York, NY 10003, USADepartment of Medicine, Mount Sinai Beth Israel, 350 E 17th Street, 20th Floor Baird Hall, New York, NY 10003, USADivision of Nephrology and Hypertension, Mount Sinai Beth Israel, 350 E 17th Street, 18th Floor Baird Hall, New York, NY 10003, USADivision of Nephrology and Hypertension, Mount Sinai Beth Israel, 350 E 17th Street, 18th Floor Baird Hall, New York, NY 10003, USADepartment of Pulmonary, Critical Care & Sleep Medicine, Mount Sinai Beth Israel, 7 Dazian Building, 1st Avenue at 16th Street, New York, NY 10003, USADivision of Nephrology and Hypertension, Mount Sinai Beth Israel, 350 E 17th Street, 18th Floor Baird Hall, New York, NY 10003, USACalcific uremic arteriolopathy (CUA) is a rare and potentially fatal disorder of calcification involving subcutaneous small vessels and fat in patients with renal insufficiency. We describe the successful use of intravenous sodium thiosulfate (STS) for the treatment of CUA in two patients. The first case was complicated by the development of a severe anion gap metabolic acidosis, which was accompanied by a seizure. Both patients had complete wound healing within five months. Although STS should be considered in the treatment of CUA, little is known about pharmacokinetics and additional studies are required to determine dosing strategies to minimize severe potential side effects.http://dx.doi.org/10.1155/2014/765134 |
| spellingShingle | Joshua L. Rein Kana N. Miyata Kobena A. Dadzie Steven J. Gruber Roxana Sulica James F. Winchester Successfully Treated Calcific Uremic Arteriolopathy: Two Cases of a High Anion Gap Metabolic Acidosis with Intravenous Sodium Thiosulfate Case Reports in Nephrology |
| title | Successfully Treated Calcific Uremic Arteriolopathy: Two Cases of a High Anion Gap Metabolic Acidosis with Intravenous Sodium Thiosulfate |
| title_full | Successfully Treated Calcific Uremic Arteriolopathy: Two Cases of a High Anion Gap Metabolic Acidosis with Intravenous Sodium Thiosulfate |
| title_fullStr | Successfully Treated Calcific Uremic Arteriolopathy: Two Cases of a High Anion Gap Metabolic Acidosis with Intravenous Sodium Thiosulfate |
| title_full_unstemmed | Successfully Treated Calcific Uremic Arteriolopathy: Two Cases of a High Anion Gap Metabolic Acidosis with Intravenous Sodium Thiosulfate |
| title_short | Successfully Treated Calcific Uremic Arteriolopathy: Two Cases of a High Anion Gap Metabolic Acidosis with Intravenous Sodium Thiosulfate |
| title_sort | successfully treated calcific uremic arteriolopathy two cases of a high anion gap metabolic acidosis with intravenous sodium thiosulfate |
| url | http://dx.doi.org/10.1155/2014/765134 |
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