Rodent Models for Investigating the Dysregulation of Immune Responses in Type 1 Diabetes
Type 1 diabetes (T1D) is an autoimmune disease mediated by T cells that selectively destroy the insulin-producing β cells. Previous reports based on epidemiological and animal studies have demonstrated that both genetic factors and environmental parameters can either promote or attenuate the progres...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2013/138412 |
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| _version_ | 1832550644715618304 |
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| author | Feng-Cheng Chou Heng-Yi Chen Shyi-Jou Chen Mei-Cho Fang Huey-Kang Sytwu |
| author_facet | Feng-Cheng Chou Heng-Yi Chen Shyi-Jou Chen Mei-Cho Fang Huey-Kang Sytwu |
| author_sort | Feng-Cheng Chou |
| collection | DOAJ |
| description | Type 1 diabetes (T1D) is an autoimmune disease mediated by T cells that selectively destroy the insulin-producing β cells. Previous reports based on epidemiological and animal studies have demonstrated that both genetic factors and environmental parameters can either promote or attenuate the progression of autoimmunity. In recent decades, several inbred rodent strains that spontaneously develop diabetes have been applied to the investigation of the pathogenesis of T1D. Because the genetic manipulation of mice is well developed (transgenic, knockout, and conditional knockout/transgenic), most studies are performed using the nonobese diabetic (NOD) mouse model. This paper will focus on the use of genetically manipulated NOD mice to explore the pathogenesis of T1D and to develop potential therapeutic approaches. |
| format | Article |
| id | doaj-art-9b76c410ea704973a3645531391d38f1 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-9b76c410ea704973a3645531391d38f12025-02-03T06:06:18ZengWileyJournal of Diabetes Research2314-67452314-67532013-01-01201310.1155/2013/138412138412Rodent Models for Investigating the Dysregulation of Immune Responses in Type 1 DiabetesFeng-Cheng Chou0Heng-Yi Chen1Shyi-Jou Chen2Mei-Cho Fang3Huey-Kang Sytwu4Department and Graduate Institute of Microbiology and Immunology, National Defense Medical Center, R8324, 161, Section 6, MinChuan East Road, Neihu, Taipei 114, TaiwanDepartment and Graduate Institute of Microbiology and Immunology, National Defense Medical Center, R8324, 161, Section 6, MinChuan East Road, Neihu, Taipei 114, TaiwanDepartment of Pediatrics, Tri-Service General Hospital, 325, Section 2, Chenggong Road, Neihu, Taipei 114, TaiwanLaboratory Animal Center, National Defense Medical Center, Taipei 114, TaiwanDepartment and Graduate Institute of Microbiology and Immunology, National Defense Medical Center, R8324, 161, Section 6, MinChuan East Road, Neihu, Taipei 114, TaiwanType 1 diabetes (T1D) is an autoimmune disease mediated by T cells that selectively destroy the insulin-producing β cells. Previous reports based on epidemiological and animal studies have demonstrated that both genetic factors and environmental parameters can either promote or attenuate the progression of autoimmunity. In recent decades, several inbred rodent strains that spontaneously develop diabetes have been applied to the investigation of the pathogenesis of T1D. Because the genetic manipulation of mice is well developed (transgenic, knockout, and conditional knockout/transgenic), most studies are performed using the nonobese diabetic (NOD) mouse model. This paper will focus on the use of genetically manipulated NOD mice to explore the pathogenesis of T1D and to develop potential therapeutic approaches.http://dx.doi.org/10.1155/2013/138412 |
| spellingShingle | Feng-Cheng Chou Heng-Yi Chen Shyi-Jou Chen Mei-Cho Fang Huey-Kang Sytwu Rodent Models for Investigating the Dysregulation of Immune Responses in Type 1 Diabetes Journal of Diabetes Research |
| title | Rodent Models for Investigating the Dysregulation of Immune Responses in Type 1 Diabetes |
| title_full | Rodent Models for Investigating the Dysregulation of Immune Responses in Type 1 Diabetes |
| title_fullStr | Rodent Models for Investigating the Dysregulation of Immune Responses in Type 1 Diabetes |
| title_full_unstemmed | Rodent Models for Investigating the Dysregulation of Immune Responses in Type 1 Diabetes |
| title_short | Rodent Models for Investigating the Dysregulation of Immune Responses in Type 1 Diabetes |
| title_sort | rodent models for investigating the dysregulation of immune responses in type 1 diabetes |
| url | http://dx.doi.org/10.1155/2013/138412 |
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