Impact of Obesity-Associated SARS-CoV-2 Mutations on COVID-19 Severity and Clinical Outcomes
This study explores the relationship between specific SARS-CoV-2 mutations and obesity, focusing on how these mutations may influence COVID-19 severity and outcomes in high-BMI individuals. We analyzed 205 viral mutations from a cohort of 675 patients, examining the association of mutations with BMI...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-12-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/17/1/38 |
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| author | Ana B. Martínez-Martinez Alexander Tristancho-Baró Beatriz Garcia-Rodriguez Marina Clavel-Millan Maria Pilar Palacian Ana Milagro Antonio Rezusta Jose M. Arbones-Mainar |
| author_facet | Ana B. Martínez-Martinez Alexander Tristancho-Baró Beatriz Garcia-Rodriguez Marina Clavel-Millan Maria Pilar Palacian Ana Milagro Antonio Rezusta Jose M. Arbones-Mainar |
| author_sort | Ana B. Martínez-Martinez |
| collection | DOAJ |
| description | This study explores the relationship between specific SARS-CoV-2 mutations and obesity, focusing on how these mutations may influence COVID-19 severity and outcomes in high-BMI individuals. We analyzed 205 viral mutations from a cohort of 675 patients, examining the association of mutations with BMI, hospitalization, and mortality rates. Logistic regression models and statistical analyses were applied to assess the impact of significant mutations on clinical outcomes, including inflammatory markers and antibody levels. Our findings revealed three key mutations—C14599T, A20268G, and C313T—that were associated with elevated BMI. Notably, C14599T appeared to be protective against hospitalization, suggesting context-dependent effects, while A20268G was linked to a 50% increase in hospitalization risk and elevated antibody levels, potentially indicating an adaptive immune response. C313T showed a 428% increase in mortality risk, marking it as a possible poor-prognosis marker. Interestingly, all three mutations were synonymous, suggesting adaptive roles in obesity-driven environments despite not altering viral protein structures. These results emphasize the importance of studying mutations within the broader context of comorbidities, other mutations, and regional factors to enhance our understanding of SARS-CoV-2 adaptation in high-risk groups. Further validation in larger cohorts is necessary to confirm these associations and to assess their clinical significance. |
| format | Article |
| id | doaj-art-9bbe8d88872744368fda156d53391671 |
| institution | Kabale University |
| issn | 1999-4915 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj-art-9bbe8d88872744368fda156d533916712025-01-24T13:52:20ZengMDPI AGViruses1999-49152024-12-011713810.3390/v17010038Impact of Obesity-Associated SARS-CoV-2 Mutations on COVID-19 Severity and Clinical OutcomesAna B. Martínez-Martinez0Alexander Tristancho-Baró1Beatriz Garcia-Rodriguez2Marina Clavel-Millan3Maria Pilar Palacian4Ana Milagro5Antonio Rezusta6Jose M. Arbones-Mainar7Facultad de Ciencias de la Salud, Universidad de Zaragoza, 50009 Zaragoza, SpainDepartment of Clinical Microbiology, Miguel Servet University Hospital, 50009 Zaragoza, SpainInstituto de Investigación Sanitaria Aragón, 50009 Zaragoza, SpainInstituto de Investigación Sanitaria Aragón, 50009 Zaragoza, SpainDepartment of Clinical Microbiology, Miguel Servet University Hospital, 50009 Zaragoza, SpainDepartment of Clinical Microbiology, Miguel Servet University Hospital, 50009 Zaragoza, SpainInstituto de Investigación Sanitaria Aragón, 50009 Zaragoza, SpainInstituto de Investigación Sanitaria Aragón, 50009 Zaragoza, SpainThis study explores the relationship between specific SARS-CoV-2 mutations and obesity, focusing on how these mutations may influence COVID-19 severity and outcomes in high-BMI individuals. We analyzed 205 viral mutations from a cohort of 675 patients, examining the association of mutations with BMI, hospitalization, and mortality rates. Logistic regression models and statistical analyses were applied to assess the impact of significant mutations on clinical outcomes, including inflammatory markers and antibody levels. Our findings revealed three key mutations—C14599T, A20268G, and C313T—that were associated with elevated BMI. Notably, C14599T appeared to be protective against hospitalization, suggesting context-dependent effects, while A20268G was linked to a 50% increase in hospitalization risk and elevated antibody levels, potentially indicating an adaptive immune response. C313T showed a 428% increase in mortality risk, marking it as a possible poor-prognosis marker. Interestingly, all three mutations were synonymous, suggesting adaptive roles in obesity-driven environments despite not altering viral protein structures. These results emphasize the importance of studying mutations within the broader context of comorbidities, other mutations, and regional factors to enhance our understanding of SARS-CoV-2 adaptation in high-risk groups. Further validation in larger cohorts is necessary to confirm these associations and to assess their clinical significance.https://www.mdpi.com/1999-4915/17/1/38COVID-19SARS-CoV-2obesitygenetic mutationsvirulencevaccine development |
| spellingShingle | Ana B. Martínez-Martinez Alexander Tristancho-Baró Beatriz Garcia-Rodriguez Marina Clavel-Millan Maria Pilar Palacian Ana Milagro Antonio Rezusta Jose M. Arbones-Mainar Impact of Obesity-Associated SARS-CoV-2 Mutations on COVID-19 Severity and Clinical Outcomes Viruses COVID-19 SARS-CoV-2 obesity genetic mutations virulence vaccine development |
| title | Impact of Obesity-Associated SARS-CoV-2 Mutations on COVID-19 Severity and Clinical Outcomes |
| title_full | Impact of Obesity-Associated SARS-CoV-2 Mutations on COVID-19 Severity and Clinical Outcomes |
| title_fullStr | Impact of Obesity-Associated SARS-CoV-2 Mutations on COVID-19 Severity and Clinical Outcomes |
| title_full_unstemmed | Impact of Obesity-Associated SARS-CoV-2 Mutations on COVID-19 Severity and Clinical Outcomes |
| title_short | Impact of Obesity-Associated SARS-CoV-2 Mutations on COVID-19 Severity and Clinical Outcomes |
| title_sort | impact of obesity associated sars cov 2 mutations on covid 19 severity and clinical outcomes |
| topic | COVID-19 SARS-CoV-2 obesity genetic mutations virulence vaccine development |
| url | https://www.mdpi.com/1999-4915/17/1/38 |
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