Dependence of Acute Myeloid Leukemia on Adhesion within the Bone Marrow Microenvironment

Dependence of Acute Myeloid Leukemia on Adhesion within the Bone Marrow Microenvironment

Acute myeloid leukemia (AML) cells home to the endosteal region of the bone marrow. They interact with bone marrow stromal components including extracellular matrix proteins, glycosaminoglycans, and stromal cells, by which they derive proliferative and growth inhibitory signals. Furthermore, adhesio...

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Bibliographic Details
Main Author:	Pamela S. Becker
Format:	Article
Language:	English
Published:	Wiley 2012-01-01
Series:	The Scientific World Journal
Online Access:	http://dx.doi.org/10.1100/2012/856467
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