Correlation between Thyroid Homeostasis and Obesity in Subclinical Hypothyroidism: Community-Based Cross-Sectional Research
Objective. It remains unknown whether obesity has an effect on the pituitary-thyroid feedback control axis in subclinical hypothyroidism (SCH). We aimed to investigate the association of thyroid homeostasis with obesity in a SCH population. Methods. Our study consisted of a community-based and cross...
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Wiley
2021-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2021/6663553 |
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| author | Yu Zhou Sujie Ke Kejun Wu Jingze Huang Xuelin Gao Beibei Li Xiaoying Lin Xiaohong Liu Xiaoying Liu Li Ma Linxi Wang Li Wu Lijuan Wu Chengwen Xie Junjun Xu Yanping Wang Libin Liu |
| author_facet | Yu Zhou Sujie Ke Kejun Wu Jingze Huang Xuelin Gao Beibei Li Xiaoying Lin Xiaohong Liu Xiaoying Liu Li Ma Linxi Wang Li Wu Lijuan Wu Chengwen Xie Junjun Xu Yanping Wang Libin Liu |
| author_sort | Yu Zhou |
| collection | DOAJ |
| description | Objective. It remains unknown whether obesity has an effect on the pituitary-thyroid feedback control axis in subclinical hypothyroidism (SCH). We aimed to investigate the association of thyroid homeostasis with obesity in a SCH population. Methods. Our study consisted of a community-based and cross-sectional study from the Epidemiological Survey of Thyroid Diseases in Fujian Province, China. A total of 193 subjects with SCH (90 males and 103 females) without a history of treatment of thyroid disease, such as surgery, radiation, and thyroid hormone or antithyroid medication, were included in the present study. Indices of obesity, including body mass index (BMI), waist circumference (WC), and waist-height ratio (WHtR) were measured. Results. Our results showed that the secretory capacity of the thyroid gland (SPINA-GT) and Jostel’s thyrotropin index (TSHI) were negatively correlated with BMI, WC, and WHtR, whereas the reciprocal of the thyrotroph thyroid hormone resistance index (TTSI-1) was positively correlated with BMI (all p<0.05). After adjustment for age, sex, smoking, iodine status, and glucolipid metabolism, the associations between TSHI, TTSI (reciprocal transformation), and BMI still persisted (all p<0.05). Conclusions. These results suggest that low levels of thyroid homeostasis indexes may be associated with overall obesity in SCH, rather than central adiposity. |
| format | Article |
| id | doaj-art-9bdfd83250394715ad6fe1277a5d6361 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-9bdfd83250394715ad6fe1277a5d63612025-02-03T05:49:15ZengWileyInternational Journal of Endocrinology1687-83371687-83452021-01-01202110.1155/2021/66635536663553Correlation between Thyroid Homeostasis and Obesity in Subclinical Hypothyroidism: Community-Based Cross-Sectional ResearchYu Zhou0Sujie Ke1Kejun Wu2Jingze Huang3Xuelin Gao4Beibei Li5Xiaoying Lin6Xiaohong Liu7Xiaoying Liu8Li Ma9Linxi Wang10Li Wu11Lijuan Wu12Chengwen Xie13Junjun Xu14Yanping Wang15Libin Liu16Department of Endocrinology and Metabolism, Fujian Medical University Union Hospital, Fuzhou 350001, Fujian, ChinaDepartment of Endocrinology and Metabolism, Fujian Medical University Union Hospital, Fuzhou 350001, Fujian, ChinaDepartment of Endocrinology and Metabolism, Fujian Medical University Union Hospital, Fuzhou 350001, Fujian, ChinaDepartment of Endocrinology and Metabolism, Fujian Medical University Union Hospital, Fuzhou 350001, Fujian, ChinaDepartment of Endocrinology and Metabolism, Fujian Medical University Union Hospital, Fuzhou 350001, Fujian, ChinaDepartment of Endocrinology and Metabolism, Fujian Medical University Union Hospital, Fuzhou 350001, Fujian, ChinaDepartment of Endocrinology and Metabolism, Fujian Medical University Union Hospital, Fuzhou 350001, Fujian, ChinaDepartment of Endocrinology