Cytokines and Chemokines as Biomarkers of Community-Acquired Bacterial Infection
Routinely used biomarkers of bacterial etiology of infection, such as C-reactive protein and procalcitonin, have limited usefulness for evaluation of infections since their expression is enhanced by a number of different conditions. Therefore, several inflammatory cytokines and chemokines were analy...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2013/190145 |
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| author | Michal Holub David A. Lawrence Nancy Andersen Alžběta Davidová Ondřej Beran Vilma Marešová Pavel Chalupa |
| author_facet | Michal Holub David A. Lawrence Nancy Andersen Alžběta Davidová Ondřej Beran Vilma Marešová Pavel Chalupa |
| author_sort | Michal Holub |
| collection | DOAJ |
| description | Routinely used biomarkers of bacterial etiology of infection, such as C-reactive protein and procalcitonin, have limited usefulness for evaluation of infections since their expression is enhanced by a number of different conditions. Therefore, several inflammatory cytokines and chemokines were analyzed with sera from patients hospitalized for moderate bacterial and viral infectious diseases. In total, 57 subjects were enrolled: 21 patients with community-acquired bacterial infections, 26 patients with viral infections, and 10 healthy subjects (control cohorts). The laboratory analyses were performed using Luminex technology, and the following molecules were examined: IL-1Ra, IL-2, IL-4, IL-6, IL-8, TNF-α, INF-γ, MIP-1β, and MCP-1. Bacterial etiology of infection was associated with significantly (P<0.001) elevated serum concentrations of IL-1Ra, IL-2, IL-6, and TNF-α in comparison to levels observed in the sera of patients with viral infections. In the patients with bacterial infections, IL-1Ra and IL-8 demonstrated positive correlation with C-reactive protein, whereas, IL-1Ra, TNF-α, and MCP-1 correlated with procalcitonin. Furthermore, elevated levels of IL-1Ra, IL-6, and TNF-α decreased within 3 days of antibiotic therapy to levels observed in control subjects. The results show IL-1Ra as a potential useful biomarker of community-acquired bacterial infection. |
| format | Article |
| id | doaj-art-9b6d74e08e4a42f7987213bc9b84e430 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-9b6d74e08e4a42f7987213bc9b84e4302025-02-03T06:45:57ZengWileyMediators of Inflammation0962-93511466-18612013-01-01201310.1155/2013/190145190145Cytokines and Chemokines as Biomarkers of Community-Acquired Bacterial InfectionMichal Holub0David A. Lawrence1Nancy Andersen2Alžběta Davidová3Ondřej Beran4Vilma Marešová5Pavel Chalupa6Department of Infectious and Tropical Diseases, First Faculty of Medicine, Charles University in Prague and Na Bulovce Hospital, Prague, CZ 180 81, Czech RepublicLaboratory of Immunology, Wadsworth Center, NYS DOH, Albany, NY 12201-0509, USALaboratory of Immunology, Wadsworth Center, NYS DOH, Albany, NY 12201-0509, USADepartment of Infectious and Tropical Diseases, First Faculty of Medicine, Charles University in Prague and Na Bulovce Hospital, Prague, CZ 180 81, Czech RepublicDepartment of Infectious and Tropical Diseases, First Faculty of Medicine, Charles University in Prague and Na Bulovce Hospital, Prague, CZ 180 81, Czech RepublicDivision of Infectious Diseases, Institute of Postgraduate Medical Education and Na Bulovce Hospital, Prague, CZ 180 81, Czech RepublicDepartment of Infectious and Tropical Diseases, First Faculty of Medicine, Charles University in Prague and Na Bulovce Hospital, Prague, CZ 180 81, Czech RepublicRoutinely used biomarkers of bacterial etiology of infection, such as C-reactive protein and procalcitonin, have limited usefulness for evaluation of infections since their expression is enhanced by a number of different conditions. Therefore, several inflammatory cytokines and chemokines were analyzed with sera from patients hospitalized for moderate bacterial and viral infectious diseases. In total, 57 subjects were enrolled: 21 patients with community-acquired bacterial infections, 26 patients with viral infections, and 10 healthy subjects (control cohorts). The laboratory analyses were performed using Luminex technology, and the following molecules were examined: IL-1Ra, IL-2, IL-4, IL-6, IL-8, TNF-α, INF-γ, MIP-1β, and MCP-1. Bacterial etiology of infection was associated with significantly (P<0.001) elevated serum concentrations of IL-1Ra, IL-2, IL-6, and TNF-α in comparison to levels observed in the sera of patients with viral infections. In the patients with bacterial infections, IL-1Ra and IL-8 demonstrated positive correlation with C-reactive protein, whereas, IL-1Ra, TNF-α, and MCP-1 correlated with procalcitonin. Furthermore, elevated levels of IL-1Ra, IL-6, and TNF-α decreased within 3 days of antibiotic therapy to levels observed in control subjects. The results show IL-1Ra as a potential useful biomarker of community-acquired bacterial infection.http://dx.doi.org/10.1155/2013/190145 |
| spellingShingle | Michal Holub David A. Lawrence Nancy Andersen Alžběta Davidová Ondřej Beran Vilma Marešová Pavel Chalupa Cytokines and Chemokines as Biomarkers of Community-Acquired Bacterial Infection Mediators of Inflammation |
| title | Cytokines and Chemokines as Biomarkers of Community-Acquired Bacterial Infection |
| title_full | Cytokines and Chemokines as Biomarkers of Community-Acquired Bacterial Infection |
| title_fullStr | Cytokines and Chemokines as Biomarkers of Community-Acquired Bacterial Infection |
| title_full_unstemmed | Cytokines and Chemokines as Biomarkers of Community-Acquired Bacterial Infection |
| title_short | Cytokines and Chemokines as Biomarkers of Community-Acquired Bacterial Infection |
| title_sort | cytokines and chemokines as biomarkers of community acquired bacterial infection |
| url | http://dx.doi.org/10.1155/2013/190145 |
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