Whipple’s Disease: Our Own Experience and Review of the Literature
Whipple’s disease is a chronic infectious systemic disease caused by the bacterium Tropheryma whipplei. Nondeforming arthritis is frequently an initial complaint. Gastrointestinal and general symptoms include marked diarrhoea (with serious malabsorption), abdominal pain, prominent weight loss, and l...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2013/478349 |
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| author | Jan Bureš Marcela Kopáčová Tomáš Douda Jolana Bártová Jan Tomš Stanislav Rejchrt Ilja Tachecí |
| author_facet | Jan Bureš Marcela Kopáčová Tomáš Douda Jolana Bártová Jan Tomš Stanislav Rejchrt Ilja Tachecí |
| author_sort | Jan Bureš |
| collection | DOAJ |
| description | Whipple’s disease is a chronic infectious systemic disease caused by the bacterium Tropheryma whipplei. Nondeforming arthritis is frequently an initial complaint. Gastrointestinal and general symptoms include marked diarrhoea (with serious malabsorption), abdominal pain, prominent weight loss, and low-grade fever. Possible neurologic symptoms (up to 20%) might be associated with worse prognosis. Diagnosis is based on the clinical picture and small intestinal histology revealing foamy macrophages containing periodic-acid-Schiff- (PAS-) positive material. Long-term (up to one year) antibiotic therapy provides a favourable outcome in the vast majority of cases. This paper provides review of the literature and an analysis of our 5 patients recorded within a 20-year period at a tertiary gastroenterology centre. Patients were treated using i.v. penicillin G or amoxicillin-clavulanic acid + i.v. gentamicin for two weeks, followed by p.o. doxycycline (100 mg per day) plus p.o. salazopyrine (3 g per day) for 1 year. Full remission was achieved in all our patients. |
| format | Article |
| id | doaj-art-9bca53c7634e45529c06587224771c72 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-9bca53c7634e45529c06587224771c722025-02-03T06:05:06ZengWileyGastroenterology Research and Practice1687-61211687-630X2013-01-01201310.1155/2013/478349478349Whipple’s Disease: Our Own Experience and Review of the LiteratureJan Bureš0Marcela Kopáčová1Tomáš Douda2Jolana Bártová3Jan Tomš4Stanislav Rejchrt5Ilja Tachecí62nd Department of Medicine-Gastroenterology, Charles University in Praha, Faculty of Medicine at Hradec Králové, University Teaching Hospital, 50005 Hradec Králové, Czech Republic2nd Department of Medicine-Gastroenterology, Charles University in Praha, Faculty of Medicine at Hradec Králové, University Teaching Hospital, 50005 Hradec Králové, Czech Republic2nd Department of Medicine-Gastroenterology, Charles University in Praha, Faculty of Medicine at Hradec Králové, University Teaching Hospital, 50005 Hradec Králové, Czech Republic2nd Department of Medicine-Gastroenterology, Charles University in Praha, Faculty of Medicine at Hradec Králové, University Teaching Hospital, 50005 Hradec Králové, Czech Republic2nd Department of Medicine-Gastroenterology, Charles University in Praha, Faculty of Medicine at Hradec Králové, University Teaching Hospital, 50005 Hradec Králové, Czech Republic2nd Department of Medicine-Gastroenterology, Charles University in Praha, Faculty of Medicine at Hradec Králové, University Teaching Hospital, 50005 Hradec Králové, Czech Republic2nd Department of Medicine-Gastroenterology, Charles University in Praha, Faculty of Medicine at Hradec Králové, University Teaching Hospital, 50005 Hradec Králové, Czech RepublicWhipple’s disease is a chronic infectious systemic disease caused by the bacterium Tropheryma whipplei. Nondeforming arthritis is frequently an initial complaint. Gastrointestinal and general symptoms include marked diarrhoea (with serious malabsorption), abdominal pain, prominent weight loss, and low-grade fever. Possible neurologic symptoms (up to 20%) might be associated with worse prognosis. Diagnosis is based on the clinical picture and small intestinal histology revealing foamy macrophages containing periodic-acid-Schiff- (PAS-) positive material. Long-term (up to one year) antibiotic therapy provides a favourable outcome in the vast majority of cases. This paper provides review of the literature and an analysis of our 5 patients recorded within a 20-year period at a tertiary gastroenterology centre. Patients were treated using i.v. penicillin G or amoxicillin-clavulanic acid + i.v. gentamicin for two weeks, followed by p.o. doxycycline (100 mg per day) plus p.o. salazopyrine (3 g per day) for 1 year. Full remission was achieved in all our patients.http://dx.doi.org/10.1155/2013/478349 |
| spellingShingle | Jan Bureš Marcela Kopáčová Tomáš Douda Jolana Bártová Jan Tomš Stanislav Rejchrt Ilja Tachecí Whipple’s Disease: Our Own Experience and Review of the Literature Gastroenterology Research and Practice |
| title | Whipple’s Disease: Our Own Experience and Review of the Literature |
| title_full | Whipple’s Disease: Our Own Experience and Review of the Literature |
| title_fullStr | Whipple’s Disease: Our Own Experience and Review of the Literature |
| title_full_unstemmed | Whipple’s Disease: Our Own Experience and Review of the Literature |
| title_short | Whipple’s Disease: Our Own Experience and Review of the Literature |
| title_sort | whipple s disease our own experience and review of the literature |
| url | http://dx.doi.org/10.1155/2013/478349 |
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