Pseudomonas aeruginosa quorum sensing and biofilm attenuation by a di-hydroxy derivative of piperlongumine (PL-18)

Pseudomonas aeruginosa quorum sensing and biofilm attenuation by a di-hydroxy derivative of piperlongumine (PL-18)

Bacterial communication, Quorum Sensing (QS), is a target against virulence and prevention of antibiotic-resistant infections. 16 derivatives of Piperlongumine (PL), an amide alkaloid from Piper longum L., were screened for QS inhibition. PL-18 had the best QSI activity. PL-18 inhibited the lasR-las...

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Bibliographic Details
Main Authors: Yael Schlichter Kadosh, Subramani Muthuraman, Khairun Nisaa, Anat Ben-Zvi, Danit Lisa Karsagi Byron, Marilou Shagan, Alexander Brandis, Tevie Mehlman, Jacob Gopas, Rajendran Saravana Kumar, Ariel Kushmaro
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Biofilm
Subjects:
Piperlongumine
Piper longum
Amide alkaloid
Pseudomonas aeruginosa
Quorum sensing
Bacterial biofilm
Online Access:http://www.sciencedirect.com/science/article/pii/S2590207524000406
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