Synthesis and Analgesic Activity of Novel Derivatives of 1,2-Substituted Benzimidazoles
A series of novel 2-phenylhydrazinomethyl and 2-(2-hydroxyphenyl)-benzimidazole derivatives substituted at the N1-position of benzimidazole nucleus were synthesized as well as screened for analgesic activity. Some of these compounds showed promising analgesic activity when compared with the standard...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2013/694295 |
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| _version_ | 1832565802348314624 |
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| author | Shobhit Srivastava S. N. Pandeya Meena K. Yadav B. K. Singh |
| author_facet | Shobhit Srivastava S. N. Pandeya Meena K. Yadav B. K. Singh |
| author_sort | Shobhit Srivastava |
| collection | DOAJ |
| description | A series of novel 2-phenylhydrazinomethyl and 2-(2-hydroxyphenyl)-benzimidazole derivatives substituted at the N1-position of benzimidazole nucleus were synthesized as well as screened for analgesic activity. Some of these compounds showed promising analgesic activity when compared with the standard drug diclofenac sodium. The incorporation of a phenylhydrazinomethyl nucleus at 2-position of benzimidazole compound gave a biologically active pharmacophore. |
| format | Article |
| id | doaj-art-9b67425272574b6d944c47c72ec249fa |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-9b67425272574b6d944c47c72ec249fa2025-02-03T01:06:44ZengWileyJournal of Chemistry2090-90632090-90712013-01-01201310.1155/2013/694295694295Synthesis and Analgesic Activity of Novel Derivatives of 1,2-Substituted BenzimidazolesShobhit Srivastava0S. N. Pandeya1Meena K. Yadav2B. K. Singh3Department of Pharmaceutical Chemistry, Saroj Institute of Technology & Management, Lucknow, UP 226002, IndiaDepartment of Pharmaceutical Chemistry, Saroj Institute of Technology & Management, Lucknow, UP 226002, IndiaDepartment of Pharmaceutical Chemistry, Saroj Institute of Technology & Management, Lucknow, UP 226002, IndiaDepartment of Pharmaceutical Chemistry, Saroj Institute of Technology & Management, Lucknow, UP 226002, IndiaA series of novel 2-phenylhydrazinomethyl and 2-(2-hydroxyphenyl)-benzimidazole derivatives substituted at the N1-position of benzimidazole nucleus were synthesized as well as screened for analgesic activity. Some of these compounds showed promising analgesic activity when compared with the standard drug diclofenac sodium. The incorporation of a phenylhydrazinomethyl nucleus at 2-position of benzimidazole compound gave a biologically active pharmacophore.http://dx.doi.org/10.1155/2013/694295 |
| spellingShingle | Shobhit Srivastava S. N. Pandeya Meena K. Yadav B. K. Singh Synthesis and Analgesic Activity of Novel Derivatives of 1,2-Substituted Benzimidazoles Journal of Chemistry |
| title | Synthesis and Analgesic Activity of Novel Derivatives of 1,2-Substituted Benzimidazoles |
| title_full | Synthesis and Analgesic Activity of Novel Derivatives of 1,2-Substituted Benzimidazoles |
| title_fullStr | Synthesis and Analgesic Activity of Novel Derivatives of 1,2-Substituted Benzimidazoles |
| title_full_unstemmed | Synthesis and Analgesic Activity of Novel Derivatives of 1,2-Substituted Benzimidazoles |
| title_short | Synthesis and Analgesic Activity of Novel Derivatives of 1,2-Substituted Benzimidazoles |
| title_sort | synthesis and analgesic activity of novel derivatives of 1 2 substituted benzimidazoles |
| url | http://dx.doi.org/10.1155/2013/694295 |
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