Lessons Learned from Early Implementation and Scale-up of Stool-Based Xpert Testing to Diagnose Tuberculosis in Children
In 2020, fecal (stool) testing was recommended for diagnosing Mycobacterium tuberculosis complex (MTBC) infection in children by using the Cepheid Xpert MTB/RIF assay; since then, countries have begun implementing stool-based testing, often as part of a comprehensive strategy to enhance TB case fin...
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2025-03-01
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| Series: | Emerging Infectious Diseases |
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| Online Access: | https://wwwnc.cdc.gov/eid/article/31/3/24-1580_article |
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| author | Eveline Klinkenberg Petra de Haas Charles Manyonge Joanita Namutebi Bibiche Mujangi Hebert Mutunzi Amri Kingalu Nkiru Nwokoye Kuzani Mbendera Yohannes D. Babo Gulmira Kalmambetova Gunta Dravniece Winnie Mwanza Ahmed Bedru Degu D. Jerene Lisa V. Adams Andwele Mwansasu Charlotte Colvin |
| author_facet | Eveline Klinkenberg Petra de Haas Charles Manyonge Joanita Namutebi Bibiche Mujangi Hebert Mutunzi Amri Kingalu Nkiru Nwokoye Kuzani Mbendera Yohannes D. Babo Gulmira Kalmambetova Gunta Dravniece Winnie Mwanza Ahmed Bedru Degu D. Jerene Lisa V. Adams Andwele Mwansasu Charlotte Colvin |
| author_sort | Eveline Klinkenberg |
| collection | DOAJ |
| description |
In 2020, fecal (stool) testing was recommended for diagnosing Mycobacterium tuberculosis complex (MTBC) infection in children by using the Cepheid Xpert MTB/RIF assay; since then, countries have begun implementing stool-based testing, often as part of a comprehensive strategy to enhance TB case finding among children. On the basis of an experience-sharing workshop in November 2023, we determined insights of 9 early-adopter countries. Across those countries, 71,757 children underwent stool testing over a combined period of 121 months, October 2020–September 2023. A total of 2,892 children were positive for MTBC, and rifampin resistance was confirmed for 43 stool samples. The overall yield of MTBC detection across the countries was 4.1% (range 1.1%–17.3%). Stool collection for Xpert testing was considered noninvasive and as easy as sputum testing. Stool-based testing can be integrated into peripheral healthcare levels as a routine test to increase bacteriologic confirmation among children with presumptive TB.
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| format | Article |
| id | doaj-art-9bc22ee7a4dd4fdf9d51a8c5705f413d |
| institution | OA Journals |
| issn | 1080-6040 1080-6059 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj-art-9bc22ee7a4dd4fdf9d51a8c5705f413d2025-08-20T02:02:09ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592025-03-013131910.3201/eid3103.241580Lessons Learned from Early Implementation and Scale-up of Stool-Based Xpert Testing to Diagnose Tuberculosis in ChildrenEveline KlinkenbergPetra de HaasCharles ManyongeJoanita NamutebiBibiche MujangiHebert MutunziAmri KingaluNkiru NwokoyeKuzani MbenderaYohannes D. BaboGulmira KalmambetovaGunta DravnieceWinnie MwanzaAhmed BedruDegu D. JereneLisa V. AdamsAndwele MwansasuCharlotte Colvin In 2020, fecal (stool) testing was recommended for diagnosing Mycobacterium tuberculosis complex (MTBC) infection in children by using the Cepheid Xpert MTB/RIF assay; since then, countries have begun implementing stool-based testing, often as part of a comprehensive strategy to enhance TB case finding among children. On the basis of an experience-sharing workshop in November 2023, we determined insights of 9 early-adopter countries. Across those countries, 71,757 children underwent stool testing over a combined period of 121 months, October 2020–September 2023. A total of 2,892 children were positive for MTBC, and rifampin resistance was confirmed for 43 stool samples. The overall yield of MTBC detection across the countries was 4.1% (range 1.1%–17.3%). Stool collection for Xpert testing was considered noninvasive and as easy as sputum testing. Stool-based testing can be integrated into peripheral healthcare levels as a routine test to increase bacteriologic confirmation among children with presumptive TB. https://wwwnc.cdc.gov/eid/article/31/3/24-1580_articletuberculosisXpert MTB/RIF UltraNTPstoolfecal testingchildren |
| spellingShingle | Eveline Klinkenberg Petra de Haas Charles Manyonge Joanita Namutebi Bibiche Mujangi Hebert Mutunzi Amri Kingalu Nkiru Nwokoye Kuzani Mbendera Yohannes D. Babo Gulmira Kalmambetova Gunta Dravniece Winnie Mwanza Ahmed Bedru Degu D. Jerene Lisa V. Adams Andwele Mwansasu Charlotte Colvin Lessons Learned from Early Implementation and Scale-up of Stool-Based Xpert Testing to Diagnose Tuberculosis in Children Emerging Infectious Diseases tuberculosis Xpert MTB/RIF Ultra NTP stool fecal testing children |
| title | Lessons Learned from Early Implementation and Scale-up of Stool-Based Xpert Testing to Diagnose Tuberculosis in Children |
| title_full | Lessons Learned from Early Implementation and Scale-up of Stool-Based Xpert Testing to Diagnose Tuberculosis in Children |
| title_fullStr | Lessons Learned from Early Implementation and Scale-up of Stool-Based Xpert Testing to Diagnose Tuberculosis in Children |
| title_full_unstemmed | Lessons Learned from Early Implementation and Scale-up of Stool-Based Xpert Testing to Diagnose Tuberculosis in Children |
| title_short | Lessons Learned from Early Implementation and Scale-up of Stool-Based Xpert Testing to Diagnose Tuberculosis in Children |
| title_sort | lessons learned from early implementation and scale up of stool based xpert testing to diagnose tuberculosis in children |
| topic | tuberculosis Xpert MTB/RIF Ultra NTP stool fecal testing children |
| url | https://wwwnc.cdc.gov/eid/article/31/3/24-1580_article |
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