Animal Models of Chronic Pancreatitis
Animal models for CP in rats can be classified into 2 groups: one is noninvasive or nonsurgical models and the other is invasive or surgical models. Pancreatic injury induced by repetitive injections of supramaximal stimulatory dose of caerulein (Cn) or by intraductal infusion of sodium taurocholate...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2010/403295 |
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| author | Makoto Otsuki Mitsuyoshi Yamamoto Taizo Yamaguchi |
| author_facet | Makoto Otsuki Mitsuyoshi Yamamoto Taizo Yamaguchi |
| author_sort | Makoto Otsuki |
| collection | DOAJ |
| description | Animal models for CP in rats can be classified into 2 groups: one is noninvasive or nonsurgical models and the other is invasive or surgical models. Pancreatic injury induced by repetitive injections of supramaximal stimulatory dose of caerulein (Cn) or by intraductal infusion of sodium taurocholate (NaTc) recovered within 14 days, whereas that caused by repetitive injection of arginine or by intraductal infusion of oleic acid was persistent. However, the destroyed acinar tissues were replaced by fatty tissues without fibrosis. Transient stasis of pancreatic fluid flow by 0.01% agarose and minimum injury of the pancreatic duct by 0.1% NaTc solution induced progressive pancreatic injury although one alone is insufficient to cause persistent pancreatic injury. However, the damaged tissue was replaced by fatty tissue without fibrosis. Continuous pancreatic ductal hypertension (PDH) caused diffuse interlobular and intralobular fibrosis closely resembling human CP. |
| format | Article |
| id | doaj-art-9bec9aa0ea37423986c30596b03bc9b4 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-9bec9aa0ea37423986c30596b03bc9b42025-02-03T05:57:34ZengWileyGastroenterology Research and Practice1687-61211687-630X2010-01-01201010.1155/2010/403295403295Animal Models of Chronic PancreatitisMakoto Otsuki0Mitsuyoshi Yamamoto1Taizo Yamaguchi2Department of Lifestyle-related Diseases and Dietary Life, Graduate School of Life Science, Kobe Women's University, 2-1 Aoyama, Higashi-Suma, Suma-ku, Kobe 654-8585, JapanDepartment of Gastroenterology and Metabolism, School of Medicine, University of Occupational and Environmental Health Japan, Fukuoko 807-8555, JapanDepartment of Gastroenterology and Metabolism, School of Medicine, University of Occupational and Environmental Health Japan, Fukuoko 807-8555, JapanAnimal models for CP in rats can be classified into 2 groups: one is noninvasive or nonsurgical models and the other is invasive or surgical models. Pancreatic injury induced by repetitive injections of supramaximal stimulatory dose of caerulein (Cn) or by intraductal infusion of sodium taurocholate (NaTc) recovered within 14 days, whereas that caused by repetitive injection of arginine or by intraductal infusion of oleic acid was persistent. However, the destroyed acinar tissues were replaced by fatty tissues without fibrosis. Transient stasis of pancreatic fluid flow by 0.01% agarose and minimum injury of the pancreatic duct by 0.1% NaTc solution induced progressive pancreatic injury although one alone is insufficient to cause persistent pancreatic injury. However, the damaged tissue was replaced by fatty tissue without fibrosis. Continuous pancreatic ductal hypertension (PDH) caused diffuse interlobular and intralobular fibrosis closely resembling human CP.http://dx.doi.org/10.1155/2010/403295 |
| spellingShingle | Makoto Otsuki Mitsuyoshi Yamamoto Taizo Yamaguchi Animal Models of Chronic Pancreatitis Gastroenterology Research and Practice |
| title | Animal Models of Chronic Pancreatitis |
| title_full | Animal Models of Chronic Pancreatitis |
| title_fullStr | Animal Models of Chronic Pancreatitis |
| title_full_unstemmed | Animal Models of Chronic Pancreatitis |
| title_short | Animal Models of Chronic Pancreatitis |
| title_sort | animal models of chronic pancreatitis |
| url | http://dx.doi.org/10.1155/2010/403295 |
| work_keys_str_mv | AT makotootsuki animalmodelsofchronicpancreatitis AT mitsuyoshiyamamoto animalmodelsofchronicpancreatitis AT taizoyamaguchi animalmodelsofchronicpancreatitis |