Study of correlation between calcification regulatory factors and cognitive impairment in maintenance hemodialysis patients
ObjectiveTo evaluate the correlation of serum dephosphorylated uncarboxylated matrix Gla protein （dp-ucMGP） and bone morphogenetic protein-2 （BMP-2） with cognitive impairment （CI） in maintenance hemodialysis （MHD） patients.MethodsTwo hundred and fifty-four MHD patients in the First Affiliated Hospit...
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Editorial Department of Journal of Clinical Nephrology
2025-04-01
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| Series: | Linchuang shenzangbing zazhi |
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| Online Access: | http://www.lcszb.com/thesisDetails#10.3969/j.issn.1671-2390.2025.04.003 |
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| author | Luo Jie-yu Ding Zi-jun Zhang Chun-jiang Jin Xin Hao Wen-juan Zhao Dan |
| author_facet | Luo Jie-yu Ding Zi-jun Zhang Chun-jiang Jin Xin Hao Wen-juan Zhao Dan |
| author_sort | Luo Jie-yu |
| collection | DOAJ |
| description | ObjectiveTo evaluate the correlation of serum dephosphorylated uncarboxylated matrix Gla protein （dp-ucMGP） and bone morphogenetic protein-2 （BMP-2） with cognitive impairment （CI） in maintenance hemodialysis （MHD） patients.MethodsTwo hundred and fifty-four MHD patients in the First Affiliated Hospital of Shihezi University and Shihezi People's Hospital from June 1， 2021 to April 30， 2023 were selected. The general and laboratory data of the patients were collected. Cognitive function was evaluated with the Chinese version of Montreal Cognitive Assessment Scale （C-MoCA）. Enzyme-linked immunosorbent assay （ELISA） was used to measure serum dp-ucMGP and BMP-2.ResultsAmong the 254 patients included， 192 patients with CI were screened by the C-MoCA scale. Patients in the CI group had significantly older age ［57.0（50.0，67.7）years<italic> vs</italic> 48.0（35.0，54.0）years］， higher systolic blood pressure ［SBP， 137（129，148）mmHg<italic> vs</italic> 134（125，142）mmHg， 1 mmHg=0.133 kPa］， female proportion （40.1% <italic>vs</italic> 22.6%）， proportion of hypertension （76.6% <italic>vs</italic> 45.2%）， years of education （≤6 years： 30.7% <italic>vs</italic> 4.8%； >6， ≤9 years： 41.2% <italic>vs</italic> 27.4%）， serum dp-ucMGP ［9.05（7.81，10.71）μg/L<italic> vs</italic> 5.95（4.43，7.21）μg/L］， and serum BMP-2［114.72（101.07，140.44）ng/L<italic> vs</italic> 89.65（74.17，101.74）ng/L］， but lower proportion of high education level （>9， <13 years： 20.3% <italic>vs</italic> 45.2%； ≥13 years： 7.8% <italic>vs</italic> 22.6%） than those in the non-CI group （<italic>P</italic><0.05）. Binary Logistic regression analysis suggested that age， SBP and serum dp-ucMGP and BMP-2 were significantly correlated with CI in MHD patients （<italic>P<</italic>0.05）. Spearman correlation analysis showed that serum dp-ucMGP was negatively correlated with the C-MoCA score， and the scores of visuospatial/executive， attention， language， abstraction， delayed recall and orientation dimensions（<italic>P</italic><0.05）. Serum BMP-2 was negatively correlated with the C-MoCA score， and the scores of visuospatial/executive， naming， attention， language， abstraction and delayed recall dimensions（<italic>P</italic><0.05）.ConclusionSerum dp-ucMGP and BMP-2 are risk factors for CI in MHD patients， and their levels may be related to the severity of CI. |
| format | Article |
| id | doaj-art-9be81a29b9714f36aa34da3ce2e979b8 |
| institution | DOAJ |
| issn | 1671-2390 |
| language | zho |
| publishDate | 2025-04-01 |
| publisher | Editorial Department of Journal of Clinical Nephrology |
| record_format | Article |
| series | Linchuang shenzangbing zazhi |
