A Meta-Analysis on the Relations between EGFR R521K Polymorphism and Risk of Cancer
The EGFR R521K polymorphism has been shown to reduce the activity of EGFR; however, the association between EGFR R521K polymorphism and the risk of cancer remains inconclusive; therefore we performed a meta-analysis to evaluate the relationship between EGFR R521K polymorphism and susceptibility to c...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2014-01-01
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| Series: | International Journal of Genomics |
| Online Access: | http://dx.doi.org/10.1155/2014/312102 |
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| _version_ | 1832552997669830656 |
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| author | Yinsheng Wang Lidan Zha Dan Liao Xiaozhi Li |
| author_facet | Yinsheng Wang Lidan Zha Dan Liao Xiaozhi Li |
| author_sort | Yinsheng Wang |
| collection | DOAJ |
| description | The EGFR R521K polymorphism has been shown to reduce the activity of EGFR; however, the association between EGFR R521K polymorphism and the risk of cancer remains inconclusive; therefore we performed a meta-analysis to evaluate the relationship between EGFR R521K polymorphism and susceptibility to cancer. Our results suggest that the EGFR R521K polymorphism is not associated with risk of cancer, but the different chemosensitivity to anticancer drugs may need further investigation. |
| format | Article |
| id | doaj-art-9c0981197bf146efaa8d515a94265c39 |
| institution | Kabale University |
| issn | 2314-436X 2314-4378 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Genomics |
| spelling | doaj-art-9c0981197bf146efaa8d515a94265c392025-02-03T05:57:12ZengWileyInternational Journal of Genomics2314-436X2314-43782014-01-01201410.1155/2014/312102312102A Meta-Analysis on the Relations between EGFR R521K Polymorphism and Risk of CancerYinsheng Wang0Lidan Zha1Dan Liao2Xiaozhi Li3Department of Stomatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, No. 1 Yixueyuan Road, Chongqing 400016, ChinaDepartment of Stomatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, No. 1 Yixueyuan Road, Chongqing 400016, ChinaDepartment of Stomatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, No. 1 Yixueyuan Road, Chongqing 400016, ChinaDepartment of Stomatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, No. 1 Yixueyuan Road, Chongqing 400016, ChinaThe EGFR R521K polymorphism has been shown to reduce the activity of EGFR; however, the association between EGFR R521K polymorphism and the risk of cancer remains inconclusive; therefore we performed a meta-analysis to evaluate the relationship between EGFR R521K polymorphism and susceptibility to cancer. Our results suggest that the EGFR R521K polymorphism is not associated with risk of cancer, but the different chemosensitivity to anticancer drugs may need further investigation.http://dx.doi.org/10.1155/2014/312102 |
| spellingShingle | Yinsheng Wang Lidan Zha Dan Liao Xiaozhi Li A Meta-Analysis on the Relations between EGFR R521K Polymorphism and Risk of Cancer International Journal of Genomics |
| title | A Meta-Analysis on the Relations between EGFR R521K Polymorphism and Risk of Cancer |
| title_full | A Meta-Analysis on the Relations between EGFR R521K Polymorphism and Risk of Cancer |
| title_fullStr | A Meta-Analysis on the Relations between EGFR R521K Polymorphism and Risk of Cancer |
| title_full_unstemmed | A Meta-Analysis on the Relations between EGFR R521K Polymorphism and Risk of Cancer |
| title_short | A Meta-Analysis on the Relations between EGFR R521K Polymorphism and Risk of Cancer |
| title_sort | meta analysis on the relations between egfr r521k polymorphism and risk of cancer |
| url | http://dx.doi.org/10.1155/2014/312102 |
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