Human microbiomes in cancer development and therapy
Abstract Colonies formed by bacteria, archaea, fungi, and viral groups and their genomes, metabolites, and expressed proteins constitute complex human microbiomes. An increasing evidences showed that carcinogenesis and disease progression were link to microbiomes. Different organ sources, their micr...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-04-01
|
| Series: | MedComm |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/mco2.221 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832589927551860736 |
|---|---|
| author | Chenglai Xia Jiyan Su Can Liu Zhikai Mai Shuanghong Yin Chuansheng Yang Liwu Fu |
| author_facet | Chenglai Xia Jiyan Su Can Liu Zhikai Mai Shuanghong Yin Chuansheng Yang Liwu Fu |
| author_sort | Chenglai Xia |
| collection | DOAJ |
| description | Abstract Colonies formed by bacteria, archaea, fungi, and viral groups and their genomes, metabolites, and expressed proteins constitute complex human microbiomes. An increasing evidences showed that carcinogenesis and disease progression were link to microbiomes. Different organ sources, their microbial species, and their metabolites are different; the mechanisms of carcinogenic or procancerous are also different. Here, we summarize how microbiomes contribute to carcinogenesis and disease progression in cancers of the skin, mouth, esophagus, lung, gastrointestinal, genital, blood, and lymph malignancy. We also insight into the molecular mechanisms of triggering, promoting, or inhibiting carcinogenesis and disease progress induced by microbiomes or/and their secretions of bioactive metabolites. And then, the strategies of application of microorganisms in cancer treatment were discussed in detail. However, the mechanisms by which human microbiomes function are still poorly understood. The bidirectional interactions between microbiotas and endocrine systems need to be clarified. Probiotics and prebiotics are believed to benefit human health via a variety of mechanisms, in particular, in tumor inhibition. It is largely unknown how microbial agents cause cancer or how cancer progresses. We expect this review may open new perspectives on possible therapeutic approaches of patients with cancer. |
| format | Article |
| id | doaj-art-9bf24271a5a644bf9d87fd87bfedeccd |
| institution | Kabale University |
| issn | 2688-2663 |
| language | English |
| publishDate | 2023-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | MedComm |
| spelling | doaj-art-9bf24271a5a644bf9d87fd87bfedeccd2025-01-24T05:36:29ZengWileyMedComm2688-26632023-04-0142n/an/a10.1002/mco2.221Human microbiomes in cancer development and therapyChenglai Xia0Jiyan Su1Can Liu2Zhikai Mai3Shuanghong Yin4Chuansheng Yang5Liwu Fu6Affiliated Foshan Maternity and Chlid Healthcare Hospital Southern Medical University, Foshan, China; School of Pharmaceutical Sciences, Southern Medical University Guangzhou ChinaAffiliated Foshan Maternity and Chlid Healthcare Hospital Southern Medical University, Foshan, China; School of Pharmaceutical Sciences, Southern Medical University Guangzhou ChinaAffiliated Foshan Maternity and Chlid Healthcare Hospital Southern Medical University, Foshan, China; School of Pharmaceutical Sciences, Southern Medical University Guangzhou ChinaAffiliated Foshan Maternity and Chlid Healthcare Hospital Southern Medical University, Foshan, China; School of Pharmaceutical Sciences, Southern Medical University Guangzhou ChinaAffiliated Foshan Maternity and Chlid Healthcare Hospital Southern Medical University, Foshan, China; School of Pharmaceutical Sciences, Southern Medical University Guangzhou ChinaDepartment of Head‐Neck and Breast Surgery Yuebei People's Hospital of Shantou University Shaoguan ChinaState Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine; Guangdong Esophageal Cancer Institute; Sun Yat‐sen University Cancer Center Guangzhou People's Republic of ChinaAbstract Colonies formed by bacteria, archaea, fungi, and viral groups and their genomes, metabolites, and expressed proteins constitute complex human microbiomes. An increasing evidences showed that carcinogenesis and disease progression were link to microbiomes. Different organ sources, their microbial species, and their metabolites are different; the mechanisms of carcinogenic or procancerous are also different. Here, we summarize how microbiomes contribute to carcinogenesis and disease progression in cancers of the skin, mouth, esophagus, lung, gastrointestinal, genital, blood, and lymph malignancy. We also insight into the molecular mechanisms of triggering, promoting, or inhibiting carcinogenesis and disease progress induced by microbiomes or/and their secretions of bioactive metabolites. And then, the strategies of application of microorganisms in cancer treatment were discussed in detail. However, the mechanisms by which human microbiomes function are still poorly understood. The bidirectional interactions between microbiotas and endocrine systems need to be clarified. Probiotics and prebiotics are believed to benefit human health via a variety of mechanisms, in particular, in tumor inhibition. It is largely unknown how microbial agents cause cancer or how cancer progresses. We expect this review may open new perspectives on possible therapeutic approaches of patients with cancer.https://doi.org/10.1002/mco2.221cancer therapycarcinogenesismicrobiomemicroorganismtumor |
| spellingShingle | Chenglai Xia Jiyan Su Can Liu Zhikai Mai Shuanghong Yin Chuansheng Yang Liwu Fu Human microbiomes in cancer development and therapy MedComm cancer therapy carcinogenesis microbiome microorganism tumor |
| title | Human microbiomes in cancer development and therapy |
| title_full | Human microbiomes in cancer development and therapy |
| title_fullStr | Human microbiomes in cancer development and therapy |
| title_full_unstemmed | Human microbiomes in cancer development and therapy |
| title_short | Human microbiomes in cancer development and therapy |
| title_sort | human microbiomes in cancer development and therapy |
| topic | cancer therapy carcinogenesis microbiome microorganism tumor |
| url | https://doi.org/10.1002/mco2.221 |
| work_keys_str_mv | AT chenglaixia humanmicrobiomesincancerdevelopmentandtherapy AT jiyansu humanmicrobiomesincancerdevelopmentandtherapy AT canliu humanmicrobiomesincancerdevelopmentandtherapy AT zhikaimai humanmicrobiomesincancerdevelopmentandtherapy AT shuanghongyin humanmicrobiomesincancerdevelopmentandtherapy AT chuanshengyang humanmicrobiomesincancerdevelopmentandtherapy AT liwufu humanmicrobiomesincancerdevelopmentandtherapy |