From the Role of Microbiota in Gut-Lung Axis to SARS-CoV-2 Pathogenesis
Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) is responsible for the outbreak of a new viral respiratory infection. It has been demonstrated that the microbiota has a crucial role in establishing immune responses against respiratory infections, which are controlled by a bidirectional...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2021/6611222 |
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| _version_ | 1832547721374859264 |
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| author | Sara Ahmadi Badi Samira Tarashi Abolfazl Fateh Pejman Rohani Andrea Masotti Seyed Davar Siadat |
| author_facet | Sara Ahmadi Badi Samira Tarashi Abolfazl Fateh Pejman Rohani Andrea Masotti Seyed Davar Siadat |
| author_sort | Sara Ahmadi Badi |
| collection | DOAJ |
| description | Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) is responsible for the outbreak of a new viral respiratory infection. It has been demonstrated that the microbiota has a crucial role in establishing immune responses against respiratory infections, which are controlled by a bidirectional cross-talk, known as the “gut-lung axis.” The effects of microbiota on antiviral immune responses, including dendritic cell (DC) function and lymphocyte homing in the gut-lung axis, have been reported in the recent literature. Additionally, the gut microbiota composition affects (and is affected by) the expression of angiotensin-converting enzyme-2 (ACE2), which is the main receptor for SARS-CoV-2 and contributes to regulate inflammation. Several studies demonstrated an altered microbiota composition in patients infected with SARS-CoV-2, compared to healthy individuals. Furthermore, it has been shown that vaccine efficacy against viral respiratory infection is influenced by probiotics pretreatment. Therefore, the importance of the gut microbiota composition in the lung immune system and ACE2 expression could be valuable to provide optimal therapeutic approaches for SARS-CoV-2 and to preserve the symbiotic relationship of the microbiota with the host. |
| format | Article |
| id | doaj-art-9ba073a0168b4c8e8a6e0728cc98c0d8 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-9ba073a0168b4c8e8a6e0728cc98c0d82025-02-03T06:43:42ZengWileyMediators of Inflammation0962-93511466-18612021-01-01202110.1155/2021/66112226611222From the Role of Microbiota in Gut-Lung Axis to SARS-CoV-2 PathogenesisSara Ahmadi Badi0Samira Tarashi1Abolfazl Fateh2Pejman Rohani3Andrea Masotti4Seyed Davar Siadat5Microbiology Research Center, Pasteur Institute of Iran, Tehran, IranMicrobiology Research Center, Pasteur Institute of Iran, Tehran, IranMicrobiology Research Center, Pasteur Institute of Iran, Tehran, IranPediatric Gastroenterology, Hepatology and Nutrition Research Center Research Institute for Children Health, Tehran, IranChildren’s Hospital Bambino Gesù-IRCCS, Research Laboratories, V.le di San Paolo 15, 00146 Rome, ItalyMicrobiology Research Center, Pasteur Institute of Iran, Tehran, IranSevere acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) is responsible for the outbreak of a new viral respiratory infection. It has been demonstrated that the microbiota has a crucial role in establishing immune responses against respiratory infections, which are controlled by a bidirectional cross-talk, known as the “gut-lung axis.” The effects of microbiota on antiviral immune responses, including dendritic cell (DC) function and lymphocyte homing in the gut-lung axis, have been reported in the recent literature. Additionally, the gut microbiota composition affects (and is affected by) the expression of angiotensin-converting enzyme-2 (ACE2), which is the main receptor for SARS-CoV-2 and contributes to regulate inflammation. Several studies demonstrated an altered microbiota composition in patients infected with SARS-CoV-2, compared to healthy individuals. Furthermore, it has been shown that vaccine efficacy against viral respiratory infection is influenced by probiotics pretreatment. Therefore, the importance of the gut microbiota composition in the lung immune system and ACE2 expression could be valuable to provide optimal therapeutic approaches for SARS-CoV-2 and to preserve the symbiotic relationship of the microbiota with the host.http://dx.doi.org/10.1155/2021/6611222 |
| spellingShingle | Sara Ahmadi Badi Samira Tarashi Abolfazl Fateh Pejman Rohani Andrea Masotti Seyed Davar Siadat From the Role of Microbiota in Gut-Lung Axis to SARS-CoV-2 Pathogenesis Mediators of Inflammation |
| title | From the Role of Microbiota in Gut-Lung Axis to SARS-CoV-2 Pathogenesis |
| title_full | From the Role of Microbiota in Gut-Lung Axis to SARS-CoV-2 Pathogenesis |
| title_fullStr | From the Role of Microbiota in Gut-Lung Axis to SARS-CoV-2 Pathogenesis |
| title_full_unstemmed | From the Role of Microbiota in Gut-Lung Axis to SARS-CoV-2 Pathogenesis |
| title_short | From the Role of Microbiota in Gut-Lung Axis to SARS-CoV-2 Pathogenesis |
| title_sort | from the role of microbiota in gut lung axis to sars cov 2 pathogenesis |
| url | http://dx.doi.org/10.1155/2021/6611222 |
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