and Metabolism, Fujian Medical University Union Hospital, Fuzhou 350001, Fujian, ChinaDepartment of Endocrinology and Metabolism, Fujian Medical University Union Hospital, Fuzhou 350001, Fujian, ChinaDepartment of Endocrinology and Metabolism, Fujian Medical University Union Hospital, Fuzhou 350001, Fujian, ChinaDepartment of Endocrinology and Metabolism, Fujian Medical University Union Hospital, Fuzhou 350001, Fujian, ChinaDepartment of Endocrinology and Metabolism, Fujian Medical University Union Hospital, Fuzhou 350001, Fujian, ChinaDepartment of Endocrinology and Metabolism, Fujian Medical University Union Hospital, Fuzhou 350001, Fujian, ChinaDepartment of Endocrinology and Metabolism, Fujian Medical University Union Hospital, Fuzhou 350001, Fujian, ChinaDepartment of Endocrinology and Metabolism, Fujian Medical University Union Hospital, Fuzhou 350001, Fujian, ChinaDepartment of Endocrinology and Metabolism, Fujian Medical University Union Hospital, Fuzhou 350001, Fujian, ChinaDepartment of Endocrinology and Metabolism, Fujian Medical University Union Hospital, Fuzhou 350001, Fujian, ChinaObjective. It remains unknown whether obesity has an effect on the pituitary-thyroid feedback control axis in subclinical hypothyroidism (SCH). We aimed to investigate the association of thyroid homeostasis with obesity in a SCH population. Methods. Our study consisted of a community-based and cross-sectional study from the Epidemiological Survey of Thyroid Diseases in Fujian Province, China. A total of 193 subjects with SCH (90 males and 103 females) without a history of treatment of thyroid disease, such as surgery, radiation, and thyroid hormone or antithyroid medication, were included in the present study. Indices of obesity, including body mass index (BMI), waist circumference (WC), and waist-height ratio (WHtR) were measured. Results. Our results showed that the secretory capacity of the thyroid gland (SPINA-GT) and Jostel’s thyrotropin index (TSHI) were negatively correlated with BMI, WC, and WHtR, whereas the reciprocal of the thyrotroph thyroid hormone resistance index (TTSI-1) was positively correlated with BMI (all p<0.05). After adjustment for age, sex, smoking, iodine status, and glucolipid metabolism, the associations between TSHI, TTSI (reciprocal transformation), and BMI still persisted (all p<0.05). Conclusions. These results suggest that low levels of thyroid homeostasis indexes may be associated with overall obesity in SCH, rather than central adiposity.http://dx.doi.org/10.1155/2021/6663553 |
| spellingShingle | Yu Zhou Sujie Ke Kejun Wu Jingze Huang Xuelin Gao Beibei Li Xiaoying Lin Xiaohong Liu Xiaoying Liu Li Ma Linxi Wang Li Wu Lijuan Wu Chengwen Xie Junjun Xu Yanping Wang Libin Liu Correlation between Thyroid Homeostasis and Obesity in Subclinical Hypothyroidism: Community-Based Cross-Sectional Research International Journal of Endocrinology |
| title | Correlation between Thyroid Homeostasis and Obesity in Subclinical Hypothyroidism: Community-Based Cross-Sectional Research |
| title_full | Correlation between Thyroid Homeostasis and Obesity in Subclinical Hypothyroidism: Community-Based Cross-Sectional Research |
| title_fullStr | Correlation between Thyroid Homeostasis and Obesity in Subclinical Hypothyroidism: Community-Based Cross-Sectional Research |
| title_full_unstemmed | Correlation between Thyroid Homeostasis and Obesity in Subclinical Hypothyroidism: Community-Based Cross-Sectional Research |
| title_short | Correlation between Thyroid Homeostasis and Obesity in Subclinical Hypothyroidism: Community-Based Cross-Sectional Research |
| title_sort | correlation between thyroid homeostasis and obesity in subclinical hypothyroidism community based cross sectional research |
| url | http://dx.doi.org/10.1155/2021/6663553 |
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