Study of Single Nucleotide Polymorphisms Associated with Breast Cancer Patients among Arab Ancestries
The aim of this study is to investigate the single nucleotide polymorphisms (SNPs) associated with breast cancer in our population of Arab patients. We investigated 26 breast cancer patients and an equal number of healthy age- and sex-matched control volunteers. We examined the exome wide microarray...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | International Journal of Breast Cancer |
| Online Access: | http://dx.doi.org/10.1155/2022/2442109 |
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| author | Yasser Osman Tarek Elsharkawy Tariq Mohammad Hashim Jumana Abdulwahab Alratroot Fatima Aljindan Liqa Almulla Hind Saleh Alsuwat Waad Mohammed Al Otaibi Fatma Mohammed Hegazi Abdallah M. Ibrahim J. Francis Borgio Sayed AbdulAzeez |
| author_facet | Yasser Osman Tarek Elsharkawy Tariq Mohammad Hashim Jumana Abdulwahab Alratroot Fatima Aljindan Liqa Almulla Hind Saleh Alsuwat Waad Mohammed Al Otaibi Fatma Mohammed Hegazi Abdallah M. Ibrahim J. Francis Borgio Sayed AbdulAzeez |
| author_sort | Yasser Osman |
| collection | DOAJ |
| description | The aim of this study is to investigate the single nucleotide polymorphisms (SNPs) associated with breast cancer in our population of Arab patients. We investigated 26 breast cancer patients and an equal number of healthy age- and sex-matched control volunteers. We examined the exome wide microarray-based biomarkers and screened 243,345 SNPs for their possible significant association with our breast cancer patients. Successfully, we identified the most significant (p value ≤9.14×10−09) four associated SNPs [SNRK and SNRK-AS1-rs202018563G; BRCA2-rs2227943C; ZNF484-rs199826847C; and DCPS-rs1695739G] among persons with breast cancer versus the healthy controls even after Bonferroni corrections (p value <2.05×10−07). Although our patients’ numbers were limited, the identified SNPs might shed some light on certain breast cancer-associated functional multigenic variations in Arab patients. We assert on the importance of more extensive large-scale analysis to confirm the candidate biomarkers and possible target genes of breast cancer among Arab ancestries. |
| format | Article |
| id | doaj-art-9bf7e9c3bd7d4a909bc2ab2d10f06466 |
| institution | Kabale University |
| issn | 2090-3189 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Breast Cancer |
| spelling | doaj-art-9bf7e9c3bd7d4a909bc2ab2d10f064662025-02-03T01:22:41ZengWileyInternational Journal of Breast Cancer2090-31892022-01-01202210.1155/2022/2442109Study of Single Nucleotide Polymorphisms Associated with Breast Cancer Patients among Arab AncestriesYasser Osman0Tarek Elsharkawy1Tariq Mohammad Hashim2Jumana Abdulwahab Alratroot3Fatima Aljindan4Liqa Almulla5Hind Saleh Alsuwat6Waad Mohammed Al Otaibi7Fatma Mohammed Hegazi8Abdallah M. Ibrahim9J. Francis Borgio10Sayed AbdulAzeez11Pathology DepartmentPathology DepartmentPathology DepartmentPathology DepartmentPathology DepartmentPathology DepartmentDepartment of Genetic ResearchDepartment of Genetic ResearchDepartment of Genetic ResearchDepartment of Genetic ResearchDepartment of Genetic ResearchDepartment of Genetic ResearchThe aim of this study is to investigate the single nucleotide polymorphisms (SNPs) associated with breast cancer in our population of Arab patients. We investigated 26 breast cancer patients and an equal number of healthy age- and sex-matched control volunteers. We examined the exome wide microarray-based biomarkers and screened 243,345 SNPs for their possible significant association with our breast cancer patients. Successfully, we identified the most significant (p value ≤9.14×10−09) four associated SNPs [SNRK and SNRK-AS1-rs202018563G; BRCA2-rs2227943C; ZNF484-rs199826847C; and DCPS-rs1695739G] among persons with breast cancer versus the healthy controls even after Bonferroni corrections (p value <2.05×10−07). Although our patients’ numbers were limited, the identified SNPs might shed some light on certain breast cancer-associated functional multigenic variations in Arab patients. We assert on the importance of more extensive large-scale analysis to confirm the candidate biomarkers and possible target genes of breast cancer among Arab ancestries.http://dx.doi.org/10.1155/2022/2442109 |
| spellingShingle | Yasser Osman Tarek Elsharkawy Tariq Mohammad Hashim Jumana Abdulwahab Alratroot Fatima Aljindan Liqa Almulla Hind Saleh Alsuwat Waad Mohammed Al Otaibi Fatma Mohammed Hegazi Abdallah M. Ibrahim J. Francis Borgio Sayed AbdulAzeez Study of Single Nucleotide Polymorphisms Associated with Breast Cancer Patients among Arab Ancestries International Journal of Breast Cancer |
| title | Study of Single Nucleotide Polymorphisms Associated with Breast Cancer Patients among Arab Ancestries |
| title_full | Study of Single Nucleotide Polymorphisms Associated with Breast Cancer Patients among Arab Ancestries |
| title_fullStr | Study of Single Nucleotide Polymorphisms Associated with Breast Cancer Patients among Arab Ancestries |
| title_full_unstemmed | Study of Single Nucleotide Polymorphisms Associated with Breast Cancer Patients among Arab Ancestries |
| title_short | Study of Single Nucleotide Polymorphisms Associated with Breast Cancer Patients among Arab Ancestries |
| title_sort | study of single nucleotide polymorphisms associated with breast cancer patients among arab ancestries |
| url | http://dx.doi.org/10.1155/2022/2442109 |
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