A Practical Catalyst-Free Synthesis of 6-Amino-4 Alkyl/Aryl-3-methyl-2,4-dihydropyrano[2,3-c]pyrazole-carbonitrile in Aqueous Medium
A completely green and improved method for the synthesis of 6-amino-4-aryl-3-methyl-2,4-dihydropyrano[2,3-c]pyrazole-carbonitriles by a four-component reaction of a mixture of ethyl acetoacetate, hydrazine hydrate, aldehyde, and malononitrile in boiling water is reported. Similar synthesis starting...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2013/920719 |
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| author | Manisha Bihani Pranjal P. Bora Ghanashyam Bez |
| author_facet | Manisha Bihani Pranjal P. Bora Ghanashyam Bez |
| author_sort | Manisha Bihani |
| collection | DOAJ |
| description | A completely green and improved method for the synthesis of 6-amino-4-aryl-3-methyl-2,4-dihydropyrano[2,3-c]pyrazole-carbonitriles by a four-component reaction of a mixture of ethyl acetoacetate, hydrazine hydrate, aldehyde, and malononitrile in boiling water is reported. Similar synthesis starting from aliphatic aldehydes was carried out in water: ethanol (1 : 1) at reflux temperature without using any catalyst. |
| format | Article |
| id | doaj-art-9c03101a362746118dae53e433b516bd |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-9c03101a362746118dae53e433b516bd2025-02-03T07:24:28ZengWileyJournal of Chemistry2090-90632090-90712013-01-01201310.1155/2013/920719920719A Practical Catalyst-Free Synthesis of 6-Amino-4 Alkyl/Aryl-3-methyl-2,4-dihydropyrano[2,3-c]pyrazole-carbonitrile in Aqueous MediumManisha Bihani0Pranjal P. Bora1Ghanashyam Bez2Department of Chemistry, North Eastern Hill University, Shillong 793022, IndiaDepartment of Chemistry, North Eastern Hill University, Shillong 793022, IndiaDepartment of Chemistry, North Eastern Hill University, Shillong 793022, IndiaA completely green and improved method for the synthesis of 6-amino-4-aryl-3-methyl-2,4-dihydropyrano[2,3-c]pyrazole-carbonitriles by a four-component reaction of a mixture of ethyl acetoacetate, hydrazine hydrate, aldehyde, and malononitrile in boiling water is reported. Similar synthesis starting from aliphatic aldehydes was carried out in water: ethanol (1 : 1) at reflux temperature without using any catalyst.http://dx.doi.org/10.1155/2013/920719 |
| spellingShingle | Manisha Bihani Pranjal P. Bora Ghanashyam Bez A Practical Catalyst-Free Synthesis of 6-Amino-4 Alkyl/Aryl-3-methyl-2,4-dihydropyrano[2,3-c]pyrazole-carbonitrile in Aqueous Medium Journal of Chemistry |
| title | A Practical Catalyst-Free Synthesis of 6-Amino-4 Alkyl/Aryl-3-methyl-2,4-dihydropyrano[2,3-c]pyrazole-carbonitrile in Aqueous Medium |
| title_full | A Practical Catalyst-Free Synthesis of 6-Amino-4 Alkyl/Aryl-3-methyl-2,4-dihydropyrano[2,3-c]pyrazole-carbonitrile in Aqueous Medium |
| title_fullStr | A Practical Catalyst-Free Synthesis of 6-Amino-4 Alkyl/Aryl-3-methyl-2,4-dihydropyrano[2,3-c]pyrazole-carbonitrile in Aqueous Medium |
| title_full_unstemmed | A Practical Catalyst-Free Synthesis of 6-Amino-4 Alkyl/Aryl-3-methyl-2,4-dihydropyrano[2,3-c]pyrazole-carbonitrile in Aqueous Medium |
| title_short | A Practical Catalyst-Free Synthesis of 6-Amino-4 Alkyl/Aryl-3-methyl-2,4-dihydropyrano[2,3-c]pyrazole-carbonitrile in Aqueous Medium |
| title_sort | practical catalyst free synthesis of 6 amino 4 alkyl aryl 3 methyl 2 4 dihydropyrano 2 3 c pyrazole carbonitrile in aqueous medium |
| url | http://dx.doi.org/10.1155/2013/920719 |
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