| spelling | doaj-art-9be81a29b9714f36aa34da3ce2e979b82025-08-20T03:09:25ZzhoEditorial Department of Journal of Clinical NephrologyLinchuang shenzangbing zazhi1671-23902025-04-012528228890384770Study of correlation between calcification regulatory factors and cognitive impairment in maintenance hemodialysis patientsLuo Jie-yuDing Zi-junZhang Chun-jiangJin XinHao Wen-juanZhao DanObjectiveTo evaluate the correlation of serum dephosphorylated uncarboxylated matrix Gla protein （dp-ucMGP） and bone morphogenetic protein-2 （BMP-2） with cognitive impairment （CI） in maintenance hemodialysis （MHD） patients.MethodsTwo hundred and fifty-four MHD patients in the First Affiliated Hospital of Shihezi University and Shihezi People's Hospital from June 1， 2021 to April 30， 2023 were selected. The general and laboratory data of the patients were collected. Cognitive function was evaluated with the Chinese version of Montreal Cognitive Assessment Scale （C-MoCA）. Enzyme-linked immunosorbent assay （ELISA） was used to measure serum dp-ucMGP and BMP-2.ResultsAmong the 254 patients included， 192 patients with CI were screened by the C-MoCA scale. Patients in the CI group had significantly older age ［57.0（50.0，67.7）years<italic> vs</italic> 48.0（35.0，54.0）years］， higher systolic blood pressure ［SBP， 137（129，148）mmHg<italic> vs</italic> 134（125，142）mmHg， 1 mmHg=0.133 kPa］， female proportion （40.1% <italic>vs</italic> 22.6%）， proportion of hypertension （76.6% <italic>vs</italic> 45.2%）， years of education （≤6 years： 30.7% <italic>vs</italic> 4.8%； >6， ≤9 years： 41.2% <italic>vs</italic> 27.4%）， serum dp-ucMGP ［9.05（7.81，10.71）μg/L<italic> vs</italic> 5.95（4.43，7.21）μg/L］， and serum BMP-2［114.72（101.07，140.44）ng/L<italic> vs</italic> 89.65（74.17，101.74）ng/L］， but lower proportion of high education level （>9， <13 years： 20.3% <italic>vs</italic> 45.2%； ≥13 years： 7.8% <italic>vs</italic> 22.6%） than those in the non-CI group （<italic>P</italic><0.05）. Binary Logistic regression analysis suggested that age， SBP and serum dp-ucMGP and BMP-2 were significantly correlated with CI in MHD patients （<italic>P<</italic>0.05）. Spearman correlation analysis showed that serum dp-ucMGP was negatively correlated with the C-MoCA score， and the scores of visuospatial/executive， attention， language， abstraction， delayed recall and orientation dimensions（<italic>P</italic><0.05）. Serum BMP-2 was negatively correlated with the C-MoCA score， and the scores of visuospatial/executive， naming， attention， language， abstraction and delayed recall dimensions（<italic>P</italic><0.05）.ConclusionSerum dp-ucMGP and BMP-2 are risk factors for CI in MHD patients， and their levels may be related to the severity of CI.http://www.lcszb.com/thesisDetails#10.3969/j.issn.1671-2390.2025.04.003Maintenance hemodialysisCognitive impairmentDephosphorylated uncarboxylated matrix Gla proteinBone morphogenetic protein-2 |
| spellingShingle | Luo Jie-yu Ding Zi-jun Zhang Chun-jiang Jin Xin Hao Wen-juan Zhao Dan Study of correlation between calcification regulatory factors and cognitive impairment in maintenance hemodialysis patients Linchuang shenzangbing zazhi Maintenance hemodialysis Cognitive impairment Dephosphorylated uncarboxylated matrix Gla protein Bone morphogenetic protein-2 |
| title | Study of correlation between calcification regulatory factors and cognitive impairment in maintenance hemodialysis patients |
| title_full | Study of correlation between calcification regulatory factors and cognitive impairment in maintenance hemodialysis patients |
| title_fullStr | Study of correlation between calcification regulatory factors and cognitive impairment in maintenance hemodialysis patients |
| title_full_unstemmed | Study of correlation between calcification regulatory factors and cognitive impairment in maintenance hemodialysis patients |
| title_short | Study of correlation between calcification regulatory factors and cognitive impairment in maintenance hemodialysis patients |
| title_sort | study of correlation between calcification regulatory factors and cognitive impairment in maintenance hemodialysis patients |
| topic | Maintenance hemodialysis Cognitive impairment Dephosphorylated uncarboxylated matrix Gla protein Bone morphogenetic protein-2 |
| url | http://www.lcszb.com/thesisDetails#10.3969/j.issn.1671-2390.2025.04.003 |
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