Cell-specific functions of androgen receptor in skeletal muscles
Androgens play a vital role not only in promoting the development of male sexual characteristics but also in exerting diverse physiological effects, including the regulation of skeletal muscle growth and function. Given that the effects of androgens are mediated through androgen receptor (AR) bindin...
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| Language: | English |
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The Japan Endocrine Society
2024-05-01
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| Series: | Endocrine Journal |
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| Online Access: | https://www.jstage.jst.go.jp/article/endocrj/71/5/71_EJ23-0691/_html/-char/en |
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| author | Hiroshi Sakai Yuuki Imai |
| author_facet | Hiroshi Sakai Yuuki Imai |
| author_sort | Hiroshi Sakai |
| collection | DOAJ |
| description | Androgens play a vital role not only in promoting the development of male sexual characteristics but also in exerting diverse physiological effects, including the regulation of skeletal muscle growth and function. Given that the effects of androgens are mediated through androgen receptor (AR) binding, an understanding of AR functionality is crucial for comprehending the mechanisms of androgen action on skeletal muscles. Drawing from insights gained using conditional knockout mouse models facilitated by Cre/loxP technology, we review the cell-specific functions of AR in skeletal muscles. We focus on three specific cell populations expressing AR within skeletal muscles: skeletal muscle cells, responsible for muscle contraction; satellite cells, which are essential stem cells contributing to the growth and regeneration of skeletal muscles; and mesenchymal progenitors, situated in interstitial areas and playing a crucial role in muscle homeostasis. Furthermore, the indirect effects of androgens on skeletal muscle through extra-muscle tissue are essential, especially for the regulation of skeletal muscle mass. The regulation of genes by AR varies across different cell types and contexts, including homeostasis, regeneration and hypertrophy of skeletal muscles. The varied mechanisms orchestrated by AR collectively influence the physiology of skeletal muscles. |
| format | Article |
| id | doaj-art-9b91883ab82b4d159615b7282db562f3 |
| institution | Kabale University |
| issn | 1348-4540 |
| language | English |
| publishDate | 2024-05-01 |
| publisher | The Japan Endocrine Society |
| record_format | Article |
| series | Endocrine Journal |
| spelling | doaj-art-9b91883ab82b4d159615b7282db562f32025-01-22T06:39:10ZengThe Japan Endocrine SocietyEndocrine Journal1348-45402024-05-0171543744510.1507/endocrj.EJ23-0691endocrjCell-specific functions of androgen receptor in skeletal musclesHiroshi Sakai0Yuuki Imai1Division of Integrative Pathophysiology, Proteo-Science Center, Ehime University, Ehime 791-0295, JapanDivision of Integrative Pathophysiology, Proteo-Science Center, Ehime University, Ehime 791-0295, JapanAndrogens play a vital role not only in promoting the development of male sexual characteristics but also in exerting diverse physiological effects, including the regulation of skeletal muscle growth and function. Given that the effects of androgens are mediated through androgen receptor (AR) binding, an understanding of AR functionality is crucial for comprehending the mechanisms of androgen action on skeletal muscles. Drawing from insights gained using conditional knockout mouse models facilitated by Cre/loxP technology, we review the cell-specific functions of AR in skeletal muscles. We focus on three specific cell populations expressing AR within skeletal muscles: skeletal muscle cells, responsible for muscle contraction; satellite cells, which are essential stem cells contributing to the growth and regeneration of skeletal muscles; and mesenchymal progenitors, situated in interstitial areas and playing a crucial role in muscle homeostasis. Furthermore, the indirect effects of androgens on skeletal muscle through extra-muscle tissue are essential, especially for the regulation of skeletal muscle mass. The regulation of genes by AR varies across different cell types and contexts, including homeostasis, regeneration and hypertrophy of skeletal muscles. The varied mechanisms orchestrated by AR collectively influence the physiology of skeletal muscles.https://www.jstage.jst.go.jp/article/endocrj/71/5/71_EJ23-0691/_html/-char/enandrogen receptorskeletal musclemyofiberssatellite cellsmesenchymal progenitors |
| spellingShingle | Hiroshi Sakai Yuuki Imai Cell-specific functions of androgen receptor in skeletal muscles Endocrine Journal androgen receptor skeletal muscle myofibers satellite cells mesenchymal progenitors |
| title | Cell-specific functions of androgen receptor in skeletal muscles |
| title_full | Cell-specific functions of androgen receptor in skeletal muscles |
| title_fullStr | Cell-specific functions of androgen receptor in skeletal muscles |
| title_full_unstemmed | Cell-specific functions of androgen receptor in skeletal muscles |
| title_short | Cell-specific functions of androgen receptor in skeletal muscles |
| title_sort | cell specific functions of androgen receptor in skeletal muscles |
| topic | androgen receptor skeletal muscle myofibers satellite cells mesenchymal progenitors |
| url | https://www.jstage.jst.go.jp/article/endocrj/71/5/71_EJ23-0691/_html/-char/en |
| work_keys_str_mv | AT hiroshisakai cellspecificfunctionsofandrogenreceptorinskeletalmuscles AT yuukiimai cellspecificfunctionsofandrogenreceptorinskeletalmuscles |