Osteomimetic bioceramic scaffolds with high-fidelity human-bone features produced by rotational printing
Scaffolds that emulate the architecture of human bone, combined with strong mechanical stability and biocompatibility, are vital for promoting effective bone tissue regeneration. However, most existing bone-mimetic scaffolds fall short in reproducing the intricate hierarchical structure of human bon...
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| Format: | Article |
| Language: | English |
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IOP Publishing
2025-01-01
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| Series: | International Journal of Extreme Manufacturing |
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| Online Access: | https://doi.org/10.1088/2631-7990/ada7aa |
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| author | Shumin Pang Dongwei Wu Dorian A H Hanaor Astrid Haibel Jens Kurreck Aleksander Gurlo |
| author_facet | Shumin Pang Dongwei Wu Dorian A H Hanaor Astrid Haibel Jens Kurreck Aleksander Gurlo |
| author_sort | Shumin Pang |
| collection | DOAJ |
| description | Scaffolds that emulate the architecture of human bone, combined with strong mechanical stability and biocompatibility, are vital for promoting effective bone tissue regeneration. However, most existing bone-mimetic scaffolds fall short in reproducing the intricate hierarchical structure of human bone, which restricts their practical application. This study introduces a novel strategy that combines rotational three-dimensional (3D) printing technology and sponge replication technique to fabricate bone-mimetic scaffolds based on composite materials comprising copper-substituted diopside and biphasic calcium phosphate. The scaffolds closely mimic the structure of human bone, featuring both cancellous and cortical bone with Haversian canals. Additionally, the scaffolds exhibit high porosity and transport capacity, while exhibiting compressive strength that is on par with human bone under both axial and lateral loads. Moreover, they demonstrate good biocompatibility and the potential to induce and support osteogenesis and angiogenesis. The scaffolds produced here present a pathway to remediating particularly large bone defects. Given their close resemblance to human bone structure and function, these scaffolds may be well-suited for developing in vitro bone disease models for pharmaceutical testing and various biomedical applications. |
| format | Article |
| id | doaj-art-9bf13df448ec4860bf5f5a354ebc4efb |
| institution | Kabale University |
| issn | 2631-7990 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | IOP Publishing |
| record_format | Article |
| series | International Journal of Extreme Manufacturing |
| spelling | doaj-art-9bf13df448ec4860bf5f5a354ebc4efb2025-02-06T12:42:56ZengIOP PublishingInternational Journal of Extreme Manufacturing2631-79902025-01-017303500510.1088/2631-7990/ada7aaOsteomimetic bioceramic scaffolds with high-fidelity human-bone features produced by rotational printingShumin Pang0https://orcid.org/0000-0001-6677-121XDongwei Wu1https://orcid.org/0000-0001-5446-7376Dorian A H Hanaor2Astrid Haibel3Jens Kurreck4https://orcid.org/0000-0002-1469-0052Aleksander Gurlo5https://orcid.org/0000-0001-7047-666XTechnische Universität Berlin , Chair of Advanced Ceramic Materials, Straße des 17. Juni 135, 10623 Berlin, GermanyTechnische Universität Berlin, Chair of Applied Biochemistry , Gustav-Meyer-Allee 25, 13355 Berlin, GermanyTechnische Universität Berlin , Chair of Advanced Ceramic Materials, Straße des 17. Juni 135, 10623 Berlin, GermanyBerliner Hochschule für Technik , Fachbereich II Mathematics-Physics-Chemistry, Luxemburger Str. 10, 13353 Berlin, GermanyTechnische Universität Berlin, Chair of Applied Biochemistry , Gustav-Meyer-Allee 25, 13355 Berlin, GermanyTechnische Universität Berlin , Chair of Advanced Ceramic Materials, Straße des 17. Juni 135, 10623 Berlin, GermanyScaffolds that emulate the architecture of human bone, combined with strong mechanical stability and biocompatibility, are vital for promoting effective bone tissue regeneration. However, most existing bone-mimetic scaffolds fall short in reproducing the intricate hierarchical structure of human bone, which restricts their practical application. This study introduces a novel strategy that combines rotational three-dimensional (3D) printing technology and sponge replication technique to fabricate bone-mimetic scaffolds based on composite materials comprising copper-substituted diopside and biphasic calcium phosphate. The scaffolds closely mimic the structure of human bone, featuring both cancellous and cortical bone with Haversian canals. Additionally, the scaffolds exhibit high porosity and transport capacity, while exhibiting compressive strength that is on par with human bone under both axial and lateral loads. Moreover, they demonstrate good biocompatibility and the potential to induce and support osteogenesis and angiogenesis. The scaffolds produced here present a pathway to remediating particularly large bone defects. Given their close resemblance to human bone structure and function, these scaffolds may be well-suited for developing in vitro bone disease models for pharmaceutical testing and various biomedical applications.https://doi.org/10.1088/2631-7990/ada7aaadvanced manufacturing techniquesrotational 3D printingbone-mimetic scaffoldhierarchical structuremechanical strengthosteogenesis and angiogenesis |
| spellingShingle | Shumin Pang Dongwei Wu Dorian A H Hanaor Astrid Haibel Jens Kurreck Aleksander Gurlo Osteomimetic bioceramic scaffolds with high-fidelity human-bone features produced by rotational printing International Journal of Extreme Manufacturing advanced manufacturing techniques rotational 3D printing bone-mimetic scaffold hierarchical structure mechanical strength osteogenesis and angiogenesis |
| title | Osteomimetic bioceramic scaffolds with high-fidelity human-bone features produced by rotational printing |
| title_full | Osteomimetic bioceramic scaffolds with high-fidelity human-bone features produced by rotational printing |
| title_fullStr | Osteomimetic bioceramic scaffolds with high-fidelity human-bone features produced by rotational printing |
| title_full_unstemmed | Osteomimetic bioceramic scaffolds with high-fidelity human-bone features produced by rotational printing |
| title_short | Osteomimetic bioceramic scaffolds with high-fidelity human-bone features produced by rotational printing |
| title_sort | osteomimetic bioceramic scaffolds with high fidelity human bone features produced by rotational printing |
| topic | advanced manufacturing techniques rotational 3D printing bone-mimetic scaffold hierarchical structure mechanical strength osteogenesis and angiogenesis |
| url | https://doi.org/10.1088/2631-7990/ada7aa |
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