Prognostic value of global plaque volume calculated from the 3D reconstruction of the coronary tree in patients without significant coronary artery disease. A multicenter study
ABSTRACT Introduction and objectives: The use of coronary physiology is essential to guide revascularization in patients with stable coronary artery disease. However, some patients without significant angiographic coronary artery disease will experience cardiovascular events at the follow-up. This s...
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| author | Carlos Cortés Julio Ruiz-Ruiz Fernando Rivero Ramón López-Palop Octavio Jiménez Alfonso Freites Luis R. Gonçalves-Ramírez María Rosario Ortas Nadal Sara Blasco Mario García-Gómez Clara Fernández Luca Scorpiglione J. Alberto San Román Calvar Ignacio J. Amat-Santos |
| author_facet | Carlos Cortés Julio Ruiz-Ruiz Fernando Rivero Ramón López-Palop Octavio Jiménez Alfonso Freites Luis R. Gonçalves-Ramírez María Rosario Ortas Nadal Sara Blasco Mario García-Gómez Clara Fernández Luca Scorpiglione J. Alberto San Román Calvar Ignacio J. Amat-Santos |
| author_sort | Carlos Cortés |
| collection | DOAJ |
| description | ABSTRACT Introduction and objectives: The use of coronary physiology is essential to guide revascularization in patients with stable coronary artery disease. However, some patients without significant angiographic coronary artery disease will experience cardiovascular events at the follow-up. This study aims to determine the prognostic value of the global plaque volume (GPV) in patients with stable coronary artery disease without functionally significant lesions at a 5-year follow-up. Methods: We conducted a multicenter, observational, and retrospective cohort study with a 5-year follow-up. A total of 277 patients without significant coronary artery disease treated with coronary angiography in 2015 due to suspected stable coronary artery disease were included in the study. The 3 coronary territories were assessed using quantitative flow ratio, calculating the GPV by determining the difference between the luminal volume and the vessel theoretical reference volume. Results: The mean GPV was 170.5 mm3. A total of 116 patients (42.7%) experienced major adverse cardiovascular events (MACE) at the follow-up, including cardiac death (11%), myocardial infarction (2.6%), and unexpected hospital admissions (38.1%). Patients with MACE had a significantly higher GPV (231.6 mm3 vs 111.8 mm3; P < .001). The optimal GPV cut-off point for predicting events was 44 mm3. Furthermore, in the multivariate analysis conducted, plaque volume, diabetes, hypertension, age, dyslipidemia, smoking, age, and GPV > 44 mm3 turned out to be independent predictors of MACE. Conclusions: GPV, calculated from the three-dimensional reconstruction of the coronary tree, is an independent predictor of events in patients with stable coronary artery disease without significant lesions. A GPV > 44 mm3 is an optimal cut-off point for predicting events. |
| format | Article |
| id | doaj-art-9b7b00a0e327488ca8baefbf1ca7a90b |
| institution | OA Journals |
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| publishDate | 2025-05-01 |
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| spelling | doaj-art-9b7b00a0e327488ca8baefbf1ca7a90b2025-08-20T01:50:41ZengPermanyerREC: Interventional Cardiology (English Ed.)2604-73222025-05-017210911410.24875/RECICE.M24000496Prognostic value of global plaque volume calculated from the 3D reconstruction of the coronary tree in patients without significant coronary artery disease. A multicenter studyCarlos Cortés0Julio Ruiz-Ruiz1Fernando Rivero2Ramón López-Palop3Octavio Jiménez4Alfonso Freites5Luis R. Gonçalves-Ramírez6María Rosario Ortas Nadal7Sara Blasco8Mario García-Gómez9Clara Fernández10Luca Scorpiglione11J. Alberto San Román Calvar12Ignacio J. Amat-Santos13Servicio de Cardiología, Hospital Clínico Universitario de Valladolid, Valladolid, Spain. Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), SpainServicio de Cardiología, Hospital Clínico Universitario de Valladolid, Valladolid, SpainServicio de Cardiología, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria del Hospital La Princesa, Madrid, SpainServicio de Cardiología, Hospital Universitario Virgen de la Arrixaca, El Palmar, Murcia, SpainServicio de Cardiología, Complejo Hospitalario de Navarra, Pamplona, Navarra, SpainServicio de Cardiología, Hospital General Universitario de Ciudad Real, Ciudad Real, SpainServicio de Cardiología, Complejo Asistencial Universitario de León, León, SpainServicio de Cardiología, Hospital Universitario Miguel Servet, Zaragoza, SpainServicio de Cardiología, Hospital Clínico Universitario de Valladolid, Valladolid, SpainServicio de Cardiología, Hospital Clínico Universitario de Valladolid, Valladolid, SpainServicio de Cardiología, Hospital Clínico Universitario de Valladolid, Valladolid, SpainServicio de Cardiología, Hospital Clínico Universitario de Valladolid, Valladolid, SpainServicio de Cardiología, Hospital Clínico Universitario de Valladolid, Valladolid, Spain. Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), SpainServicio de Cardiología, Hospital Clínico Universitario de Valladolid, Valladolid, Spain. Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), SpainABSTRACT Introduction and objectives: The use of coronary physiology is essential to guide revascularization in patients with stable coronary artery disease. However, some patients without significant angiographic coronary artery disease will experience cardiovascular events at the follow-up. This study aims to determine the prognostic value of the global plaque volume (GPV) in patients with stable coronary artery disease without functionally significant lesions at a 5-year follow-up. Methods: We conducted a multicenter, observational, and retrospective cohort study with a 5-year follow-up. A total of 277 patients without significant coronary artery disease treated with coronary angiography in 2015 due to suspected stable coronary artery disease were included in the study. The 3 coronary territories were assessed using quantitative flow ratio, calculating the GPV by determining the difference between the luminal volume and the vessel theoretical reference volume. Results: The mean GPV was 170.5 mm3. A total of 116 patients (42.7%) experienced major adverse cardiovascular events (MACE) at the follow-up, including cardiac death (11%), myocardial infarction (2.6%), and unexpected hospital admissions (38.1%). Patients with MACE had a significantly higher GPV (231.6 mm3 vs 111.8 mm3; P < .001). The optimal GPV cut-off point for predicting events was 44 mm3. Furthermore, in the multivariate analysis conducted, plaque volume, diabetes, hypertension, age, dyslipidemia, smoking, age, and GPV > 44 mm3 turned out to be independent predictors of MACE. Conclusions: GPV, calculated from the three-dimensional reconstruction of the coronary tree, is an independent predictor of events in patients with stable coronary artery disease without significant lesions. A GPV > 44 mm3 is an optimal cut-off point for predicting events.https://recintervcardiol.org/en/index.php?option=com_content&view=article&id=2646Coronary artery disease Coronary atherosclerosis Coronary angiography Global plaque volume Coronary physiology Quantitative flow ratio |
| spellingShingle | Carlos Cortés Julio Ruiz-Ruiz Fernando Rivero Ramón López-Palop Octavio Jiménez Alfonso Freites Luis R. Gonçalves-Ramírez María Rosario Ortas Nadal Sara Blasco Mario García-Gómez Clara Fernández Luca Scorpiglione J. Alberto San Román Calvar Ignacio J. Amat-Santos Prognostic value of global plaque volume calculated from the 3D reconstruction of the coronary tree in patients without significant coronary artery disease. A multicenter study REC: Interventional Cardiology (English Ed.) Coronary artery disease Coronary atherosclerosis Coronary angiography Global plaque volume Coronary physiology Quantitative flow ratio |
| title | Prognostic value of global plaque volume calculated from the 3D reconstruction of the coronary tree in patients without significant coronary artery disease. A multicenter study |
| title_full | Prognostic value of global plaque volume calculated from the 3D reconstruction of the coronary tree in patients without significant coronary artery disease. A multicenter study |
| title_fullStr | Prognostic value of global plaque volume calculated from the 3D reconstruction of the coronary tree in patients without significant coronary artery disease. A multicenter study |
| title_full_unstemmed | Prognostic value of global plaque volume calculated from the 3D reconstruction of the coronary tree in patients without significant coronary artery disease. A multicenter study |
| title_short | Prognostic value of global plaque volume calculated from the 3D reconstruction of the coronary tree in patients without significant coronary artery disease. A multicenter study |
| title_sort | prognostic value of global plaque volume calculated from the 3d reconstruction of the coronary tree in patients without significant coronary artery disease a multicenter study |
| topic | Coronary artery disease Coronary atherosclerosis Coronary angiography Global plaque volume Coronary physiology Quantitative flow ratio |
| url | https://recintervcardiol.org/en/index.php?option=com_content&view=article&id=2646 |
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