Hematopoietic stem cell transplantation in juvenile myelomonocytic leukemia: analyse one centre experience and literature review
Allogeneic hematopoietic stem cell transplantation (HSCT) is the standard curative therapy for juvenile myelomonocytic leukemia (JMML). Seventeen patients with JMML received myeloablative conditioning (busulfan-based — 15, treosulfan-based — 2). Donors included 5 matched related siblings, 8 — matche...
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| Language: | Russian |
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ABV-press
2014-07-01
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| Series: | Онкогематология |
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| Online Access: | https://oncohematology.abvpress.ru/ongm/article/view/105 |
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| author | M. A. Maschan L. A. Khachatryan Yu. V. Skvortsova E. E. Kurnikova D. A. Shasheleva V. O. Bobrynina D. N. Balashov E. V. Skorobogatova D. D. Baydildina G. A. Novichkova A. A. Maschan |
| author_facet | M. A. Maschan L. A. Khachatryan Yu. V. Skvortsova E. E. Kurnikova D. A. Shasheleva V. O. Bobrynina D. N. Balashov E. V. Skorobogatova D. D. Baydildina G. A. Novichkova A. A. Maschan |
| author_sort | M. A. Maschan |
| collection | DOAJ |
| description | Allogeneic hematopoietic stem cell transplantation (HSCT) is the standard curative therapy for juvenile myelomonocytic leukemia (JMML). Seventeen patients with JMML received myeloablative conditioning (busulfan-based — 15, treosulfan-based — 2). Donors included 5 matched related siblings, 8 — matched unrelated volunteer or cord blood (2), 4 — mismatched relatives. Primary engraftment was achieved in 75 %. The rate of acute GVHD grade II–IV was 58 %, grade III–IV — 23 %. Chronic GVHD occurred in 33 % of patients. Five JMML relapses occurred. Relapse-free survival is 66 ± 12 %. Four patients died of transplant-related complications. TRM was 28 ± 12 %.Five patients died of disease progression. Overall survival is 38 ± 13 % with median follow-up of 13 months. A review of most important publications related to HSCT in JMML is provided. |
| format | Article |
| id | doaj-art-9bf29edc00a84e1c93d1e32f064b96fd |
| institution | Kabale University |
| issn | 1818-8346 2413-4023 |
| language | Russian |
| publishDate | 2014-07-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Онкогематология |
| spelling | doaj-art-9bf29edc00a84e1c93d1e32f064b96fd2025-08-20T03:35:33ZrusABV-pressОнкогематология1818-83462413-40232014-07-0161455510.17650/1818-8346-2011-6-1-45-55120Hematopoietic stem cell transplantation in juvenile myelomonocytic leukemia: analyse one centre experience and literature reviewM. A. Maschan0L. A. Khachatryan1Yu. V. Skvortsova2E. E. Kurnikova3D. A. Shasheleva4V. O. Bobrynina5D. N. Balashov6E. V. Skorobogatova7D. D. Baydildina8G. A. Novichkova9A. A. Maschan10Federal Research Center of Pediatric Hematology, Oncology and ImmunologyFederal Research Center of Pediatric Hematology, Oncology and ImmunologyFederal Research Center of Pediatric Hematology, Oncology and ImmunologyRussian Children Clinical HospitalFederal Research Center of Pediatric Hematology, Oncology and ImmunologyFederal Research Center of Pediatric Hematology, Oncology and ImmunologyFederal Research Center of Pediatric Hematology, Oncology and ImmunologyFederal Research Center of Pediatric Hematology, Oncology and ImmunologyFederal Research Center of Pediatric Hematology, Oncology and ImmunologyFederal Research Center of Pediatric Hematology, Oncology and ImmunologyFederal Research Center of Pediatric Hematology, Oncology and ImmunologyAllogeneic hematopoietic stem cell transplantation (HSCT) is the standard curative therapy for juvenile myelomonocytic leukemia (JMML). Seventeen patients with JMML received myeloablative conditioning (busulfan-based — 15, treosulfan-based — 2). Donors included 5 matched related siblings, 8 — matched unrelated volunteer or cord blood (2), 4 — mismatched relatives. Primary engraftment was achieved in 75 %. The rate of acute GVHD grade II–IV was 58 %, grade III–IV — 23 %. Chronic GVHD occurred in 33 % of patients. Five JMML relapses occurred. Relapse-free survival is 66 ± 12 %. Four patients died of transplant-related complications. TRM was 28 ± 12 %.Five patients died of disease progression. Overall survival is 38 ± 13 % with median follow-up of 13 months. A review of most important publications related to HSCT in JMML is provided.https://oncohematology.abvpress.ru/ongm/article/view/105hematopoietic stem cell transplantationjuvenile myelomonocytic leukemiatransplant-related mortalityrelapse |
| spellingShingle | M. A. Maschan L. A. Khachatryan Yu. V. Skvortsova E. E. Kurnikova D. A. Shasheleva V. O. Bobrynina D. N. Balashov E. V. Skorobogatova D. D. Baydildina G. A. Novichkova A. A. Maschan Hematopoietic stem cell transplantation in juvenile myelomonocytic leukemia: analyse one centre experience and literature review Онкогематология hematopoietic stem cell transplantation juvenile myelomonocytic leukemia transplant-related mortality relapse |
| title | Hematopoietic stem cell transplantation in juvenile myelomonocytic leukemia: analyse one centre experience and literature review |
| title_full | Hematopoietic stem cell transplantation in juvenile myelomonocytic leukemia: analyse one centre experience and literature review |
| title_fullStr | Hematopoietic stem cell transplantation in juvenile myelomonocytic leukemia: analyse one centre experience and literature review |
| title_full_unstemmed | Hematopoietic stem cell transplantation in juvenile myelomonocytic leukemia: analyse one centre experience and literature review |
| title_short | Hematopoietic stem cell transplantation in juvenile myelomonocytic leukemia: analyse one centre experience and literature review |
| title_sort | hematopoietic stem cell transplantation in juvenile myelomonocytic leukemia analyse one centre experience and literature review |
| topic | hematopoietic stem cell transplantation juvenile myelomonocytic leukemia transplant-related mortality relapse |
| url | https://oncohematology.abvpress.ru/ongm/article/view/105 |
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